International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
Panula, Pertti, Chazot, Paul L, Cowart, Marlon, Gutzmer, Ralf, Leurs, Rob, Liu, Wai L S, Stark, Holger, Thurmond, Robin L, Haas, Helmut L
Published in Pharmacological reviews (01.07.2015)
Published in Pharmacological reviews (01.07.2015)
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Journal Article
The clinical pharmacology of non-sedating antihistamines
Yanai, Kazuhiko, Yoshikawa, Takeo, Yanai, Ai, Nakamura, Tadaho, Iida, Tomomitsu, Leurs, Rob, Tashiro, Manabu
Published in Pharmacology & therapeutics (Oxford) (01.10.2017)
Published in Pharmacology & therapeutics (Oxford) (01.10.2017)
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Journal Article
Structural Optimization of BIPPO Analogs as Potent Antimalarials
Zheng, Yang, Matheeussen, An, Maes, Louis, Caljon, Guy, Sterk, Geert Jan, Leurs, Rob
Published in Molecules (Basel, Switzerland) (23.06.2023)
Published in Molecules (Basel, Switzerland) (23.06.2023)
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Journal Article
KLIFS: a structural kinase-ligand interaction database
Kooistra, Albert J, Kanev, Georgi K, van Linden, Oscar P J, Leurs, Rob, de Esch, Iwan J P, de Graaf, Chris
Published in Nucleic acids research (04.01.2016)
Published in Nucleic acids research (04.01.2016)
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Journal Article
Kinetics for Drug Discovery: an industry-driven effort to target drug residence time
Schuetz, Doris A., de Witte, Wilhelmus Egbertus Arnout, Wong, Yin Cheong, Knasmueller, Bernhard, Richter, Lars, Kokh, Daria B., Sadiq, S. Kashif, Bosma, Reggie, Nederpelt, Indira, Heitman, Laura H., Segala, Elena, Amaral, Marta, Guo, Dong, Andres, Dorothee, Georgi, Victoria, Stoddart, Leigh A., Hill, Steve, Cooke, Robert M., De Graaf, Chris, Leurs, Rob, Frech, Matthias, Wade, Rebecca C., de Lange, Elizabeth Cunera Maria, IJzerman, Adriaan P., Müller-Fahrnow, Anke, Ecker, Gerhard F.
Published in Drug discovery today (01.06.2017)
Published in Drug discovery today (01.06.2017)
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Journal Article
Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor
Xia, Ruixue, Shi, Shuang, Xu, Zhenmei, Vischer, Henry F., Windhorst, Albert D., Qian, Yu, Duan, Yaning, Liang, Jiale, Chen, Kai, Zhang, Anqi, Guo, Changyou, Leurs, Rob, He, Yuanzheng
Published in Nature communications (20.03.2024)
Published in Nature communications (20.03.2024)
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Journal Article
BRET-Based Biosensors to Measure Agonist Efficacies in Histamine H1 Receptor-Mediated G Protein Activation, Signaling and Interactions with GRKs and β-Arrestins
Verweij, Eléonore W. E., Bosma, Reggie, Gao, Meichun, van den Bor, Jelle, Al Araaj, Betty, de Munnik, Sabrina M., Ma, Xiaoyuan, Leurs, Rob, Vischer, Henry F.
Published in International journal of molecular sciences (16.03.2022)
Published in International journal of molecular sciences (16.03.2022)
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Journal Article
CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells
Jähnichen, Sven, Blanchetot, Christophe, Maussang, David, Gonzalez-Pajuelo, Maria, Chow, Ken Y., Bosch, Leontien, De Vrieze, Sindi, Serruys, Benedikte, Ulrichts, Hans, Vandevelde, Wesly, Saunders, Michael, De Haard, Hans J., Schols, Dominique, Leurs, Rob, Vanlandschoot, Peter, Verrips, Theo, Smit, Martine J., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2010)
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Journal Article
Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells
Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Published in Scientific reports (25.01.2018)
Published in Scientific reports (25.01.2018)
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Journal Article
The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth
Heukers, Raimond, Fan, Tian Shu, de Wit, Raymond H., van Senten, Jeffrey R., De Groof, Timo W. M., Bebelman, Maarten P., Lagerweij, Tonny, Vieira, Joao, de Munnik, Sabrina M., Smits-de Vries, Laura, van Offenbeek, Jody, Rahbar, Afsar, van Hoorick, Diane, Söderberg-Naucler, Cecilia, Würdinger, Thomas, Leurs, Rob, Siderius, Marco, Vischer, Henry F., Smit, Martine J.
Published in Oncogene (01.07.2018)
Published in Oncogene (01.07.2018)
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Journal Article
Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E4106.30×30K Variant in the Histamine H1 Receptor
Ma, Xiaoyuan, Segura, Marta Arimont, Zarzycka, Barbara, Vischer, Henry F., Leurs, Rob
Published in International journal of molecular sciences (02.04.2021)
Published in International journal of molecular sciences (02.04.2021)
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Journal Article
Histamine H3 Receptor Isoforms: Insights from Alternative Splicing to Functional Complexity
Gao, Meichun, Ooms, Jasper F., Leurs, Rob, Vischer, Henry F.
Published in Biomolecules (Basel, Switzerland) (26.06.2024)
Published in Biomolecules (Basel, Switzerland) (26.06.2024)
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Journal Article
Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks
Kanev, Georgi K, Zhang, Yaran, Kooistra, Albert J, Bender, Andreas, Leurs, Rob, Bailey, David, Würdinger, Thomas, de Graaf, Chris, de Esch, Iwan J. P, Westerman, Bart A
Published in PLoS computational biology (05.09.2023)
Published in PLoS computational biology (05.09.2023)
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Journal Article
Histamine downregulates monocyte CCL2 production through the histamine H4 receptor
Dijkstra, Dorothea, MSc, Leurs, Rob, PhD, Chazot, Paul, PhD, Shenton, Fiona C., MSc, Stark, Holger, PhD, Werfel, Thomas, MD, Gutzmer, Ralf, MD
Published in Journal of allergy and clinical immunology (01.08.2007)
Published in Journal of allergy and clinical immunology (01.08.2007)
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Journal Article
The histamine H3 receptor: from gene cloning to H3 receptor drugs
Leurs, Rob, Bakker, Remko A, Timmerman, Henk, de Esch, Iwan J P
Published in Nature reviews. Drug discovery (01.02.2005)
Published in Nature reviews. Drug discovery (01.02.2005)
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