MAP3K11/GDF15 axis is a critical driver of cancer cachexia
Lerner, Lorena, Tao, Julie, Liu, Qing, Nicoletti, Richard, Feng, Bin, Krieger, Brian, Mazsa, Elizabeth, Siddiquee, Zakir, Wang, Ruoji, Huang, Lucia, Shen, Luhua, Lin, Jie, Vigano, Antonio, Chiu, M. Isabel, Weng, Zhigang, Winston, William, Weiler, Solly, Gyuris, Jeno
Published in Journal of cachexia, sarcopenia and muscle (01.09.2016)
Published in Journal of cachexia, sarcopenia and muscle (01.09.2016)
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Journal Article
Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer
Kennedy, Edward M., Denslow, Agnieszka, Hewett, Jacqueline, Kong, Lingxin, De Almeida, Ana, Bryant, Jeffrey D., Lee, Jennifer S., Jacques, Judy, Feau, Sonia, Hayes, Melissa, McMichael, Elizabeth L., Wambua, Daniel, Farkaly, Terry, Rahmeh, Amal A, Herschelman, Lauren, Douglas, Danielle, Spinale, Jacob, Adhikari, Sanmit, Deterling, Jessica, Scott, Matt, Haines, Brian B., Finer, Mitchell H., Ashburn, Ted T, Quéva, Christophe, Lerner, Lorena
Published in Nature communications (07.10.2022)
Published in Nature communications (07.10.2022)
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Journal Article
Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer
Buck, Elizabeth, Gokhale, Prafulla C, Koujak, Susan, Brown, Eric, Eyzaguirre, Alexandra, Tao, Nianjun, Rosenfeld-Franklin, Maryland, Lerner, Lorena, Chiu, M Isabel, Wild, Robert, Epstein, David, Pachter, Jonathan A, Miglarese, Mark R
Published in Molecular cancer therapeutics (01.10.2010)
Published in Molecular cancer therapeutics (01.10.2010)
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Journal Article
GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling
AILIN BAI, MEETZE, Kristan, JINWEI JIANG, LERNER, Lorena, GYURIS, Jeno, ZHIGANG WENG, VO, Nhi Y, KOLLIPARA, Sriram, MAZSA, Elizabeth K, WINSTON, William M, WEILER, Solly, POLING, Laura L, TING CHEN, ISMAIL, Nesreen S
Published in Cancer research (Chicago, Ill.) (01.10.2010)
Published in Cancer research (Chicago, Ill.) (01.10.2010)
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Journal Article
Seneca Valley virus replicons are packaged in trans and have the capacity to overcome the limitations of viral transgene expression
Bryant, Jeffrey D., Lee, Jennifer S., De Almeida, Ana, Jacques, Judy, Chang, Ching-Hung, Fassler, William, Quéva, Christophe, Lerner, Lorena, Kennedy, Edward M.
Published in Molecular therapy. Oncolytics (16.03.2023)
Published in Molecular therapy. Oncolytics (16.03.2023)
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Journal Article
P1488: COMBINING ALK2 INHIBITION WITH A MODIFIED ACTIVIN RECEPTOR IIA LIGAND TRAP PROVIDED ADDITIVE BENEFITS IN RESOLVING ANEMIA IN A MOUSE MODEL OF ANEMIA OF INFLAMMATION
Wang, Chia‐Yu, Melgar‐Bermudez, Emiliano, Welch, Diana, Tseng, Claire, Fisher, Ffolliott, Cadena, Samuel, Lerner, Lorena, Seehra, Jasbir, Lachey, Jenn
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Journal Article
Design of an Interferon-Resistant Oncolytic HSV-1 Incorporating Redundant Safety Modalities for Improved Tolerability
Kennedy, Edward M., Farkaly, Terry, Grzesik, Peter, Lee, Jennifer, Denslow, Agnieszka, Hewett, Jacqueline, Bryant, Jeffrey, Behara, Prajna, Goshert, Caitlin, Wambua, Daniel, De Almeida, Ana, Jacques, Judith, Deavall, Damian, Rottman, James B., Glorioso, Joseph C., Finer, Mitchell H., Haines, Brian B., Quéva, Christophe, Lerner, Lorena
Published in Molecular therapy. Oncolytics (25.09.2020)
Published in Molecular therapy. Oncolytics (25.09.2020)
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Journal Article
Independent and Cooperative Activation of Chromosomal c-fos Promoter by STAT3
Yang, Edward, Lerner, Lorena, Besser, Daniel, Darnell, James E.
Published in The Journal of biological chemistry (02.05.2003)
Published in The Journal of biological chemistry (02.05.2003)
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Journal Article
Rker-216 Reversed Microcytic Anemia in a Mouse Model of Iron Refractory Iron Deficiency Anemia
Wang, Chia-Yu, Melgar-Bermudez, Emiliano, Welch, Diana, Cadena, Samuel, Lerner, Lorena, Seehra, Jasbir, Lachey, Jenn
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
DEVELOPMENT OF KER-012, AN INVESTIGATIONAL MODIFIED ACTRIIB LIGAND TRAP, FOR THE TREATMENT OF CHRONIC HEART FAILURE: TRANSLATION OF PRECLINICAL FINDINGS TO HUMAN BIOMARKERS OF CARDIAC DYSFUNCTION AND HEART FAILURE
Natarajan, Harveen, Lerner, Lorena, Babbs, Keith, Fisher, ffolliott Martin, Materna, Christopher, Bedard, Sylvain, Steiner, M. Kathryn, Grayson, Dena, Cooper, Simon
Published in Journal of the American College of Cardiology (02.04.2024)
Published in Journal of the American College of Cardiology (02.04.2024)
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Journal Article
Rker-050, a Modified Activin Receptor Type Iia Ligand Trap, Promoted Erythropoiesis in a Murine Model of Myelofibrosis
Moses, Blake, Dills, Mike, Wheeler, Ashlyn, Todorova, Radina, Macaluso, Savanna, Damen, Tyler, Cadena, Samuel, Lerner, Lorena, Seehra, Jasbir, Lachey, Jenn
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
ALK2 Inhibition and a Modified Activin Receptor Type Iia Ligand Trap Cotherapy Maximized Hematologic Improvements in a Mouse Model of Anemia of Inflammation
Wang, Chia-Yu, Melgar-Bermudez, Emiliano, Welch, Diana, Tseng, Claire C, Fisher, Ffolliott, Cadena, Samuel M, Lerner, Lorena, Seehra, Jasbir, Lachey, Jenn
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients
Lerner, Lorena, Hayes, Teresa G., Tao, Nianjun, Krieger, Brian, Feng, Bin, Wu, Zhenhua, Nicoletti, Richard, Chiu, M. Isabel, Gyuris, Jeno, Garcia, Jose M.
Published in Journal of cachexia, sarcopenia and muscle (01.12.2015)
Published in Journal of cachexia, sarcopenia and muscle (01.12.2015)
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Journal Article
ONCR-177, an Oncolytic HSV-1 Designed to Potently Activate Systemic Antitumor Immunity
Haines, Brian B, Denslow, Agnieszka, Grzesik, Peter, Lee, Jennifer S, Farkaly, Terry, Hewett, Jacqueline, Wambua, Daniel, Kong, Lingxin, Behera, Prajna, Jacques, Judith, Goshert, Caitlin, Ball, Michael, Colthart, Allison, Finer, Mitchel H, Hayes, Melissa W, Feau, Sonia, Kennedy, Edward M, Lerner, Lorena, Quéva, Christophe
Published in Cancer immunology research (01.03.2021)
Published in Cancer immunology research (01.03.2021)
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Journal Article
EXTH-60. ONCR-GBM, A NOVEL ARMED ONCOLYTIC HSV-1 VECTOR ENGINEERED FOR EFFICACY AND SAFETY IN GLIOBLASTOMA
Strathdee, Craig, Giovannoni, Federico, Molgora, Martina, Kong, Lingxin, Floyd, Michael, Teng, Jian, Gyulakian, Yulia, Grzesik, Peter, Farkaly, Terry, Denslow, Agnieszka, Feau, Sonia, Jacques, Judith, Kennedy, Edward, Lerner, Lorena, Quéva, Christophe, Colonna, Marco, Quintana, Francisco
Published in Neuro-oncology (Charlottesville, Va.) (14.11.2022)
Published in Neuro-oncology (Charlottesville, Va.) (14.11.2022)
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