Search Results - "Lelais, Gérald" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of (R,E)‑N‑(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)‑1H‑benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

Discovery of (R,E)‑N‑(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)‑1H‑benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

by Lelais, Gérald, Epple, Robert, Marsilje, Thomas H, Long, Yun O, McNeill, Matthew, Chen, Bei, Lu, Wenshuo, Anumolu, Jaganmohan, Badiger, Sangamesh, Bursulaya, Badry, DiDonato, Michael, Fong, Rina, Juarez, Jose, Li, Jie, Manuia, Mari, Mason, Daniel E, Gordon, Perry, Groessl, Todd, Johnson, Kevin, Jia, Yong, Kasibhatla, Shailaja, Li, Chun, Isbell, John, Spraggon, Glen, Bender, Steven, Michellys, Pierre-Yves
Published in Journal of medicinal chemistry (28.07.2016)

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Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology

Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology

by Kingsley, Laura J, He, Xiaohui, McNeill, Matthew, Nelson, John, Nikulin, Victor, Ma, Zhiwei, Lu, Wenshuo, Zhou, Vicki W, Manuia, Mari, Kreusch, Andreas, Gao, Mu-Yun, Witmer, Darbi, Vaillancourt, Mei-Ting, Lu, Min, Greenblatt, Sarah, Lee, Christian, Vashisht, Ajay, Bender, Steven, Spraggon, Glen, Michellys, Pierre-Yves, Jia, Yong, Haling, Jacob R, Lelais, Gérald
Published in Journal of medicinal chemistry (22.04.2021)

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EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

by Jia, Yong, Juarez, Jose, Li, Jie, Manuia, Mari, Niederst, Matthew J, Tompkins, Celin, Timple, Noelito, Vaillancourt, Mei-Ting, Pferdekamper, AnneMarie Culazzo, Lockerman, Elizabeth L, Li, Chun, Anderson, Jennifer, Costa, Carlotta, Liao, Debbie, Murphy, Eric, DiDonato, Michael, Bursulaya, Badry, Lelais, Gerald, Barretina, Jordi, McNeill, Matthew, Epple, Robert, Marsilje, Thomas H, Pathan, Nuzhat, Engelman, Jeffrey A, Michellys, Pierre-Yves, McNamara, Peter, Harris, Jennifer, Bender, Steven, Kasibhatla, Shailaja
Published in Cancer research (Chicago, Ill.) (15.03.2016)

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Synthesis, CD Spectra, and Enzymatic Stability of β2-Oligoazapeptides Prepared from (S)-2-Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and Leu

Synthesis, CD Spectra, and Enzymatic Stability of β2-Oligoazapeptides Prepared from (S)-2-Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and Leu

by Lelais, Gérald, Seebach, Dieter
Published in Helvetica chimica acta (01.12.2003)

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Preparation of Protected β2- and β3-Homocysteine, β2- and β3-Homohistidine, and β2-Homoserine for Solid-Phase Syntheses

Preparation of Protected β2- and β3-Homocysteine, β2- and β3-Homohistidine, and β2-Homoserine for Solid-Phase Syntheses

by Lelais, Gérald, Micuch, Peter, Josien-Lefebvre, Delphine, Rossi, Francesco, Seebach, Dieter
Published in Helvetica chimica acta (01.12.2004)

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Integrating pharmacokinetic-pharmacodynamic modeling in preclinical assessment of mutant selective EGFR covalent tyrosine kinase inhibitor EGF816

Integrating pharmacokinetic-pharmacodynamic modeling in preclinical assessment of mutant selective EGFR covalent tyrosine kinase inhibitor EGF816

by Li, Chun, Jia, Yong, Lelais, Gerald, Li, Jie, Shapiro, Michael, Groessl, Todd, Vaillancourt, Mei-Ting, Tompkins, Celin, Tuntland, Tove, Isbell, John, Bender, Steve, Cui, Xiaoming
Published in Drug metabolism and pharmacokinetics (01.01.2019)

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Discovery of ( R , E )- N -(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1 H -benzo[ d ]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

Discovery of ( R , E )- N -(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1 H -benzo[ d ]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

by Lelais, Gérald, Epple, Robert, Marsilje, Thomas H., Long, Yun O., McNeill, Matthew, Chen, Bei, Lu, Wenshuo, Anumolu, Jaganmohan, Badiger, Sangamesh, Bursulaya, Badry, DiDonato, Michael, Fong, Rina, Juarez, Jose, Li, Jie, Manuia, Mari, Mason, Daniel E., Gordon, Perry, Groessl, Todd, Johnson, Kevin, Jia, Yong, Kasibhatla, Shailaja, Li, Chun, Isbell, John, Spraggon, Glen, Bender, Steven, Michellys, Pierre-Yves
Published in Journal of medicinal chemistry (28.07.2016)

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Synthesis, CD spectra, and enzymatic stability of beta(2)-oligoazapeptides prepared from (S)-2-hydrazino carboxylic acids carrying the side chains of Val, Ala, and Leu

Synthesis, CD spectra, and enzymatic stability of beta(2)-oligoazapeptides prepared from (S)-2-hydrazino carboxylic acids carrying the side chains of Val, Ala, and Leu

by Lelais, G, Seebach, D
Published in Helvetica chimica acta (01.01.2003)

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Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

by Jia, Yong, Yun, Cai-Hong, Park, Eunyoung, Ercan, Dalia, Manuia, Mari, Juarez, Jose, Xu, Chunxiao, Rhee, Kevin, Chen, Ting, Zhang, Haikuo, Palakurthi, Sangeetha, Jang, Jaebong, Lelais, Gerald, DiDonato, Michael, Bursulaya, Badry, Michellys, Pierre-Yves, Epple, Robert, Marsilje, Thomas H., McNeill, Matthew, Lu, Wenshuo, Harris, Jennifer, Bender, Steven, Wong, Kwok-Kin, Jänne, Pasi A., Eck, Michael J.
Published in Nature (London) (02.06.2016)

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β 2 ‐amino acids—syntheses, occurrence in natural products, and components of β‐peptides 1,2

β 2 ‐amino acids—syntheses, occurrence in natural products, and components of β‐peptides 1,2

by Lelais, Gérald, Seebach, Dieter
Published in Peptide Science (01.01.2004)

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Beta2-amino acids-syntheses, occurrence in natural products, and components of beta-peptides1,2

Beta2-amino acids-syntheses, occurrence in natural products, and components of beta-peptides1,2

by Lelais, Gérald, Seebach, Dieter
Published in Biopolymers (2004)

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Journal Article

β2-amino acids-syntheses, occurrence in natural products, and components of β-peptides1,2

β2-amino acids-syntheses, occurrence in natural products, and components of β-peptides1,2

by Lelais, Gérald, Seebach, Dieter
Published in Peptide Science (2004)

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Journal Article

Synthesis, CD Spectra, and Enzymatic Stability of β 2 ‐Oligoazapeptides Prepared from ( S )‐2‐Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and Leu

Synthesis, CD Spectra, and Enzymatic Stability of β 2 ‐Oligoazapeptides Prepared from ( S )‐2‐Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and Leu

by Lelais, Gérald, Seebach, Dieter
Published in Helvetica chimica acta (01.12.2003)

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Development of a virtual reality platform for effective communication of structural data in drug discovery

Development of a virtual reality platform for effective communication of structural data in drug discovery

by Kingsley, Laura J., Brunet, Vincent, Lelais, Gerald, McCloskey, Steve, Milliken, Kelly, Leija, Edgardo, Fuhs, Stephen R., Wang, Kai, Zhou, Edward, Spraggon, Glen
Published in Journal of molecular graphics & modelling (01.06.2019)

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Mixed beta(2)/beta(3)-hexapeptides and beta(2)/beta(3)-nonapeptides folding to (P)-helices with alternating twelve- and ten-membered hydrogen-bonded rings

Mixed beta(2)/beta(3)-hexapeptides and beta(2)/beta(3)-nonapeptides folding to (P)-helices with alternating twelve- and ten-membered hydrogen-bonded rings

by Rueping, M, Schreiber, JV, Lelais, G, Jaun, B, Seebach, D
Published in Helvetica chimica acta (01.01.2002)

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beta-Peptidic secondary structures fortified and enforced by Zn2+ complexation - On the way to beta-peptidic zinc fingers?

beta-Peptidic secondary structures fortified and enforced by Zn2+ complexation - On the way to beta-peptidic zinc fingers?

by Lelais, G, Seebach, D, Jaun, B, Mathad, RI, Flogel, O, Rossi, F, Campo, M, Wortmann, A
Published in Helvetica chimica acta (01.03.2006)

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Preparation of protected beta(2)- and beta(3)-homocysteine, beta(2)- and beta(3)-homohistidine, and beta(2)-homoserine for solid-phase syntheses

Preparation of protected beta(2)- and beta(3)-homocysteine, beta(2)- and beta(3)-homohistidine, and beta(2)-homoserine for solid-phase syntheses

by Lelais, G, Micuch, P, Josien-Lefebvre, D, Rossi, F, Seebach, D
Published in Helvetica chimica acta (01.01.2004)

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Zn2+-Complexation by a β-Peptidic Helix and Hairpin Containing β3hCys and β3hHis Building Blocks: Evidence from CD Measurements. Preliminary Communication

Zn2+-Complexation by a β-Peptidic Helix and Hairpin Containing β3hCys and β3hHis Building Blocks: Evidence from CD Measurements. Preliminary Communication

by Rossi, Francesco, Lelais, Gérald, Seebach, Dieter
Published in Helvetica chimica acta (01.07.2003)

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Zn 2+ ‐Complexation by a β ‐Peptidic Helix and Hairpin Containing β 3 hCys and β 3 hHis Building Blocks: Evidence from CD Measurements. Preliminary Communication

Zn 2+ ‐Complexation by a β ‐Peptidic Helix and Hairpin Containing β 3 hCys and β 3 hHis Building Blocks: Evidence from CD Measurements. Preliminary Communication

by Rossi, Francesco, Lelais, Gérald, Seebach, Dieter
Published in Helvetica chimica acta (01.07.2003)

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Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling

Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling

by McAllister, Christopher S., Ansaldi, Dan, Growcott, Ellena J., Zhong, Yang, Quackenbush, Doug, Wolff, Karen C., Chen, Zhong, Tanaseichuk, Olga, Lelais, Gerald, Barnes, S. Whitney, Federe, Glenn C., Luna, Fabio, Walker, John R., Zhou, Yingyao, Kuhen, Kelli L.
Published in Virology (New York, N.Y.) (15.01.2020)

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