Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer
Lenos, Kristiaan J, Miedema, Daniël M, Lodestijn, Sophie C, Nijman, Lisanne E, van den Bosch, Tom, Romero Ros, Xavier, Lourenço, Filipe C, Lecca, Maria C, van der Heijden, Maartje, van Neerven, Sanne M, van Oort, Anita, Leveille, Nicolas, Adam, Ronja S, de Sousa E Melo, Felipe, Otten, Joy, Veerman, Patrick, Hypolite, Guillaume, Koens, Lianne, Lyons, Scott K, Stassi, Giorgio, Winton, Douglas J, Medema, Jan Paul, Morrissey, Edward, Bijlsma, Maarten F, Vermeulen, Louis
Published in Nature cell biology (01.10.2018)
Published in Nature cell biology (01.10.2018)
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Journal Article
The landscape of cell-free mitochondrial DNA in liquid biopsy for cancer detection
van der Pol, Ymke, Moldovan, Norbert, Ramaker, Jip, Bootsma, Sanne, Lenos, Kristiaan J., Vermeulen, Louis, Sandhu, Shahneen, Bahce, Idris, Pegtel, D. Michiel, Wong, Stephen Q., Dawson, Sarah-Jane, Chandrananda, Dineika, Mouliere, Florent
Published in Genome Biology (12.10.2023)
Published in Genome Biology (12.10.2023)
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Journal Article
Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts
van der Heijden, Maartje, Miedema, Daniël M., Waclaw, Bartlomiej, Veenstra, Veronique L., Lecca, Maria C., Nijman, Lisanne E., van Dijk, Erik, van Neerven, Sanne M., Lodestijn, Sophie C., Lenos, Kristiaan J., de Groot, Nina E., Prasetyanti, Pramudita R., Varea, Andrea Arricibita, Winton, Douglas J., Medema, Jan Paul, Morrissey, Edward, Ylstra, Bauke, Nowak, Martin A., Bijlsma, Maarten F., Vermeulen, Louis
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2019)
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Journal Article
Chromosomal copy number heterogeneity predicts survival rates across cancers
van Dijk, Erik, van den Bosch, Tom, Lenos, Kristiaan J., El Makrini, Khalid, Nijman, Lisanne E., van Essen, Hendrik F. B., Lansu, Nico, Boekhout, Michiel, Hageman, Joris H., Fitzgerald, Rebecca C., Punt, Cornelis J. A., Tuynman, Jurriaan B., Snippert, Hugo J. G., Kops, Geert J. P. L., Medema, Jan Paul, Ylstra, Bauke, Vermeulen, Louis, Miedema, Daniël M.
Published in Nature communications (27.05.2021)
Published in Nature communications (27.05.2021)
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Journal Article
Using picoliter droplet deposition to track clonal competition in adherent and organoid cancer cell cultures
Baglamis, Selami, Sheraton, Vivek M, Meijer, Debora, Qian, Haibin, Hoebe, Ron A, Lenos, Kristiaan J, Betjes, Max A, Tans, Sander, van Zon, Jeroen, Vermeulen, Louis, Krawczyk, Przemek M
Published in Scientific reports (01.11.2023)
Published in Scientific reports (01.11.2023)
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Journal Article
T-cell responses in colorectal peritoneal metastases are recapitulated in a humanized immune system mouse model
Saris, Job, Bootsma, Sanne, Verhoeff, Jan, Tuynman, Jurriaan B., Wildenberg, Manon E., Rijnstra, Esther Siteur-van, Lenos, Kristiaan J., Garcia Vallejo, Juan J., Vermeulen, Louis, Grootjans, Joep
Published in Frontiers in immunology (09.07.2024)
Published in Frontiers in immunology (09.07.2024)
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Journal Article
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas
Lodestijn, Sophie C., van den Bosch, Tom, Nijman, Lisanne E., Moreno, Leandro F., Schlingemann, Sophie, Sheraton, Vivek M., van Neerven, Sanne M., Koning, Jasper J., Vieira Braga, Felipe A., Paauw, Nanne J., Lecca, Maria C., Lenos, Kristiaan J., Morrissey, Edward, Miedema, Daniël M., Winton, Douglas J., Bijlsma, Maarten F., Vermeulen, Louis
Published in Cell stem cell (04.11.2021)
Published in Cell stem cell (04.11.2021)
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Journal Article
Real‐time analysis of the cancer genome and fragmentome from plasma and urine cell‐free DNA using nanopore sequencing
Pol, Ymke, Tantyo, Normastuti Adhini, Evander, Nils, Hentschel, Anouk E, Wever, Birgit MM, Ramaker, Jip, Bootsma, Sanne, Fransen, Marieke F, Lenos, Kristiaan J, Vermeulen, Louis, Schneiders, Famke L, Bahce, Idris, Nieuwenhuijzen, Jakko A, Steenbergen, Renske DM, Pegtel, D Michiel, Moldovan, Norbert, Mouliere, Florent
Published in EMBO molecular medicine (07.12.2023)
Published in EMBO molecular medicine (07.12.2023)
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A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity
Bastiaenen, Vivian P., Klaver, Charlotte E.L., van der Heijden, Maartje C.S., Nijman, Lisanne E., Lecca, Maria C., Tanis, Pieter J., Lenos, Kristiaan J., Vermeulen, Louis
Published in Laboratory investigation (01.11.2020)
Published in Laboratory investigation (01.11.2020)
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Journal Article
Lymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon Cancer
Küçükköse, Emre, Laoukili, Jamila, Gorelick, Alexander N., Degner, Sebastian, Laclé, Miangela M., van den Bent, Lotte, Peters, Niek A., Verheem, André, Hung, Wei-Ting, Frenkel, Nicola C., Wassenaar, Emma C.E., Lansu, Nico, Lenos, Kristiaan J., Vermeulen, Louis, Koopman, Miriam, Roodhart, Jeanine M.L., Kops, Geert J.P.L., Borel Rinkes, Inne H.M., Hagendoorn, Jeroen, Naxerova, Kamila, Kranenburg, Onno
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2023)
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2023)
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Journal Article
Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer
Lodestijn, Sophie C., Miedema, Daniël M., Lenos, Kristiaan J., Nijman, Lisanne E., Belt, Saskia C., El Makrini, Khalid, Lecca, Maria C., Waasdorp, Cynthia, van den Bosch, Tom, Bijlsma, Maarten F., Vermeulen, Louis
Published in Cell reports (Cambridge) (19.10.2021)
Published in Cell reports (Cambridge) (19.10.2021)
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Journal Article
A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue
Lenos, Kristiaan J, Lodestijn, Sophie C, Lyons, Scott K, Bijlsma, Maarten F, Miedema, Daniël M, Vermeulen, Louis
Published in Nature protocols (01.09.2019)
Published in Nature protocols (01.09.2019)
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Journal Article
Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
Buikhuisen, Joyce Y, Gomez Barila, Patricia M, Cameron, Kate, Suijkerbuijk, Saskia J E, Lieftink, Cor, di Franco, Simone, Krotenberg Garcia, Ana, Uceda Castro, Rebeca, Lenos, Kristiaan J, Nijman, Lisanne E, Torang, Arezo, Longobardi, Ciro, de Jong, Joan H, Dekker, Daniëlle, Stassi, Giorgio, Vermeulen, Louis, Beijersbergen, Roderick L, van Rheenen, Jacco, Huveneers, Stephan, Medema, Jan Paul
Published in Journal of experimental & clinical cancer research (03.03.2023)
Published in Journal of experimental & clinical cancer research (03.03.2023)
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Journal Article
Multi-modal cell-free DNA genomic and fragmentomic patterns enhance cancer survival and recurrence analysis
Moldovan, Norbert, van der Pol, Ymke, van den Ende, Tom, Boers, Dries, Verkuijlen, Sandra, Creemers, Aafke, Ramaker, Jip, Vu, Trang, Bootsma, Sanne, Lenos, Kristiaan J, Vermeulen, Louis, Fransen, Marieke F, Pegtel, Michiel, Bahce, Idris, van Laarhoven, Hanneke, Mouliere, Florent
Published in Cell reports. Medicine (16.01.2024)
Published in Cell reports. Medicine (16.01.2024)
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Journal Article
A consensus molecular subtypes classification strategy for clinical colorectal cancer tissues
de Back, Tim R, Wu, Tan, Schafrat, Pascale Jm, Ten Hoorn, Sanne, Tan, Miaomiao, He, Lingli, van Hooff, Sander R, Koster, Jan, Nijman, Lisanne E, Vink, Geraldine R, Beumer, Inès J, Elbers, Clara C, Lenos, Kristiaan J, Sommeijer, Dirkje W, Wang, Xin, Vermeulen, Louis
Published in Life science alliance (01.08.2024)
Published in Life science alliance (01.08.2024)
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Journal Article
HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity[S]
Phillips, Anna, Teunisse, Amina, Lam, Suzanne, Lodder, Kirsten, Darley, Matthew, Emaduddin, Muhammad, Wolf, Anja, Richter, Julia, de Lange, Job, Verlaan-de Vries, Matty, Lenos, Kristiaan, Böhnke, Anja, Bartel, Frank, Blaydes, Jeremy P., Jochemsen, Aart G.
Published in The Journal of biological chemistry (17.09.2010)
Published in The Journal of biological chemistry (17.09.2010)
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Journal Article
c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53
Zuckerman, Valentina, Lenos, Kristiaan, Popowicz, Grzegorz M., Silberman, Isabelle, Grossman, Tamar, Marine, Jean-Christophe, Holak, Tad A., Jochemsen, Aart G., Haupt, Ygal
Published in The Journal of biological chemistry (06.02.2009)
Published in The Journal of biological chemistry (06.02.2009)
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Journal Article
Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
Bootsma, Sanne, Dings, Mark P.G., Kesselaar, Job, Helderman, Roxan F.C.P.A., van Megesen, Kyah, Constantinides, Alexander, Moreno, Leandro Ferreira, Stelloo, Ellen, Scutigliani, Enzo M., Bokan, Bella, Torang, Arezo, van Hooff, Sander R., Zwijnenburg, Danny A., Wouters, Valérie M., van de Vlasakker, Vincent C.J., Galanos, Laskarina J.K., Nijman, Lisanne E., Logiantara, Adrian, Veenstra, Veronique L., Schlingemann, Sophie, van Piggelen, Sterre, van der Wel, Nicole, Krawczyk, Przemek M., Platteeuw, Johannes J., Tuynman, Jurriaan B., de Hingh, Ignace H., Klomp, Jan P.G., Oubrie, Arthur, Snaebjornsson, Petur, Medema, Jan Paul, Oei, Arlene L., Kranenburg, Onno, Elbers, Clara C., Lenos, Kristiaan J., Vermeulen, Louis, Bijlsma, Maarten F.
Published in Cell reports. Medicine (21.05.2024)
Published in Cell reports. Medicine (21.05.2024)
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Journal Article
Cancer stem cells: here, there, and everywhere
Lodestijn, Sophie C., Lenos, Kristiaan J., Miedema, Daniël M., Bijlsma, Maarten F., Vermeulen, Louis
Published in Molecular & cellular oncology (01.01.2019)
Published in Molecular & cellular oncology (01.01.2019)
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