Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers
Wagner, F F, Zhang, Y-L, Fass, D M, Joseph, N, Gale, J P, Weïwer, M, McCarren, P, Fisher, S L, Kaya, T, Zhao, W-N, Reis, S A, Hennig, K M, Thomas, M, Lemercier, B C, Lewis, M C, Guan, J S, Moyer, M P, Scolnick, E, Haggarty, S J, Tsai, L-H, Holson, E B
Published in Chemical science (Cambridge) (01.01.2015)
Published in Chemical science (Cambridge) (01.01.2015)
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Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancersElectronic supplementary information (ESI) available: Compound synthesis and characterization; 1HNMR spectra, HPLC or UPLC spectral traces; HDAC enzymatic assay protocol; IC50s for representative compounds for HDACs 1-9; full kinetic parameters for BRD4884 and BRD6688; progression and dissociation curves for BRD6688; pharmacokinetic graphs and parameters for representative compounds; kinetic selectivity profi
Wagner, F. F, Zhang, Y.-L, Fass, D. M, Joseph, N, Gale, J. P, Weïwer, M, McCarren, P, Fisher, S. L, Kaya, T, Zhao, W.-N, Reis, S. A, Hennig, K. M, Thomas, M, Lemercier, B. C, Lewis, M. C, Guan, J. S, Moyer, M. P, Scolnick, E, Haggarty, S. J, Tsai, L.-H, Holson, E. B
Year of Publication 01.12.2014
Year of Publication 01.12.2014
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Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers† †Electronic supplementary information (ESI) available: Compound synthesis and characterization; 1HNMR spectra, HPLC or UPLC spectral traces; HDAC enzymatic assay protocol; IC50s for representative compounds for HDACs 1–9; full kinetic parameters for BRD4884 and BRD6688; progression and dissociation curves for BRD6688; pharmacokinetic graphs and parameters for representative compounds; kinetic selectivity pr
Wagner, F. F., Zhang, Y.-L., Fass, D. M., Joseph, N., Gale, J. P., Weïwer, M., McCarren, P., Fisher, S. L., Kaya, T., Zhao, W.-N., Reis, S. A., Hennig, K. M., Thomas, M., Lemercier, B. C., Lewis, M. C., Guan, J. S., Moyer, M. P., Scolnick, E., Haggarty, S. J., Tsai, L.-H., Holson, E. B.
Published in Chemical science (Cambridge) (09.10.2014)
Published in Chemical science (Cambridge) (09.10.2014)
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