Discovery of potent allosteric antibodies inhibiting EGFR
Fournier, Léxane, Pekar, Lukas, Leuthner, Birgitta, Kolmar, Harald, Toleikis, Lars, Becker, Stefan
Published in mAbs (31.12.2024)
Published in mAbs (31.12.2024)
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Journal Article
A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors
Menon, Malini, Elliott, Richard, Bowers, Leandra, Balan, Nicolae, Rafiq, Rumana, Costa-Cabral, Sara, Munkonge, Felix, Trinidade, Ines, Porter, Roderick, Campbell, Andrew D., Johnson, Emma R., Esdar, Christina, Buchstaller, Hans-Peter, Leuthner, Birgitta, Rohdich, Felix, Schneider, Richard, Sansom, Owen, Wienke, Dirk, Ashworth, Alan, Lord, Christopher J.
Published in Scientific reports (17.01.2019)
Published in Scientific reports (17.01.2019)
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Journal Article
Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen
Mallinger, Aurélie, Crumpler, Simon, Pichowicz, Mark, Waalboer, Dennis, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Wood, Bozena, Smith, Elizabeth, Thai, Ching, Henley, Alan T, Georgi, Katrin, Court, William, Hobbs, Steve, Box, Gary, Ortiz-Ruiz, Maria-Jesus, Valenti, Melanie, De Haven Brandon, Alexis, TePoele, Robert, Leuthner, Birgitta, Workman, Paul, Aherne, Wynne, Poeschke, Oliver, Dale, Trevor, Wienke, Dirk, Esdar, Christina, Rohdich, Felix, Raynaud, Florence, Clarke, Paul A, Eccles, Suzanne A, Stieber, Frank, Schiemann, Kai, Blagg, Julian
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Structure-based optimization of non-peptidic Cathepsin D inhibitors
Grädler, Ulrich, Czodrowski, Paul, Tsaklakidis, Christos, Klein, Markus, Werkmann, Daniela, Lindemann, Sven, Maskos, Klaus, Leuthner, Birgitta
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
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Journal Article
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects
Schindler, Christina E. M, Baumann, Hannah, Blum, Andreas, Böse, Dietrich, Buchstaller, Hans-Peter, Burgdorf, Lars, Cappel, Daniel, Chekler, Eugene, Czodrowski, Paul, Dorsch, Dieter, Eguida, Merveille K. I, Follows, Bruce, Fuchß, Thomas, Grädler, Ulrich, Gunera, Jakub, Johnson, Theresa, Jorand Lebrun, Catherine, Karra, Srinivasa, Klein, Markus, Knehans, Tim, Koetzner, Lisa, Krier, Mireille, Leiendecker, Matthias, Leuthner, Birgitta, Li, Liwei, Mochalkin, Igor, Musil, Djordje, Neagu, Constantin, Rippmann, Friedrich, Schiemann, Kai, Schulz, Robert, Steinbrecher, Thomas, Tanzer, Eva-Maria, Unzue Lopez, Andrea, Viacava Follis, Ariele, Wegener, Ansgar, Kuhn, Daniel
Published in Journal of chemical information and modeling (23.11.2020)
Published in Journal of chemical information and modeling (23.11.2020)
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Journal Article
Differences in Sustained Cellular Effects of MET inhibitors Are Driven by Prolonged Target Engagement and Lysosomal Retention
Berges, Nina, Klug, Jan Henrik, Eicher, Anna, Loehr, Jennifer, Schwarz, Daniel, Bomke, Joerg, Leuthner, Birgitta, Perrin, Dominique, Schadt, Oliver
Published in Molecular pharmacology (01.02.2023)
Published in Molecular pharmacology (01.02.2023)
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Journal Article
Cryo-EM Structures of CRAF2/14-3-32 and CRAF2/14-3-32/MEK12 Complexes
Dedden, Dirk, Nitsche, Julius, Schneider, Elisabeth V., Thomsen, Maren, Schwarz, Daniel, Leuthner, Birgitta, Grädler, Ulrich
Published in Journal of molecular biology (15.03.2024)
Published in Journal of molecular biology (15.03.2024)
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Journal Article
Corrigendum to “Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors” [Bioorg. Med. Chem. Lett. 30 (2020) 127551]
Grädler, Ulrich, Busch, Michael, Leuthner, Birgitta, Raba, Michael, Burgdorf, Lars, Lehmann, Martin, Linde, Nina, Esdar, Christina
Published in Bioorganic & medicinal chemistry letters (01.10.2021)
Published in Bioorganic & medicinal chemistry letters (01.10.2021)
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Journal Article
Discovery and Optimization of 2‑Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity
Buchstaller, Hans-Peter, Anlauf, Uwe, Dorsch, Dieter, Kuhn, Daniel, Lehmann, Martin, Leuthner, Birgitta, Musil, Djordje, Radtki, Daniela, Ritzert, Claudio, Rohdich, Felix, Schneider, Richard, Esdar, Christina
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Journal Article
Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors
Grädler, Ulrich, Busch, Michael, Leuthner, Birgitta, Raba, Michael, Burgdorf, Lars, Lehmann, Martin, Linde, Nina, Esdar, Christina
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
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Journal Article
Abstract 1019: The MET inhibitor tepotinib shows sustained effects on MET phosphorylation and viability in cellular washout experiments
Berges, Nina, Klug, Jan Henrik, Eicher, Anna, Loehr, Jennifer, Schwarz, Daniel, Bomke, Joerg, Leuthner, Birgitta, Perrin, Dominique, Schadt, Oliver
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies
Grädler, Ulrich, Schwarz, Daniel, Blaesse, Michael, Leuthner, Birgitta, Johnson, Theresa L., Bernard, Frederic, Jiang, Xuliang, Marx, Andreas, Gilardone, Marine, Lemoine, Hugues, Roche, Didier, Jorand-Lebrun, Catherine
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
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Journal Article
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase‑2 (MetAP-2) Inhibitors
Heinrich, Timo, Seenisamy, Jeyaprakashnarayanan, Blume, Beatrix, Bomke, Jörg, Calderini, Michel, Eckert, Uwe, Friese-Hamim, Manja, Kohl, Rainer, Lehmann, Martin, Leuthner, Birgitta, Musil, Djordje, Rohdich, Felix, Zenke, Frank T
Published in Journal of medicinal chemistry (23.05.2019)
Published in Journal of medicinal chemistry (23.05.2019)
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Journal Article
Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design
Krieger, Johannes, Sorrell, Fiona J., Wegener, Ansgar A., Leuthner, Birgitta, Machrouhi‐Porcher, Fouzia, Hecht, Martin, Leibrock, Eva M., Müller, Juliane E., Eisert, Jonathan, Hartung, Ingo V., Schlesiger, Sarah
Published in ChemMedChem (17.04.2023)
Published in ChemMedChem (17.04.2023)
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Journal Article
Identification of Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer
Heinrich, Timo, Seenisamy, Jeyaprakashnarayanan, Becker, Frank, Blume, Beatrix, Bomke, Jörg, Dietz, Melanie, Eckert, Uwe, Friese-Hamim, Manja, Gunera, Jakub, Hansen, Kerrin, Leuthner, Birgitta, Musil, Djordje, Pfalzgraf, Jens, Rohdich, Felix, Siegl, Christian, Spuck, Dieter, Wegener, Ansgar, Zenke, Frank T
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Journal Article
Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models
Friese-Hamim, Manja, Ortiz Ruiz, Maria J, Bogatyrova, Olga, Keil, Marina, Rohdich, Felix, Blume, Beatrix, Leuthner, Birgitta, Czauderna, Frank, Hahn, Diane, Jabs, Julia, Jaehrling, Frank, Heinrich, Timo, Kellner, Roland, Chan, Katherine, Tong, Amy H Y, Wienke, Dirk, Moffat, Jason, Blaukat, Andree, Zenke, Frank T
Published in Molecular cancer therapeutics (01.02.2024)
Published in Molecular cancer therapeutics (01.02.2024)
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Journal Article
Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors
Buchstaller, Hans-Peter, Sala-Hojman, Ada, Leiendecker, Matthias, Albers, Joachim, Anlauf, Uwe, Berges, Nina, Dong, Liming, Fuchß, Thomas, Germann, Martina, Knehans, Tim, Krier, Mireille, Lecomte, Marc, Müller, Daniel, Müller, Sandra R., Leuthner, Birgitta, Lindemann, Ralph, Musil, Djordje, Nowak, Mateusz, Reither, Vivian, Rettig, Corinna, Schindler, Christina E. M., Pakulska, Urszula, Spuck, Dieter, Wegener, Ansgar, Zarębski, Adrian
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
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Journal Article
Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models
Buchstaller, Hans-Peter, Anlauf, Uwe, Dorsch, Dieter, Kögler, Sarah, Kuhn, Daniel, Lehmann, Martin, Leuthner, Birgitta, Lodholz, Sara, Musil, Djordje, Radtki, Daniela, Rettig, Corinna, Ritzert, Claudio, Rohdich, Felix, Schneider, Richard, Wegener, Ansgar, Weigt, Stefan, Wilkinson, Kai, Esdar, Christina
Published in Journal of medicinal chemistry (22.07.2021)
Published in Journal of medicinal chemistry (22.07.2021)
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