Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin‐Targeted Conjugate
Raposo Moreira Dias, André, Pina, Arianna, Dean, Amelia, Lerchen, Hans‐Georg, Caruso, Michele, Gasparri, Fabio, Fraietta, Ivan, Troiani, Sonia, Arosio, Daniela, Belvisi, Laura, Pignataro, Luca, Dal Corso, Alberto, Gennari, Cesare
Published in Chemistry : a European journal (01.02.2019)
Published in Chemistry : a European journal (01.02.2019)
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Journal Article
Antibody–Drug Conjugates with Pyrrole‐Based KSP Inhibitors as the Payload Class
Lerchen, Hans‐Georg, Wittrock, Sven, Stelte‐Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Griebenow, Nils, Rebstock, Anne‐Sophie, Johannes, Sarah, Cancho‐Grande, Yolanda, Mahlert, Christoph, Greven, Simone, Terjung, Carsten
Published in Angewandte Chemie International Edition (12.11.2018)
Published in Angewandte Chemie International Edition (12.11.2018)
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Journal Article
Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation
Lerchen, Hans‐Georg, Stelte‐Ludwig, Beatrix, Berndt, Sandra, Sommer, Anette, Dietz, Lisa, Rebstock, Anne‐Sophie, Johannes, Sarah, Marx, Leo, Jörißen, Hannah, Mahlert, Christoph, Greven, Simone
Published in Chemistry : a European journal (21.06.2019)
Published in Chemistry : a European journal (21.06.2019)
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Journal Article
Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A1 Receptor Agonist for the Chronic Treatment of Heart Diseases
Meibom, Daniel, Albrecht‐Küpper, Barbara, Diedrichs, Nicole, Hübsch, Walter, Kast, Raimund, Krämer, Thomas, Krenz, Ursula, Lerchen, Hans‐Georg, Mittendorf, Joachim, Nell, Peter G., Süssmeier, Frank, Vakalopoulos, Alexandros, Zimmermann, Katja
Published in ChemMedChem (22.05.2017)
Published in ChemMedChem (22.05.2017)
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Journal Article
Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors
Sommer, Anette, Kopitz, Charlotte, Schatz, Christoph A, Nising, Carl F, Mahlert, Christoph, Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Hammer, Stefanie, Greven, Simone, Schuhmacher, Joachim, Braun, Manuela, Zierz, Ruprecht, Wittemer-Rump, Sabine, Harrenga, Axel, Dittmer, Frank, Reetz, Frank, Apeler, Heiner, Jautelat, Rolf, Huynh, Hung, Ziegelbauer, Karl, Kreft, Bertolt
Published in Cancer research (Chicago, Ill.) (01.11.2016)
Published in Cancer research (Chicago, Ill.) (01.11.2016)
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Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment
Rebstock, Anne-Sophie, Wiedmann, Mareike, Stelte-Ludwig, Beatrix, Wong, Harvey, Johnson, Amy J, Izumi, Raquel, Hamdy, Ahmed, Lerchen, Hans-Georg
Published in Frontiers in pharmacology (01.03.2024)
Published in Frontiers in pharmacology (01.03.2024)
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Journal Article
Discovery of VIP236, an αvβ3-Targeted Small-Molecule–Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors
Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Heroult, Melanie, Zubov, Dmitry, Gericke, Kersten Matthias, Wong, Harvey, Frigault, Melanie M, Johnson, Amy J, Izumi, Raquel, Hamdy, Ahmed
Published in Cancers (01.09.2023)
Published in Cancers (01.09.2023)
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Journal Article
Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer
Willuda, Jörg, Linden, Lars, Lerchen, Hans-Georg, Kopitz, Charlotte, Stelte-Ludwig, Beatrix, Pena, Carol, Lange, Claudia, Golfier, Sven, Kneip, Christoph, Carrigan, Patricia E, Mclean, Kirk, Schuhmacher, Joachim, von Ahsen, Oliver, Müller, Jörg, Dittmer, Frank, Beier, Rudolf, El Sheikh, Sherif, Tebbe, Jan, Leder, Gabriele, Apeler, Heiner, Jautelat, Rolf, Ziegelbauer, Karl, Kreft, Bertolt
Published in Molecular cancer therapeutics (01.05.2017)
Published in Molecular cancer therapeutics (01.05.2017)
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Journal Article
Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation
Lerchen, Hans‐Georg, Stelte‐Ludwig, Beatrix, Berndt, Sandra, Sommer, Anette, Dietz, Lisa, Rebstock, Anne‐Sophie, Johannes, Sarah, Marx, Leo, Jörißen, Hannah, Mahlert, Christoph, Greven, Simone
Published in Chemistry : a European journal (21.06.2019)
Published in Chemistry : a European journal (21.06.2019)
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Journal Article
Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties
Sommer, Anette, Berndt, Sandra, Lerchen, Hans-Georg, Forveille, Sabrina, Sauvat, Allan, Mumberg, Dominik, Kroemer, Guido, Kepp, Oliver
Published in Oncoimmunology (2022)
Published in Oncoimmunology (2022)
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Journal Article
Synthetic studies towards bottromycin
Ackermann, Stefanie, Lerchen, Hans-Georg, Häbich, Dieter, Ullrich, Angelika, Kazmaier, Uli
Published in Beilstein journal of organic chemistry (01.10.2012)
Published in Beilstein journal of organic chemistry (01.10.2012)
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Journal Article
A Selective Carborane-Functionalized Gastrin-Releasing Peptide Receptor Agonist as Boron Delivery Agent for Boron Neutron Capture Therapy
Hoppenz, Paul, Els-Heindl, Sylvia, Kellert, Martin, Kuhnert, Robert, Saretz, Stefan, Lerchen, Hans-Georg, Köbberling, Johannes, Riedl, Bernd, Hey-Hawkins, Evamarie, Beck-Sickinger, Annette G
Published in Journal of organic chemistry (07.02.2020)
Published in Journal of organic chemistry (07.02.2020)
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Journal Article
Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads
Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Rebstock, Anne-Sophie, Johannes, Sarah, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah
Published in Bioconjugate chemistry (19.08.2020)
Published in Bioconjugate chemistry (19.08.2020)
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Journal Article
A Small Molecule–Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an αVß3 Binder for the Treatment of Multiple Cancer Types
Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Kopitz, Charlotte, Heroult, Melanie, Zubov, Dmitry, Willuda, Joerg, Schlange, Thomas, Kahnert, Antje, Wong, Harvey, Izumi, Raquel, Hamdy, Ahmed
Published in Cancers (13.01.2022)
Published in Cancers (13.01.2022)
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Journal Article
Lectin-Mediated Drug Targeting: Discrimination of Carbohydrate-Mediated Cellular Uptake between Tumor and Liver Cells with Neoglycoconjugates Carrying Fucose Epitopes Regioselectively Modified in the 3-Position
Lerchen, Hans-Georg, Baumgarten, Joerg, Piel, Norbert, Kolb-Bachofen, Victoria
Published in Angewandte Chemie (International ed.) (16.12.1999)
Published in Angewandte Chemie (International ed.) (16.12.1999)
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Journal Article
Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A 1 Receptor Agonist for the Chronic Treatment of Heart Diseases
Meibom, Daniel, Albrecht-Küpper, Barbara, Diedrichs, Nicole, Hübsch, Walter, Kast, Raimund, Krämer, Thomas, Krenz, Ursula, Lerchen, Hans-Georg, Mittendorf, Joachim, Nell, Peter G, Süssmeier, Frank, Vakalopoulos, Alexandros, Zimmermann, Katja
Published in ChemMedChem (22.05.2017)
Published in ChemMedChem (22.05.2017)
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Journal Article
Innentitelbild: Antikörper‐Wirkstoff‐Konjugate mit Pyrrol‐basierten KSP‐Inhibitoren als Payload‐Klasse (Angew. Chem. 46/2018)
Lerchen, Hans‐Georg, Wittrock, Sven, Stelte‐Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Griebenow, Nils, Rebstock, Anne‐Sophie, Johannes, Sarah, Cancho‐Grande, Yolanda, Mahlert, Christoph, Greven, Simone, Terjung, Carsten
Published in Angewandte Chemie (12.11.2018)
Published in Angewandte Chemie (12.11.2018)
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과증식성 질환의 치료, 예방 또는 관리를 위한 화합물, 약학 조성물 및 방법
WONG HARVEY, REBSTOCK ANNE SOPHIE, LERCHEN HANS GEORG, STELTE LUDWIG BEATRIX, WIEDMANN MAREIKE, KOEBBERLING JOHANNES
Year of Publication 05.07.2024
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Year of Publication 05.07.2024
Patent
과증식성 장애의 치료, 예방, 또는 관리를 위한 화합물, 약제학적 조성물, 및 방법
WONG HARVEY, REBSTOCK ANNE SOPHIE, LERCHEN HANS GEORG, STELTE LUDWIG BEATRIX, WIEDMANN MAREIKE, KOEBBERLING JOHANNES
Year of Publication 20.06.2024
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Year of Publication 20.06.2024
Patent