Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
Corrales, Leticia, Glickman, Laura Hix, McWhirter, Sarah M., Kanne, David B., Sivick, Kelsey E., Katibah, George E., Woo, Seng-Ryong, Lemmens, Edward, Banda, Tamara, Leong, Justin J., Metchette, Ken, Dubensky, Thomas W., Gajewski, Thomas F.
Published in Cell reports (Cambridge) (19.05.2015)
Published in Cell reports (Cambridge) (19.05.2015)
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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
Fu, Juan, Kanne, David B, Leong, Meredith, Glickman, Laura Hix, McWhirter, Sarah M, Lemmens, Edward, Mechette, Ken, Leong, Justin J, Lauer, Peter, Liu, Weiqun, Sivick, Kelsey E, Zeng, Qi, Soares, Kevin C, Zheng, Lei, Portnoy, Daniel A, Woodward, Joshua J, Pardoll, Drew M, Dubensky, Jr, Thomas W, Kim, Young
Published in Science translational medicine (15.04.2015)
Published in Science translational medicine (15.04.2015)
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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cell reports (Cambridge) (11.12.2018)
Published in Cell reports (Cambridge) (11.12.2018)
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STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection
Van Dis, Erik, Sogi, Kimberly M., Rae, Chris S., Sivick, Kelsey E., Surh, Natalie H., Leong, Meredith L., Kanne, David B., Metchette, Ken, Leong, Justin J., Bruml, Jacob R., Chen, Vivian, Heydari, Kartoosh, Cadieux, Nathalie, Evans, Tom, McWhirter, Sarah M., Dubensky, Thomas W., Portnoy, Daniel A., Stanley, Sarah A.
Published in Cell reports (Cambridge) (01.05.2018)
Published in Cell reports (Cambridge) (01.05.2018)
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Stereochemical Outcomes in Reductive Cyclizations To Form Spirocyclic Heterocycles
Perry, Matthew A, Hill, Richard R, Leong, Justin J, Rychnovsky, Scott D
Published in Organic letters (02.07.2015)
Published in Organic letters (02.07.2015)
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Journal Article
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cell reports (Cambridge) (15.10.2019)
Published in Cell reports (Cambridge) (15.10.2019)
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Abstract 1445: STING activation in the tumor microenvironment with a synthetic human STING-activating cyclic dinucleotide leads to potent anti-tumor immunity
Glickman, Laura Hix, Kanne, David B., Kasibhatla, Shailaja, Li, Jie, Pferdekamper, AnneMarie Culazzo, Gauthier, Kelsey Sivick, Deng, Weiwen, Desbien, Anthony L., Katibah, George E., Leong, Justin J., Sung, Leonard, Metchette, Ken, Ndubaku, Chudi, Zheng, Lianxing, Cho, Charles, Feng, Yan, McKenna, Jeffrey M., Tallarico, John A., Bender, Steven L., Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract SY39-02: Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
Glickman, Laura Hix, Corrales, Leticia, Kanne, David B., Kasibhatla, Shailaja, Li, Jie, Pferdekamper, Anne Marie Culazzo, Gauthier, Kelsey Sivick, Katibah, George E., Leong, Justin J., Sung, Leonard, Metchette, Ken, Deng, Weiwen, Desbien, Anthony L., Ndubaku, Chudi, Zheng, Lianxing, Cho, Charles, Feng, Yan, McKenna, Jeffery M., Tallarico, John A., Bender, Steven L., McWhirter, Sarah M., Gajewski, Thomas F., Dubensky, Thomas W.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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ChemInform Abstract: Stereochemical Outcomes in Reductive Cyclizations to Form Spirocyclic Heterocycles
Perry, Matthew A., Hill, Richard R., Leong, Justin J., Rychnovsky, Scott D.
Published in ChemInform (01.11.2015)
Published in ChemInform (01.11.2015)
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Abstract 631: Intratumoral activation of STING with a synthetic cyclic dinucleotide elicits antitumor CD8 T-cell immunity that effectively combines with checkpoint inhibitors
Desbien, Anthony L., Gauthier, Kelsey Sivick, Corrales, Leticia, Reiner, Gabrielle, Glickman, Laura Hix, Katibah, George, Hudson, Thomas E., Vu, Uyen, Surh, Natalie H., Francica, Brian, Deng, Weiwen, Kanne, David B., Leong, Justin J., Ndubaku, Chudi, Metchette, Ken, McKenna, Jeffery M., Bender, Steven L., Leong, Meredith L., Dubensky, Thomas W., Elsas, Andrea van, McWhirter, Sarah M.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 4272: Potent in situ cancer immunotherapy with synthetic human STING-activating cyclic dinucleotides
Glickman, Laura Hix, Kanne, David B., Gauthier, Kelsey E., Katibah, George E., Leong, Justin J., Metchette, Ken, Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Direct activation of STING in the tumor microenvironment with synthetic cyclic dinucleotide derivatives leads to potent and systemic tumor-specific immunity
Corrales, Leticia, Glickman, Laura Hix, McWhirter, Sarah M, Kanne, David B, Sivick, Kelsey E, Lemmens, Edward, Leong, Justin J, Metchette, Ken, Dubensky, Thomas W, Gajewski, Thomas
Published in Journal for immunotherapy of cancer (06.11.2014)
Published in Journal for immunotherapy of cancer (06.11.2014)
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