Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor
Wilson, Jonathan E., Patel, Gaurav, Patel, Chirag, Brucelle, Francois, Huhn, Annissa, Gardberg, Anna S., Poy, Florence, Cantone, Nico, Bommi-Reddy, Archana, Sims, Robert J., Cummings, Richard T., Levell, Julian R.
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor
Cho, Young Shin, Levell, Julian R, Liu, Gang, Caferro, Thomas, Sutton, James, Shafer, Cynthia M, Costales, Abran, Manning, James R, Zhao, Qian, Sendzik, Martin, Shultz, Michael, Chenail, Gregg, Dooley, Julia, Villalba, Brian, Farsidjani, Ali, Chen, Jinyun, Kulathila, Raviraj, Xie, Xiaoling, Dodd, Stephanie, Gould, Ty, Liang, Guiqing, Heimbach, Tycho, Slocum, Kelly, Firestone, Brant, Pu, Minying, Pagliarini, Raymond, Growney, Joseph D
Published in ACS medicinal chemistry letters (12.10.2017)
Published in ACS medicinal chemistry letters (12.10.2017)
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Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity
Stuckey, Jacob I., Cantone, Nico R., Côté, Alexandre, Arora, Shilpi, Vivat, Valerie, Ramakrishnan, Ashwin, Mertz, Jennifer A., Khanna, Avinash, Brenneman, Jehrod, Gehling, Victor S., Moine, Ludivine, Sims, Robert J., Audia, James E., Trojer, Patrick, Levell, Julian R., Cummings, Richard T.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time
Khanna, Avinash, Cote, Alexandre, Arora, Shilpi, Moine, Ludivine, Gehling, Victor S., Brenneman, Jehrod, Cantone, Nico, Stuckey, Jacob, Apte, Shruti, Ramakrishnan, Ashwin, Bruderek, Kamil, Bradley, William D., Audia, James E., Cummings, Richard T., Sims, Robert J., Trojer, Patrick, Levell, Julian R.
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors
Gehling, Victor S., Mcgrath, John P., Duplessis, Martin, Khanna, Avinash, Brucelle, Francois, Vaswani, Rishi G., Cote, Alexandre, Stuckey, Jacob, Watson, Venita, Cummings, Richard T., Balasubramanian, Srividya, Iyer, Priya, Sawant, Priyanka, Good, Andrew C., Albrecht, Brian K., Harmange, Jean-Christophe, Audia, James E., Bellon, Steven F., Trojer, Patrick, Levell, Julian R.
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Optimization of 3‑Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1
Levell, Julian R., Caferro, Thomas, Chenail, Gregg, Dix, Ina, Dooley, Julia, Firestone, Brant, Fortin, Pascal D., Giraldes, John, Gould, Ty, Growney, Joseph D., Jones, Michael D., Kulathila, Raviraj, Lin, Fallon, Liu, Gang, Mueller, Arne, van der Plas, Simon, Slocum, Kelly, Smith, Troy, Terranova, Remi, Touré, B. Barry, Tyagi, Viraj, Wagner, Trixie, Xie, Xiaoling, Xu, Ming, Yang, Fan S., Zhou, Liping X., Pagliarini, Raymond, Cho, Young Shin
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Optimization of 3‑Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors
Zhao, Qian, Manning, James R., Sutton, James, Costales, Abran, Sendzik, Martin, Shafer, Cynthia M., Levell, Julian R., Liu, Gang, Caferro, Thomas, Cho, Young Shin, Palermo, Mark, Chenail, Gregg, Dooley, Julia, Villalba, Brian, Farsidjani, Ali, Chen, Jinyun, Dodd, Stephanie, Gould, Ty, Liang, Guiqing, Slocum, Kelly, Pu, Minying, Firestone, Brant, Growney, Joseph, Heimbach, Tycho, Pagliarini, Raymond
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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TREX1의 조절제로서의 치환된 벤즈아마이드
LEVELL JULIAN R, WILSON JONATHAN E, COFFIN AARON, MEDIKONDA ARAVIND PRASAD, ZABLOCKI MARY MARGARET, TAVERAS KENNEDY
Year of Publication 03.02.2023
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Year of Publication 03.02.2023
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TREX1의 조절제
LEVELL JULIAN R, WILSON JONATHAN E, MCELROY WILLIAM T, KHANNA AVINASH, GUERIN DAVID J, COFFIN AARON, ROCNIK JENNIFER L, ZABLOCKI MARY MARGARET
Year of Publication 05.03.2024
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Year of Publication 05.03.2024
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TREX1의 조절인자
LEVELL JULIAN R, WILSON JONATHAN E, GEHLING VICTOR S, KHANNA AVINASH, GARDBERG ANNA, TAVERAS KENNEDY
Year of Publication 19.08.2021
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Year of Publication 19.08.2021
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Benzotriazole-Mediated Conversions of para-H-Substituted Pyrylium, Benzo[b]pyrylium, and Xanthylium Salts into para-Position Functionalized Derivatives (An Indirect Electrophilic Substitution of Electron-Deficient Heteroaromatics)
Katritzky, Alan R, Czerney, Peter, Levell, Julian R
Published in Journal of organic chemistry (14.11.1997)
Published in Journal of organic chemistry (14.11.1997)
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Molecular Engineering of Benzo[b]pyrylium Salts by Indirect Electrophilic Substitution
Katritzky, Alan R., Czerney, Peter, Levell, Julian R., Du, Weihong
Published in European journal of organic chemistry (01.11.1998)
Published in European journal of organic chemistry (01.11.1998)
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