Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial
Finberg, Robert W, Lanno, Riin, Anderson, David, Fleischhackl, Roman, van Duijnhoven, Wilbert, Kauffman, Robert S, Kosoglou, Teddy, Vingerhoets, Johan, Leopold, Lorant
Published in The Journal of infectious diseases (15.03.2019)
Published in The Journal of infectious diseases (15.03.2019)
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A Phase 2 Study of Pimodivir (JNJ-63623872) in Combination With Oseltamivir in Elderly and Nonelderly Adults Hospitalized With Influenza A Infection: OPAL Study
O’Neil, Brian, Ison, Michael G, Hallouin-Bernard, Marie Charlotte, Nilsson, Anna C, Torres, Antoni, Wilburn, John M, van Duijnhoven, Wilbert, Van Dromme, Ilse, Anderson, David, Deleu, Sofie, Kosoglou, Teddy, Vingerhoets, Johan, Rossenu, Stefaan, Leopold, Lorant
Published in The Journal of infectious diseases (12.08.2022)
Published in The Journal of infectious diseases (12.08.2022)
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Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
Madruga, José Valdez, Dr, Cahn, Pedro, MD, Grinsztejn, Beatriz, MD, Haubrich, Richard, Prof, Lalezari, Jacob, MD, Mills, Anthony, MD, Pialoux, Gilles, Prof, Wilkin, Timothy, MD, Peeters, Monika, MSc, Vingerhoets, Johan, PhD, de Smedt, Goedele, MD, Leopold, Lorant, MD, Trefiglio, Roberta, PharmD, Woodfall, Brian, MD
Published in The Lancet (British edition) (07.07.2007)
Published in The Lancet (British edition) (07.07.2007)
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Efficacy and Safety of Pimodivir Combined with Standard-of-care in Hospitalized and Non-hospitalized High-risk Adolescents and Adults with Influenza A Infection
Leopold, Lorant, Vingerhoets, Johan, Deleu, Sofie, Nalpas, Catherine, Weber, Karin, van Dromme, Ilse, Lowson, David, Michiels, Bart, van Duijnhoven, Wilbert
Published in The Journal of infectious diseases (22.08.2024)
Published in The Journal of infectious diseases (22.08.2024)
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Genotypic and phenotypic characterization of influenza A viral variants in study participants treated with pimodivir in the phase 2b TOPAZ study
Vingerhoets, Johan, Van Dromme, Ilse, van Duijnhoven, Wilbert, Anderson, David, De Meyer, Sandra, Leopold, Lorant
Published in Antiviral therapy (01.06.2023)
Published in Antiviral therapy (01.06.2023)
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Pimodivir treatment in adult volunteers experimentally inoculated with live influenza virus: a Phase IIa, randomized, double-blind, placebo-controlled study
Trevejo, Jose M, Asmal, Mohammed, Vingerhoets, Johan, Polo, Ramon, Robertson, Sarah, Jiang, Ying, Kieffer, Tara L, Leopold, Lorant
Published in Antiviral therapy (01.01.2018)
Published in Antiviral therapy (01.01.2018)
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Single‐ and multiple‐dose pharmacokinetics and safety of pimodivir, a novel, non‐nucleoside polymerase basic protein 2 subunit inhibitor of the influenza A virus polymerase complex, and interaction with oseltamivir: a Phase 1 open‐label study in healthy volunteers
Deleu, Sofie, Kakuda, Thomas N., Spittaels, Kurt, Vercauteren, Jurgen J., Hillewaert, Vera, Lwin, Amy, Leopold, Lorant, Hoetelmans, Richard M. W.
Published in British journal of clinical pharmacology (01.11.2018)
Published in British journal of clinical pharmacology (01.11.2018)
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The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects
Kakuda, Thomas N, Van Solingen-Ristea, Rodica M, Onkelinx, Joelle, Stevens, Tanja, Aharchi, Fatima, De Smedt, Goedele, Peeters, Monika, Leopold, Lorant, Hoetelmans, Richard M W
Published in Journal of clinical pharmacology (01.04.2014)
Published in Journal of clinical pharmacology (01.04.2014)
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Pharmacokinetic interaction between etravirine or rilpivirine and telaprevir in healthy volunteers: A randomized, two-way crossover trial
Kakuda, Thomas N, Leopold, Lorant, Nijs, Steven, Vandevoorde, Ann, Crauwels, Herta M, Bertelsen, Kirk M, Stevens, Marita, Witek, James, van Delft, Yvon, Tomaka, Frank, Hoetelmans, Richard M W
Published in Journal of clinical pharmacology (01.05.2014)
Published in Journal of clinical pharmacology (01.05.2014)
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Bioavailability and bioequivalence of a darunavir 800-mg tablet formulation compared with the 400-mg tablet formulation
Kakuda, Thomas N, Leopold, Lorant, Timmers, Maarten, Van De Casteele, Tom, Hillewaert, Vera, Tomaka, Frank L, Hoetelmans, Richard M W
Published in International journal of clinical pharmacology and therapeutics (01.09.2014)
Published in International journal of clinical pharmacology and therapeutics (01.09.2014)
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Single-dose pharmacokinetics of pediatric and adult formulations of etravirine and swallowability of the 200-mg tablet: results from three Phase 1 studies
Kakuda, Thomas N, Berckmans, Cindy, De Smedt, Goedele, Leemans, Ruud, Leopold, Lorant, Peeters, Monika, Nijs, Steven, Vyncke, Veerle, van Solingen-Ristea, Rodica, Hoetelmans, Richard M W
Published in International journal of clinical pharmacology and therapeutics (01.09.2013)
Published in International journal of clinical pharmacology and therapeutics (01.09.2013)
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Efficacy and safety of TMC125 (etravirine) in treatment-experienced hiv-1-infected patients in DUET-1 : 24-week results from a randomised, double-blind, placebo-controlled trial. Commentary
HIRSCHEL, Bernard, PERNEGER, Thomas, PEETERS, Monika, VINGERHOETS, Johan, DE SMEDT, Goedele, LEOPOLD, Lorant, TREFIGLIO, Roberta, WOODFALL, Brian, LOZZARIN, Adriano, CAMPBELL, Thomas, CLOTET, Bonaventura, JOHNSON, Margaret, VALDEZ MADRUGA, José, KATLAMA, Christine, MOLL, Arend, TOWNER, William, TROTTIER, Benoit, PEETERS, Moniko, VINGERHOETS, Johan, DE SMEDT, Goedele, BAETEN, Benny, BEETS, Greet, SINHA, Rekha, CAHN, Pedro, WOODFALL, Brian, BERGER, Daniel, MCMURCHIE, Marilyn, SUTER, Fredy, BANHEGYI, Denes, RUXRUNGTHAM, Kiat, NOMS, Dorece, LEFEBVRE, Eric, DE BETHUNE, Marie-Pierre, TOMAKA, Frank, GRINSZTEJN, Beatriz, DE PAUW, Martine, VANGENEUGDEN, Tony, SPINOSA-GUZMAN, Sabrina, HAUBRICH, Richard, LALEZARI, Jacob, MILLS, Anthony, PIALOUX, Gilles, WILFEIN, Timothy
Published in The Lancet (British edition) (2007)
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Published in The Lancet (British edition) (2007)
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