2-Oxoglutarate-Dependent Oxygenases
Islam, Md. Saiful, Leissing, Thomas M, Chowdhury, Rasheduzzaman, Hopkinson, Richard J, Schofield, Christopher J
Published in Annual review of biochemistry (20.06.2018)
Published in Annual review of biochemistry (20.06.2018)
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Journal Article
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
Yeh, Tzu-Lan, Leissing, Thomas M, Abboud, Martine I, Thinnes, Cyrille C, Atasoylu, Onur, Holt-Martyn, James P, Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T, Leung, Ivanhoe K H, Morcrette, Helen, Clifton, Ian J, Claridge, Timothy D W, Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J, Chowdhury, Rasheduzzaman, Pugh, Christopher W, Schofield, Christopher J
Published in Chemical science (Cambridge) (2017)
Published in Chemical science (Cambridge) (2017)
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Journal Article
Structure–function relationships of human JmjC oxygenases—demethylases versus hydroxylases
Markolovic, Suzana, Leissing, Thomas M, Chowdhury, Rasheduzzaman, Wilkins, Sarah E, Lu, Xin, Schofield, Christopher J
Published in Current opinion in structural biology (01.12.2016)
Published in Current opinion in structural biology (01.12.2016)
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Trineopentylphosphine: A Conformationally Flexible Ligand for the Coupling of Sterically Demanding Substrates in the Buchwald–Hartwig Amination and Suzuki–Miyaura Reaction
Raders, Steven M, Moore, Jane N, Parks, Jacquelynn K, Miller, Ashley D, Leißing, Thomas M, Kelley, Steven P, Rogers, Robin D, Shaughnessy, Kevin H
Published in Journal of organic chemistry (17.05.2013)
Published in Journal of organic chemistry (17.05.2013)
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Journal Article
Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli
Lang, Pauline A, Parkova, Anete, Leissing, Thomas M, Calvopiña, Karina, Cain, Ricky, Krajnc, Alen, Panduwawala, Tharindi D, Philippe, Jules, Fishwick, Colin W G, Trapencieris, Peteris, Page, Malcolm G P, Schofield, Christopher J, Brem, Jürgen
Published in Biomolecules (Basel, Switzerland) (12.06.2020)
Published in Biomolecules (Basel, Switzerland) (12.06.2020)
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Journal Article
Anaerobic fixed-target serial crystallography
Rabe, Patrick, Beale, John H, Butryn, Agata, Aller, Pierre, Dirr, Anna, Lang, Pauline A, Axford, Danny N, Carr, Stephen B, Leissing, Thomas M, McDonough, Michael A, Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L.S, Orville, Allen M, Schofield, Christopher J, Owen, Robin L
Published in IUCrJ (01.09.2020)
Published in IUCrJ (01.09.2020)
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Journal Article
CagA–ASPP2 complex mediates loss of cell polarity and favors H. pylori colonization of human gastric organoids
Buti, Ludovico, Ruiz-Puig, Carlos, Sangberg, Dennis, Leissing, Thomas M., Brewer, R. Camille, Owen, Richard P., Sgromo, Bruno, Royer, Christophe, Ebner, Daniel, Lu, Xin
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2020)
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Journal Article
HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity
Sulser, Pascale, Pickel, Christina, Günter, Julia, Leissing, Thomas M, Crean, Daniel, Schofield, Christopher J, Wenger, Roland H, Scholz, Carsten C
Published in The FASEB journal (01.02.2020)
Published in The FASEB journal (01.02.2020)
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Journal Article
Structure driven compound optimization in targeted protein degradation
Leissing, Thomas M., Luh, Laura M., Cromm, Philipp M.
Published in Drug discovery today. Technologies (01.12.2020)
Published in Drug discovery today. Technologies (01.12.2020)
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Journal Article
Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains
Saward, Benjamin G., Leissing, Thomas M., Clifton, Ian J., Tumber, Anthony, Timperley, Christopher M., Hopkinson, Richard J., Schofield, Christopher J.
Published in Chembiochem : a European journal of chemical biology (14.02.2023)
Published in Chembiochem : a European journal of chemical biology (14.02.2023)
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Journal Article
Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins
Leissing, Thomas M., Hardy, Adam P., Chan, Hokfung, Wang, Yihua, Tumber, Anthony, Chowdhury, Rasheduzzaman, Feng, Tianshu, Coleman, Mathew L., Cockman, Matthew E., Kramer, Holger B., Berridge, Georgina, Fischer, Roman, Kessler, Benedikt M., Ratcliffe, Peter J., Lu, Xin, Schofield, Christopher J.
Published in The Journal of biological chemistry (01.06.2022)
Published in The Journal of biological chemistry (01.06.2022)
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Journal Article
Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment
Ma, Jingyi, Al Moussawi, Khatoun, Lou, Hantao, Chan, Hok Fung, Wang, Yihua, Chadwick, Joseph, Phetsouphanh, Chansavath, Slee, Elizabeth A, Zhong, Shan, Leissing, Thomas M, Roth, Andrew, Qin, Xiao, Chen, Shuo, Yin, Jie, Ratnayaka, Indrika, Hu, Yang, Louphrasitthiphol, Pakavarin, Taylor, Lewis, Bettencourt, Paulo J G, Muers, Mary, Greaves, David R, McShane, Helen, Goldin, Robert, Soilleux, Elizabeth J, Coleman, Mathew L, Ratcliffe, Peter J, Lu, Xin
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2024)
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Journal Article
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors
Shishodia, Shifali, Demetriades, Marina, Zhang, Dong, Tam, Nok Yin, Maheswaran, Pratheesh, Clunie-O’Connor, Caitlin, Tumber, Anthony, Leung, Ivanhoe K. H, Ng, Yi Min, Leissing, Thomas M, El-Sagheer, Afaf H, Salah, Eidarus, Brown, Tom, Aik, Wei Shen, McDonough, Michael A, Schofield, Christopher J
Published in Journal of medicinal chemistry (25.11.2021)
Published in Journal of medicinal chemistry (25.11.2021)
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Journal Article
X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
Rabe, Patrick, Kamps, Jos J A G, Sutherlin, Kyle D, Linyard, James D S, Aller, Pierre, Pham, Cindy C, Makita, Hiroki, Clifton, Ian, McDonough, Michael A, Leissing, Thomas M, Shutin, Denis, Lang, Pauline A, Butryn, Agata, Brem, Jürgen, Gul, Sheraz, Fuller, Franklin D, Kim, In-Sik, Cheah, Mun Hon, Fransson, Thomas, Bhowmick, Asmit, Young, Iris D, O'Riordan, Lee, Brewster, Aaron S, Pettinati, Ilaria, Doyle, Margaret, Joti, Yasumasa, Owada, Shigeki, Tono, Kensuke, Batyuk, Alexander, Hunter, Mark S, Alonso-Mori, Roberto, Bergmann, Uwe, Owen, Robin L, Sauter, Nicholas K, Claridge, Timothy D W, Robinson, Carol V, Yachandra, Vittal K, Yano, Junko, Kern, Jan F, Orville, Allen M, Schofield, Christopher J
Published in Science advances (01.08.2021)
Published in Science advances (01.08.2021)
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Journal Article
A human protein hydroxylase that accepts D-residues
Choi, Hwanho, Hardy, Adam P, Leissing, Thomas M, Chowdhury, Rasheduzzaman, Nakashima, Yu, Ge, Wei, Markoulides, Marios, Scotti, John S, Gerken, Philip A, Thorbjornsrud, Helen, Kang, Dahye, Hong, Sungwoo, Lee, Joongoo, McDonough, Michael A, Park, Hwangseo, Schofield, Christopher J
Published in Communications chemistry (01.05.2020)
Published in Communications chemistry (01.05.2020)
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Journal Article
Imitation of beta-lactam binding enables broad-spectrum metallo-beta-lactamase inhibitors
Brem, Jurgen, Panduwawala, Tharindi, Hansen, Jon Ulf, Hewitt, Joanne, Liepins, Edgars, Donets, Pawel, Espina, Laura, Farley, Alistair J. M., Shubin, Kirill, Campillos, Gonzalo Gomez, Kiuru, Paula, Shishodia, Shifali, Krahn, Daniel, Lesniak, Robert K., Schmidt (Adrian), Juliane, Calvopina, Karina, Turrientes, Maria-Carmen, Kavanagh, Madeline E., Lubriks, Dmitrijs, Hinchliffe, Philip, Langley, Gareth W., Aboklaish, Ali F., Eneroth, Anders, Backlund, Maria, Baran, Andrei G., Nielsen, Elisabet, Speake, Michael, Kuka, Janis, Robinson, John, Grinberga, Solveiga, Robinson, Lindsay, McDonough, Michael A., Rydzik, Anna M., Leissing, Thomas M., Jimenez-Castellanos, Juan Carlos, Avison, Matthew B., Pinto, Solange Da Silva, Pannifer, Andrew D., Martjuga, Marina, Widlake, Emma, Priede, Martins, Navratilova, Iva Hopkins, Gniadkowski, Marek, Belfrage, Anna Karin, Brandt, Peter, Yli-Kauhaluoma, Jari, Bacque, Eric, Page, Malcolm G. P., Bjorkling, Fredrik, Tyrrell, Jonathan M., Spencer, James, Lang, Pauline A., Baranczewski, Pawel, Canton, Rafael, McElroy, Stuart P., Jones, Philip S., Baquero, Fernando, Suna, Edgars, Morrison, Angus, Walsh, Timothy R., Schofield, Christopher J.
Published in Nature chemistry (01.01.2022)
Published in Nature chemistry (01.01.2022)
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Journal Article
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trialsElectronic supplementary information (ESI) available: Synthetic procedures; supplementary methods including NMR, OGFOD1/Tpa1a/OFD1/PHD2/FIH hydroxylation assays, cell culture and immunoblotting, RT-qPCR assays and cell viability assays; supplementary figures; supplementary tables. See DOI: 10.1039/c7sc02103h
Yeh, Tzu-Lan, Leissing, Thomas M, Abboud, Martine I, Thinnes, Cyrille C, Atasoylu, Onur, Holt-Martyn, James P, Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T, Leung, Ivanhoe K. H, Morcrette, Helen, Clifton, Ian J, Claridge, Timothy D. W, Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J, Chowdhury, Rasheduzzaman, Pugh, Christopher W, Schofield, Christopher J
Year of Publication 23.10.2017
Year of Publication 23.10.2017
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Journal Article
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials† †Electronic supplementary information (ESI) available: Synthetic procedures; supplementary methods including NMR, OGFOD1/Tpa1a/OFD1/PHD2/FIH hydroxylation assays, cell culture and immunoblotting, RT-qPCR assays and cell viability assays; supplementary figures; supplementary tables. See DOI: 10.1039/c7sc02103h
Yeh, Tzu-Lan, Leissing, Thomas M., Abboud, Martine I., Thinnes, Cyrille C., Atasoylu, Onur, Holt-Martyn, James P., Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T., Leung, Ivanhoe K. H., Morcrette, Helen, Clifton, Ian J., Claridge, Timothy D. W., Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J., Chowdhury, Rasheduzzaman, Pugh, Christopher W., Schofield, Christopher J.
Published in Chemical science (Cambridge) (11.09.2017)
Published in Chemical science (Cambridge) (11.09.2017)
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Journal Article
Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C [beta]-Lactamase from Escherichia coli
Lang, Pauline A, Parkova, Anete, Leissing, Thomas M, Calvopina, Karina, Cain, Ricky, Krajnc, Alen, Panduwawala, Tharindi D, Philippe, Jules, Fishwick, Colin W.G, Trapencieris, Peteris, Page, Malcolm G.P, Schofield, Christopher J, Brem, Jurgen
Published in Biomolecules (Basel, Switzerland) (01.06.2020)
Published in Biomolecules (Basel, Switzerland) (01.06.2020)
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