Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
Abdelfattah, Nourhan, Kumar, Parveen, Wang, Caiyi, Leu, Jia-Shiun, Flynn, William F., Gao, Ruli, Baskin, David S., Pichumani, Kumar, Ijare, Omkar B., Wood, Stephanie L., Powell, Suzanne Z., Haviland, David L., Parker Kerrigan, Brittany C., Lang, Frederick F., Prabhu, Sujit S., Huntoon, Kristin M., Jiang, Wen, Kim, Betty Y. S., George, Joshy, Yun, Kyuson
Published in Nature communications (09.02.2022)
Published in Nature communications (09.02.2022)
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Journal Article
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis
Xu, Daqian, Wang, Zheng, Xia, Yan, Shao, Fei, Xia, Weiya, Wei, Yongkun, Li, Xinjian, Qian, Xu, Lee, Jong-Ho, Du, Linyong, Zheng, Yanhua, Lv, Guishuai, Leu, Jia-shiun, Wang, Hongyang, Xing, Dongming, Liang, Tingbo, Hung, Mien-Chie, Lu, Zhimin
Published in Nature (London) (23.04.2020)
Published in Nature (London) (23.04.2020)
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Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression
Alban, Tyler J, Bayik, Defne, Otvos, Balint, Rabljenovic, Anja, Leng, Lin, Jia-Shiun, Leu, Roversi, Gustavo, Lauko, Adam, Momin, Arbaz A, Mohammadi, Alireza M, Peereboom, David M, Ahluwalia, Manmeet S, Matsuda, Kazuko, Yun, Kyuson, Bucala, Richard, Vogelbaum, Michael A, Lathia, Justin D
Published in Frontiers in immunology (18.06.2020)
Published in Frontiers in immunology (18.06.2020)
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Radiation with STAT3 Blockade Triggers Dendritic Cell-T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy
Ott, Martina, Kassab, Cynthia, Marisetty, Anantha, Hashimoto, Yuuri, Wei, Jun, Zamler, Daniel, Leu, Jia-Shiun, Tomaszowski, Karl-Heinz, Sabbagh, Aria, Fang, Dexing, Gupta, Pravesh, Priebe, Waldemar, Zielinski, Rafal J, Burks, Jared K, Long, James P, Kong, Ling-Yuan, Fuller, Gregory N, DeGroot, John, Sulman, Erik P, Heimberger, Amy B
Published in Clinical cancer research (15.09.2020)
Published in Clinical cancer research (15.09.2020)
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SP110b Controls Host Immunity and Susceptibility to Tuberculosis
Leu, Jia-Shiun, Chen, Mei-Ling, Chang, So-Yi, Yu, Sung-Liang, Lin, Chia-Wei, Wang, Hsuan, Chen, Wan-Chen, Chang, Chin-Hao, Wang, Jann-Yuan, Lee, Li-Na, Yu, Chong-Jen, Kramnik, Igor, Yan, Bo-Shiun
Published in American journal of respiratory and critical care medicine (01.02.2017)
Published in American journal of respiratory and critical care medicine (01.02.2017)
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TMIC-73. SEX DIFFERENCES IN INTERFERON-GAMMA RESPONSES IN GLIOMA MICROENVIRONMENT
Leu, Jia-Shiun, Tran, Han Nhat, Ismail, Taha S, Yun, Kyuson
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
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IMMU-66. PHYSIOLOGICALLY RELEVANT MURINE GLIOMA MODELS THAT REPRESENT GBM HETEROGENEITY AND ENABLE THE NEXT GENERATION OF DISCOVERY AND THERAPY EFFICACY STUDIES
Maldonado, Jose, Wang, Caiyi, Leu, Jia-Shiun, Tran, Han Nhat, Abdelfattah, Nourhan, Yun, Kyuson
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
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EXTH-78. A NOVEL BISPECIFIC S100A4/TFR ANTIBODY TO REPROGRAM THE GLIOMA TUMOR MICROENVIRONMENT AND TARGET GLIOMA STEM CELLS
Wong, Thomas, Leu, Jia-Shiun, Fan, Xuejun, Kang, Reece, Abdelfattah, Nourhan, Leonard, Fransisca, Zhang, Ningyan, Yun, Kyuson
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
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Methylation of RNA N 6 -methyladenosine in modulation of cytokine responses and tumorigenesis
Chang, Guoqiang, Leu, Jia-Shiun, Ma, Li, Xie, Keping, Huang, Suyun
Published in Cytokine (Philadelphia, Pa.) (01.06.2019)
Published in Cytokine (Philadelphia, Pa.) (01.06.2019)
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TMIC-60. CROSS-SPECIES ANALYSIS OF HUMAN AND NEW MOUSE MODELS OF GBM SUBTYPES IDENTIFIES VISTA AS A PROMISING IMMUNOTHERAPY TARGET
Madonado, Jose, Wang, Caiyi, Leu, Jia-Shiun, Wong, Thomas, Abdelfattah, Nourhan, Gallup, Thomas, Paik, Jihye, Squatrito, Massimo, Yun, Kyuson
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
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Journal Article
Methylation of RNA N6-methyladenosine in modulation of cytokine responses and tumorigenesis
Chang, Guoqiang, Leu, Jia-Shiun, Ma, Li, Xie, Keping, Huang, Suyun
Published in Cytokine (Philadelphia, Pa.) (01.06.2019)
Published in Cytokine (Philadelphia, Pa.) (01.06.2019)
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Abstract 2711: A novel bispecific antibody to reprogram the immune suppressive GBM TME
Wong, Thomas, Leu, Jia-Shiun, Fan, Xuejun, Kang, Reece, Abdelfattah, Nourhan, Leonard, Fransisca, Zhang, Ningyan, Yun, Kyuson
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 2948: A humanized therapeutic antibody against S100A4 as a novel immune modulator and an inhibitor of cancer metastasis
Leu, Jia-Shiun, Deng, Hui, Tran, Han Nhat, Salazar, Jose Maria, Maldonado, Jose A., Cristobal, Carlo D., Wei, Xiong, Lee, Hyun-Kyoung, An, Zhiqiang, Zhang, Ningyan, Yun, Kyuson
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
OTME-10. Integrated analysis of human gliomas at the single cell level identifies S100A4 as a novel immunotherapy target
Abdelfattah, Nourhan, Kumar, Parveen, Leu, Jia-Shiun, Flynn, William, Baskin, David, Ptichumani, Kumar, Ijare, Omkar, George, Joshy, Yun, Kyuson
Published in Neuro-oncology advances (05.07.2021)
Published in Neuro-oncology advances (05.07.2021)
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Abstract 1331: Elucidating cell-to-cell communication and immunotherapy responses in deeply characterized mouse models of human glioma subtypes
Wang, Caiyi, Maldonado, Jose, Gallup, Thomas D., Abdelfattah, Nourhan, Leu, Jia-Shiun, Joshy, Nithin, George, joshy, Paik, Jihye, Squatrito, Massimo, Yun, Kyuson
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 5871: Pan-cancer myeloid cell analysis at the single cell level reveals the influence of distinct organ sites in myeloid cell phenotypes and support targeting S100A4 to reverse immune suppression
Abdelfattah, Nourhan, Kumar, Parveen, Wang, Caiyi, Leu, Jia-Shiun, Baskin, David, Flynn, William, Gao, Ruli, Pichumani, Kumar, Ijare, Omkar, Wood, Stephanie, Powell, Suzanne, Haviland, David, Kerrigan, Brittany Parker, Lang, Frederick, Prabhu, Sujit, Huntoon, Kristin, Jiang, Wen, Kim, Betty, George, Joshy, Yun, Kyuson
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 2540: A multi-dimensional analysis of human gliomas at the single cell level identifies immune suppressive macrophage molecular signatures and a novel immunotherapy target for GBM
Abdelfattah, Nourhan, Kumar, Parveen, Wang, Caiyi, Leu, Jia-Shiun, Flynn, William W., Gao, Ruli, Baskin, David S., Pichumani, Kumar, Ijare, Omkar B., Wood, Stephanie, Powell, Suzanne, Haviland, David, Lang, Frederick F., Prabhu, Sujit, Huntoon, Kristin, Kerrigan, Brittany C. Parker, Jiang, Wen Jiang, Kim, Betty Y., George, Joshy, Yun, Kyuson
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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MLTI-01. IMMUNOLOGICAL REPROGRAMMING IN THE CNS TUMOR MICROENVIRONMENT AND THERAPEUTIC EFFICACY OF RADIOTHERAPY WITH STAT3 BLOCKADE
Ott, Martina, Hashimoto, Yuuri, Marisetty, Anantha, Wei, Jun, Zamler, Daniel, Leu, Jia-Shiun, Kong, Ling-Yuan, Zhou, Shouhao, Fuller, Gregory, de Groot, John, Priebe, Waldemar, Sulman, Erik, Heimberger, Amy
Published in Neuro-oncology advances (12.08.2019)
Published in Neuro-oncology advances (12.08.2019)
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Journal Article
Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce immune suppression
Tyler, Alban, Bayik, Defne, Otvos, Balint, Rabljenovic, Anja, Leng, Lin, Leu Jia-Shiun, Roversi, Gustavo, Lauko, Adam, Momin, Arbaz, Mohammadi, Alireza M, Peereboom, David M, Ahluwalia, Manmeet S, Matsuda, Kazuko, Yun, Kyuson, Bucala, Richard, Vogelbaum, Michael A, Lathia, Justin
Published in bioRxiv (20.12.2019)
Published in bioRxiv (20.12.2019)
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