Discovery of the Selective Androgen Receptor Modulator MK-0773 Using a Rational Development Strategy Based on Differential Transcriptional Requirements for Androgenic Anabolism Versus Reproductive Physiology
Schmidt, Azriel, Kimmel, Donald B., Bai, Chang, Scafonas, Angela, Rutledge, SuJane, Vogel, Robert L., McElwee-Witmer, Sheila, Chen, Fang, Nantermet, Pascale V., Kasparcova, Viera, Leu, Chih-tai, Zhang, Hai-Zhuan, Duggan, Mark E., Gentile, Michael A., Hodor, Paul, Pennypacker, Brenda, Masarachia, Patricia, Opas, Evan E., Adamski, Sharon A., Cusick, Tara E., Wang, Jiabing, Mitchell, Helen J., Kim, Yuntae, Prueksaritanont, Thomayant, Perkins, James J., Meissner, Robert S., Hartman, George D., Freedman, Leonard P., Harada, Shun-ichi, Ray, William J.
Published in The Journal of biological chemistry (28.05.2010)
Published in The Journal of biological chemistry (28.05.2010)
Get full text
Journal Article
A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling
Kitagawa, Hirochika, Ray, William J., Glantschnig, Helmut, Nantermet, Pascale V., Yu, Yuanjiang, Leu, Chih-Tai, Harada, Shun-ichi, Kato, Shigeaki, Freedman, Leonard P.
Published in Molecular and Cellular Biology (01.11.2007)
Published in Molecular and Cellular Biology (01.11.2007)
Get full text
Journal Article
Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
Navia, M A, Fitzgerald, P M, McKeever, B M, Leu, C T, Heimbach, J C, Herber, W K, Sigal, I S, Darke, P L, Springer, J P
Published in Nature (London) (16.02.1989)
Published in Nature (London) (16.02.1989)
Get more information
Journal Article
HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins
Darke, Paul L., Nutt, Ruth F., Brady, Stephen F., Garsky, Victor M., Ciccarone, Terrence M., Leu, Chih-Tai, Lumma, Patricia K., Freidinger, Roger M., Veber, Daniel F., Sigal, Irving S.
Published in Biochemical and biophysical research communications (14.10.1988)
Published in Biochemical and biophysical research communications (14.10.1988)
Get full text
Journal Article
Nonpeptide αvβ3 Antagonists. 8. In Vitro and in Vivo Evaluation of a Potent αvβ3 Antagonist for the Prevention and Treatment of Osteoporosis
Hutchinson, John H, Halczenko, Wasyl, Brashear, Karen M, Breslin, Michael J, Coleman, Paul J, Duong, Le T, Fernandez-Metzler, Carmen, Gentile, Michael A, Fisher, John E, Hartman, George D, Huff, Joel R, Kimmel, Donald B, Leu, Chih-Tai, Meissner, Robert S, Merkle, Kara, Nagy, Rose, Pennypacker, Brenda, Perkins, James J, Prueksaritanont, Thomayant, Rodan, Gideon A, Varga, Sandor L, Wesolowski, Greg A, Zartman, Amy E, Rodan, Sevgi B, Duggan, Mark E
Published in Journal of medicinal chemistry (23.10.2003)
Published in Journal of medicinal chemistry (23.10.2003)
Get full text
Journal Article
Design, Synthesis, and Biological Evaluation of 16-Substituted 4-Azasteroids as Tissue-Selective Androgen Receptor Modulators (SARMs)
Mitchell, Helen J, Dankulich, William P, Hartman, George D, Prueksaritanont, Thomayant, Schmidt, Azriel, Vogel, Robert L, Bai, Chang, McElwee-Witmer, Sheila, Zhang, Hai Z, Chen, Fang, Leu, Chih-Tai, Kimmel, Donald B, Ray, William J, Nantermet, Pascale, Gentile, Michael A, Duggan, Mark E, Meissner, Robert S
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
Get full text
Journal Article
Binding Model for Nonpeptide Antagonists of αvβ3 Integrin
Feuston, Bradley P, Culberson, J. Chris, Duggan, Mark E, Hartman, George D, Leu, Chih-Tai, Rodan, Sevgi B
Published in Journal of medicinal chemistry (19.12.2002)
Published in Journal of medicinal chemistry (19.12.2002)
Get full text
Journal Article
Nonpeptide αvβ3 antagonists. Part 2: Constrained glycyl amides derived from the RGD tripeptide
MEISSNER, Robert S, PERKINS, James J, RODAN, Gideon A, RODAN, Sevgi B, WHITMAN, David B, WESOLOWSKI, Gregg A, DUGGAN, Mark E, DUONG, Le T, HARTMAN, George D, HOFFMAN, William F, HUFF, Joel R, IHLE, Nathan C, LEU, Chih-Tai, NAGY, Rose M, NAYLOR-OLSEN, Adel
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Get full text
Journal Article
Non-Peptide αvβ3 Antagonists. Part 4: Potent and Orally Bioavailable Chain-Shortened RGD Mimetics
Coleman, Paul J., Askew, Ben C., Hutchinson, John H., Whitman, David B., Perkins, James J., Hartman, George D., Rodan, Gideon A., Leu, Chih-Tai, Prueksaritanont, Thomayant, Fernandez-Metzler, Carmen, Merkle, Kara M., Lynch, Robert, Lynch, Joseph J., Rodan, Sevgi B., Duggan, Mark E.
Published in Bioorganic & medicinal chemistry letters (02.09.2002)
Published in Bioorganic & medicinal chemistry letters (02.09.2002)
Get full text
Journal Article
Non-peptide αvβ3 antagonists. Part 7: 3-Substituted tetrahydro-[1,8]naphthyridine derivatives
JIABING WANG, BRESLIN, Michael J, HARTMAN, George D, COLEMAN, Paul J, DUGGAN, Mark E, HUNT, Cecilia A, HUTCHINSON, John H, LEU, Chih-Tai, RODAN, Sevgi B, RODAN, Gideon A, DUONG, Le T
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Get full text
Journal Article
Nonpeptide αvβ3 antagonists : identification of potent, chain-shortened 7-oxo RGD mimetics
ZARTMAN, Amy E, DUONG, Le T, FEMANDEZ-METZLER, Carmen, HARTMAN, George D, LEU, Chih-Tai, PRUEKSARITANONT, Thomayant, RODAN, Gideon A, RODAN, Sevgi B, DUGGAN, Mark E, MEISSNER, Robert S
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Get full text
Journal Article
Non-peptide αvβ3 antagonists: Identification of potent, chain-shortened RGD mimetics that incorporate a central pyrrolidinone constraint
PERKINS, James J, DUONG, Le T, DUGGAN, Mark E, MEISSNER, Robert S, FERNANDEZ-METZLER, Carmen, HARTMAN, George D, KIMMEL, Donald B, LEU, Chih-Tai, LYNCH, Joseph J, PRUEKSARITANONT, Thomayant, RODAN, Gideon A, RODAN, Sevgi B
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Get full text
Journal Article
Nonpeptide αvβ3 antagonists. Part 10: in vitro and in vivo evaluation of a potent 7-methyl substituted tetrahydro-[1,8]naphthyridine derivative
BRESLIN, Michael J, DUGGAN, Mark E, PRUEKSARITANONT, Thomayant, RODAN, Gideon A, RODAN, Sevgi B, HUTCHINSON, John H, HALCZENKO, Wasyl, HARTMAN, George D, DUONG, Le T, FERNANDEZ-METZLER, Carmen, GENTILE, Michael A, KIMMEL, Donald B, LEU, Chih-Tai, MERKLE, Kara
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Get full text
Journal Article
Nonpeptide α vβ 3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone
Whitman, David B., Askew, Ben C., Duong, Le T., Fernandez-Metzler, Carmen, Halczenko, Wasyl, Hartman, George D., Hutchinson, John H., Leu, Chih-Tai, Prueksaritanont, Thomayant, Rodan, Gideon A., Rodan, Sevgi B., Duggan, Mark E.
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Get full text
Journal Article
Non-peptide αvβ3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-amino acids as aspartic acid replacements
COLEMAN, Paul J, BRASHEAR, Karen M, RODAN, Gideon A, LEU, Chih-Tai, PRUEKSARITANONT, Thomayant, FERNANDEZ-METZLER, Carmen, MA, Bennett, LIBBY, Laura A, MERKLE, Kara M, STUMP, Gary L, WALLACE, Audrey A, LYNCH, Joseph J, HUNT, Cecilia A, LYNCH, Robert, DUGGAN, Mark E, HOFFMAN, William F, HUTCHINSON, John H, BRESLIN, Michael J, MCVEAN, Carol A, ASKEW, Ben C, HARTMAN, George D, RODAN, Sevgi B
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Get full text
Journal Article
Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution
FITZGERALD, P. M. D, MCKEEVER, B. M, VANMIDDLESWORTH, J. F, SPRINGER, J. P, HEIMBACH, J. C, CHIH-TAI LEU, HERBER, W. K, DIXON, R. A. F, DARKE, P. L
Published in The Journal of biological chemistry (25.08.1990)
Published in The Journal of biological chemistry (25.08.1990)
Get full text
Journal Article
Human immunodeficiency virus protease. Bacterial expression and characterization of the purified aspartic protease
Darke, P L, Leu, C T, Davis, L J, Heimbach, J C, Diehl, R E, Hill, W S, Dixon, R A, Sigal, I S
Published in The Journal of biological chemistry (05.02.1989)
Get full text
Published in The Journal of biological chemistry (05.02.1989)
Journal Article