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Garvie, Colin W., Wu, Xiaoyun, Papanastasiou, Malvina, Lee, Sooncheol, Fuller, James, Schnitzler, Gavin R., Horner, Steven W., Baker, Andrew, Zhang, Terry, Mullahoo, James P., Westlake, Lindsay, Hoyt, Stephanie H., Toetzl, Marcus, Ranaghan, Matthew J., de Waal, Luc, McGaunn, Joseph, Kaplan, Bethany, Piccioni, Federica, Yang, Xiaoping, Lange, Martin, Tersteegen, Adrian, Raymond, Donald, Lewis, Timothy A., Carr, Steven A., Cherniack, Andrew D., Lemke, Christopher T., Meyerson, Matthew, Greulich, Heidi
Published in Nature communications (16.07.2021)
Published in Nature communications (16.07.2021)
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Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers
Ito, Takahiro, Young, Michael J., Li, Ruitong, Jain, Sidharth, Wernitznig, Andreas, Krill-Burger, John M., Lemke, Christopher T., Monducci, Davide, Rodriguez, Diego J., Chang, Liang, Dutta, Sanjukta, Pal, Debjani, Paolella, Brenton R., Rothberg, Michael V., Root, David E., Johannessen, Cory M., Parida, Laxmi, Getz, Gad, Vazquez, Francisca, Doench, John G., Zamanighomi, Mahdi, Sellers, William R.
Published in Nature genetics (01.12.2021)
Published in Nature genetics (01.12.2021)
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Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex
Kwon, Jason J., Hajian, Behnoush, Bian, Yuemin, Young, Lucy C., Amor, Alvaro J., Fuller, James R., Fraley, Cara V., Sykes, Abbey M., So, Jonathan, Pan, Joshua, Baker, Laura, Lee, Sun Joo, Wheeler, Douglas B., Mayhew, David L., Persky, Nicole S., Yang, Xiaoping, Root, David E., Barsotti, Anthony M., Stamford, Andrew W., Perry, Charles K., Burgin, Alex, McCormick, Frank, Lemke, Christopher T., Hahn, William C., Aguirre, Andrew J.
Published in Nature (London) (08.09.2022)
Published in Nature (London) (08.09.2022)
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Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics
Ho, Richard H, Tirona, Rommel G, Leake, Brenda F, Glaeser, Hartmut, Lee, Wooin, Lemke, Christopher J, Wang, Yi, Kim, Richard B
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2006)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2006)
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Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes
LAMORTE, Louie, TITOLO, Steve, AIKEN, Christopher, SUNDQUIST, Wesley I, MASON, Stephen W, LEMKE, Christopher T, GOUDREAU, Nathalie, MERCIER, Jean-François, WARDROP, Elizabeth, SHAH, Vaibhav B, VON SCHWEDLER, Uta K, LANGELIER, Charles, BANIK, Soma S. R
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
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Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins
Knauer, Michael J, Urquhart, Bradley L, Meyer zu Schwabedissen, Henriette E, Schwarz, Ute I, Lemke, Christopher J, Leake, Brenda F, Kim, Richard B, Tirona, Rommel G
Published in Circulation research (05.02.2010)
Published in Circulation research (05.02.2010)
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Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069
Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers
Rubinson, Douglas A, Tanaka, Noritaka, Fece de la Cruz, Ferran, Kapner, Kevin S, Rosenthal, Michael H, Norden, Bryanna L, Barnes, Haley, Ehnstrom, Sara, Morales-Giron, Alvin A, Brais, Lauren K, Lemke, Christopher T, Aguirre, Andrew J, Corcoran, Ryan B
Published in Cancer discovery (01.05.2024)
Published in Cancer discovery (01.05.2024)
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Ligand Bioactive Conformation Plays a Critical Role in the Design of Drugs That Target the Hepatitis C Virus NS3 Protease
LaPlante, Steven R., Nar, Herbert, Lemke, Christopher T., Jakalian, Araz, Aubry, Norman, Kawai, Stephen H.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein
LEMKE, Christopher T, TITOLO, Steve, GAGNON, Alexandre, KAWAI, Stephen H, RANCOURT, Jean, TREMBLAY, Martin, YOAKIM, Christiane, SIMONEAU, Bruno, ARCHAMBAULT, Jacques, SUNDQUIST, Wesley I, MASON, Stephen W, VON SCHWEDLER, Uta, GOUDREAU, Nathalie, MERCIER, Jean-François, WARDROP, Elizabeth, FAUCHER, Anne-Marie, COULOMBE, Rene, BANIK, Soma S. R, FADER, Lee
Published in Journal of Virology (01.06.2012)
Published in Journal of Virology (01.06.2012)
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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
Babbe, Holger, Sundberg, Thomas B, Tichenor, Mark, Seierstad, Mark, Bacani, Genesis, Berstler, James, Chai, Wenying, Chang, Leon, Chung, De Michael, Coe, Kevin, Collins, Bernard, Finley, Michael, Guletsky, Alexander, Lemke, Christopher T, Mak, Puiying A, Mathur, Ashok, Mercado-Marin, Eduardo V, Metkar, Shailesh, Raymond, Donald D, Rives, Marie-Laure, Rizzolio, Michele, Shaffer, Paul L, Smith, Russell, Smith, Jacqueline, Steele, Ruth, Steffens, Helena, Suarez, Javier, Tian, Gaochao, Majewski, Nathan, Volak, Laurie P, Wei, Jianmei, Desai, Prerak T, Ong, Luvena L, Koudriakova, Tatiana, Goldberg, Steven D, Hirst, Gavin, Kaushik, Virendar K, Ort, Tatiana, Seth, Nilufer, Graham, Daniel B, Plevy, Scott, Venable, Jennifer D, Xavier, Ramnik J, Towne, Jennifer E
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
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Correction to “Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069”
Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists
Orsi, Douglas L., Ferrara, Steven J., Siegel, Stephan, Friberg, Anders, Bouché, Léa, Pook, Elisabeth, Lienau, Philip, Bluck, Joseph P., Lemke, Christopher T., Akcay, Gizem, Stellfeld, Timo, Meyer, Hanna, Pütter, Vera, Holton, Simon J., Korr, Daniel, Jerchel-Furau, Isabel, Pantelidou, Constantia, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Bioorganic & medicinal chemistry (15.01.2023)
Published in Bioorganic & medicinal chemistry (15.01.2023)
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Multimodal small-molecule screening for human prion protein binders
Reidenbach, Andrew G., Mesleh, Michael F., Casalena, Dominick, Vallabh, Sonia M., Dahlin, Jayme L., Leed, Alison J., Chan, Alix I., Usanov, Dmitry L., Yehl, Jenna B., Lemke, Christopher T., Campbell, Arthur J., Shah, Rishi N., Shrestha, Om K., Sacher, Joshua R., Rangel, Victor L., Moroco, Jamie A., Sathappa, Murugappan, Nonato, Maria Cristina, Nguyen, Kong T., Wright, S. Kirk, Liu, David R., Wagner, Florence F., Kaushik, Virendar K., Auld, Douglas S., Schreiber, Stuart L., Minikel, Eric Vallabh
Published in The Journal of biological chemistry (25.09.2020)
Published in The Journal of biological chemistry (25.09.2020)
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Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly
Fader, Lee D., Bethell, Richard, Bonneau, Pierre, Bös, Michael, Bousquet, Yves, Cordingley, Michael G., Coulombe, René, Deroy, Patrick, Faucher, Anne-Marie, Gagnon, Alexandre, Goudreau, Nathalie, Grand-Maître, Chantal, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lacoste, Jean-Eric, Landry, Serge, Lemke, Christopher T., Malenfant, Eric, Mason, Stephen, Morin, Sébastien, O’Meara, Jeff, Simoneau, Bruno, Titolo, Steve, Yoakim, Christiane
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335
Lemke, Christopher T., Goudreau, Nathalie, Zhao, Songping, Hucke, Oliver, Thibeault, Diane, Llinàs-Brunet, Montse, White, Peter W.
Published in The Journal of biological chemistry (01.04.2011)
Published in The Journal of biological chemistry (01.04.2011)
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A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization
Lemke, Christopher T., Titolo, Steve, Goudreau, Nathalie, Faucher, Anne-Marie, Mason, Stephen W., Bonneau, Pierre
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2013)
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2013)
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Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity
LaPlante, Steven R., Forgione, Pat, Boucher, Colette, Coulombe, René, Gillard, James, Hucke, Oliver, Jakalian, Araz, Joly, Marc-André, Kukolj, George, Lemke, Christopher, McCollum, Robert, Titolo, Steve, Beaulieu, Pierre L., Stammers, Timothy
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models
Rauh, Ulrike, Wei, Guo, Serrano-Wu, Michael, Kosmidis, Georgios, Kaulfuss, Stefan, Siegel, Franziska, Thede, Kai, McFarland, James, Lemke, Christopher T., Werbeck, Nicolas, Nowak-Reppel, Katrin, Pilari, Sabine, Menz, Stephan, Ocker, Matthias, Zhang, Weiqun, Davis, Kyle, Poncet-Montange, Guillaume, Roth, Jennifer, Daniels, Douglas, Kaushik, Virendar K., Hubbard, Brian, Ziegelbauer, Karl, Golub, Todd R.
Published in Nature cancer (23.08.2024)
Published in Nature cancer (23.08.2024)
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