Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species
Yip, Victor, Saad, Ola M, Leipold, Doug, Li, Chunze, Kamath, Amrita, Shen, Ben-Quan
Published in Xenobiotica (13.09.2024)
Published in Xenobiotica (13.09.2024)
Get more information
Journal Article
Anti-Lymphocyte Antigen 6 Complex, Locus E- Seco -Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α 1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
Yip, Victor, Figueroa, Isabel, Latifi, Brandon, Masih, Shab, Ng, Carl, Leipold, Doug, Kamath, Amrita, Shen, Ben-Quan
Published in Drug metabolism and disposition (01.12.2020)
Published in Drug metabolism and disposition (01.12.2020)
Get full text
Journal Article
Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity
Wei, BinQing, Gunzner-Toste, Janet, Yao, Hui, Wang, Tao, Wang, Jing, Xu, Zijin, Chen, Jinhua, Wai, John, Nonomiya, Jim, Tsai, Siao Ping, Chuh, Josefa, Kozak, Katherine R, Liu, Yichin, Yu, Shang-Fan, Lau, Jeff, Li, Guangmin, Phillips, Gail D, Leipold, Doug, Kamath, Amrita, Su, Dian, Xu, Keyang, Eigenbrot, Charles, Steinbacher, Stefan, Ohri, Rachana, Raab, Helga, Staben, Leanna R, Zhao, Guiling, Flygare, John A, Pillow, Thomas H, Verma, Vishal, Masterson, Luke A, Howard, Philip W, Safina, Brian
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
Get full text
Journal Article
Abstract P167: Site-specific Dolasynthen ADCs demonstrate consistent exposure across a wide range of drug-to-antibody ratios
Catcott, Kalli C., Clardy, Susan, Sadowsky, Jack, Rowntree, Rebecca K., Centibas, Naniye Malli, Xu, Ling, Polson, Andy, Avocetien, Kenneth, Carter, Tyler, Nazzaro, Mark, Kim, Dokyong "DK", Pillow, Thomas H., Zacharias, Neelie, Wu, Cong, Zurita, Jeffrey, Ditty, Elizabeth, Bradley, Stephen, Uttard, Alex, Du, Bingfan, Sawyer, William S., Leipold, Doug, Phillips, Gail Lewis, Qin, LiuLiang, Slocum, Kelly, Rosario, Geoffrey Del, Li, Ginny, Yu, Shang-Fan, Lee, David, Iyengar, Radha, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
Get full text
Journal Article
Abstract CT009: Targeting MUC16 with the THIOMABTM-drug conjugate DMUC4064A in patients with platinum-resistant ovarian cancer: a Phase I escalation study
Liu, Joyce F., Moore, Kathleen N., Wang, Judy S., Patel, Manish, Birrer, Michael J., Hamilton, Erika, Barroilhet, Lisa, Flanagan, William M., Wang, Yulei, Garg, Amit, Lu, Xuyang, Vaze, Anjali, Amin, Dilip, Leipold, Doug, Commerford, S Renee, Humke, Eric W., Burris, Harold A.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC
Figueroa, Isabel, Leipold, Doug, Leong, Steve, Zheng, Bing, Triguero-Carrasco, Montserrat, Fourie-O'Donohue, Aimee, Kozak, Katherine R, Xu, Keyang, Schutten, Melissa, Wang, Hong, Polson, Andrew G, Kamath, Amrita V
Published in mAbs (04.07.2018)
Published in mAbs (04.07.2018)
Get full text
Journal Article
Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC
Figueroa, Isabel, Leipold, Doug, Leong, Steve, Zheng, Bing, Triguero-Carrasco, Montserrat, Fourie-O'Donohue, Aimee, Kozak, Katherine R., Xu, Keyang, Schutten, Melissa, Wang, Hong, Polson, Andrew G., Kamath, Amrita V.
Published in mAbs (04.07.2018)
Published in mAbs (04.07.2018)
Get full text
Report