The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
Kansanen, Emilia, Kuosmanen, Suvi M, Leinonen, Hanna, Levonen, Anna-Liisa
Published in Redox biology (01.01.2013)
Published in Redox biology (01.01.2013)
Get full text
Journal Article
Dysregulation of the Keap1-Nrf2 pathway in cancer
Leinonen, Hanna M, Kansanen, Emilia, Pölönen, Petri, Heinäniemi, Merja, Levonen, Anna-Liisa
Published in Biochemical Society transactions (01.08.2015)
Published in Biochemical Society transactions (01.08.2015)
Get more information
Journal Article
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Pölönen, Petri, Jawahar Deen, Ashik, Leinonen, Hanna M., Jyrkkänen, Henna-Kaisa, Kuosmanen, Suvi, Mononen, Mimmi, Jain, Ashish, Tuomainen, Tomi, Pasonen-Seppänen, Sanna, Hartikainen, Jaana M., Mannermaa, Arto, Nykter, Matti, Tavi, Pasi, Johansen, Terje, Heinäniemi, Merja, Levonen, Anna-Liisa
Published in Oncogene (01.12.2019)
Published in Oncogene (01.12.2019)
Get full text
Journal Article
Role of the Keap1–Nrf2 Pathway in Cancer
Leinonen, Hanna M., Kansanen, Emilia, Pölönen, Petri, Heinäniemi, Merja, Levonen, Anna-Liisa
Published in Advances in Cancer Research (2014)
Published in Advances in Cancer Research (2014)
Get full text
Book Chapter
Journal Article
Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production
Leinonen, Hanna M, Lepola, Saana, Lipponen, Eevi M, Heikura, Tommi, Koponen, Tiina, Parker, Nigel, Ylä-Herttuala, Seppo, Lesch, Hanna P
Published in Human gene therapy (01.03.2020)
Published in Human gene therapy (01.03.2020)
Get more information
Journal Article
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Kanninen, Katja, Heikkinen, Riikka, Malm, Tarja, Rolova, Taisia, Kuhmonen, Susanna, Leinonen, Hanna, Ylä-Herttuala, Seppo, Tanila, Heikki, Levonen, Anna-Liisa, Koistinaho, Milla, Koistinaho, Jari
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2009)
Get full text
Journal Article
Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism
Kansanen, Emilia, Bonacci, Gustavo, Schopfer, Francisco J., Kuosmanen, Suvi M., Tong, Kit I., Leinonen, Hanna, Woodcock, Steven R., Yamamoto, Masayuki, Carlberg, Carsten, Ylä-Herttuala, Seppo, Freeman, Bruce A., Levonen, Anna-Liisa
Published in The Journal of biological chemistry (22.04.2011)
Published in The Journal of biological chemistry (22.04.2011)
Get full text
Journal Article
Development of Large-Scale Downstream Processing for Lentiviral Vectors
Valkama, Anniina J., Oruetxebarria, Igor, Lipponen, Eevi M., Leinonen, Hanna M., Käyhty, Piia, Hynynen, Heidi, Turkki, Vesa, Malinen, Joonas, Miinalainen, Tuukka, Heikura, Tommi, Parker, Nigel R., Ylä-Herttuala, Seppo, Lesch, Hanna P.
Published in Molecular therapy. Methods & clinical development (12.06.2020)
Published in Molecular therapy. Methods & clinical development (12.06.2020)
Get full text
Journal Article
The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs
Kuosmanen, Suvi M, Viitala, Sari, Laitinen, Tuomo, Peräkylä, Mikael, Pölönen, Petri, Kansanen, Emilia, Leinonen, Hanna, Raju, Suresh, Wienecke-Baldacchino, Anke, Närvänen, Ale, Poso, Antti, Heinäniemi, Merja, Heikkinen, Sami, Levonen, Anna-Liisa
Published in Nucleic acids research (29.02.2016)
Published in Nucleic acids research (29.02.2016)
Get full text
Journal Article
Oxidative Stress-Regulated Lentiviral TK/GCV Gene Therapy for Lung Cancer Treatment
LEINONEN, Hanna M, RUOTSALAINEN, Anna-Kaisa, KAIKKONEN, Minna U, YLÄ-HERTTUALA, Seppo, LEVONEN, Anna-Liisa, MÄÄTTÄ, Ann-Marie, LAITINEN, Heidi M, KUOSMANEN, Suvi M, KANSANEN, Emilia, PIKKARAINEN, Jere T, LAPPALAINEN, Jari P, SAMARANAYAKE, Haritha, LESCH, Hanna P
Published in Cancer research (Chicago, Ill.) (01.12.2012)
Published in Cancer research (Chicago, Ill.) (01.12.2012)
Get full text
Journal Article
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1‐13C]pyruvate
Nivajärvi, Riikka, Olsson, Venla, Hyppönen, Viivi, Bowen, Sean, Leinonen, Hanna M., Lesch, Hanna P., Ardenkjær‐Larsen, Jan Henrik, Gröhn, Olli H.J., Ylä‐Herttuala, Seppo, Kettunen, Mikko I.
Published in NMR in biomedicine (01.04.2020)
Published in NMR in biomedicine (01.04.2020)
Get full text
Journal Article
Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells
Leinonen, Hanna M., Lipponen, Eevi M., Valkama, Anniina J., Hynynen, Heidi, Oruetxebarria, Igor, Turkki, Vesa, Olsson, Venla, Kurkipuro, Jere, Samaranayake, Haritha, Määttä, Ann-Marie, Parker, Nigel R., Ylä-Herttuala, Seppo, Lesch, Hanna P.
Published in Molecular therapy. Methods & clinical development (13.12.2019)
Published in Molecular therapy. Methods & clinical development (13.12.2019)
Get full text
Journal Article
Corrigendum: Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy
Eriksson, Reetta A E, Nieminen, Tiina, Galibert, Lionel, Peltola, Sanna K, Tikkanen, Petra, Käyhty, Piia, Leinonen, Hanna M, Oruetxebarria, Igor, Lepola, Saana, Valkama, Anniina J, Lipponen, Eevi M, Lesch, Hanna P, Ylä-Herttuala, Seppo, Airenne, Kari J
Published in Frontiers in medicine (03.03.2023)
Published in Frontiers in medicine (03.03.2023)
Get full text
Journal Article
Cytochrome P450 2A5 Constitutive Expression and Induction by Heavy Metals Is Dependent on Redox-Sensitive Transcription Factor Nrf2 in Liver
Lämsä, Virpi, Levonen, Anna-Liisa, Leinonen, Hanna, Ylä-Herttuala, Seppo, Yamamoto, Masayuki, Hakkola, Jukka
Published in Chemical research in toxicology (17.05.2010)
Published in Chemical research in toxicology (17.05.2010)
Get full text
Journal Article
Vascular Endothelial Growth Factor (VEGF)-D Stimulates VEGF-A, Stanniocalcin-1, and Neuropilin-2 and Has Potent Angiogenic Effects
Jauhiainen, Suvi, Häkkinen, Sanna-Kaisa, Toivanen, Pyry I, Heinonen, Suvi E, Jyrkkänen, Henna-Kaisa, Kansanen, Emilia, Leinonen, Hanna, Levonen, Anna-Liisa, Ylä-Herttuala, Seppo
Published in Arteriosclerosis, thrombosis, and vascular biology (01.07.2011)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.07.2011)
Get full text
Journal Article
Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy
Eriksson, Reetta A E, Nieminen, Tiina, Galibert, Lionel, Peltola, Sanna K, Tikkanen, Petra, Käyhty, Piia, Lesch, Hanna P, Ylä-Herttuala, Seppo, Airenne, Kari J
Published in Frontiers in medicine (13.12.2022)
Published in Frontiers in medicine (13.12.2022)
Get full text
Journal Article
Nrf2-dependent and -independent Responses to Nitro-fatty Acids in Human Endothelial Cells
Kansanen, Emilia, Jyrkkänen, Henna-Kaisa, Volger, Oscar L., Leinonen, Hanna, Kivelä, Annukka M., Häkkinen, Sanna-Kaisa, Woodcock, Steven R., Schopfer, Francisco J., Horrevoets, Anton J., Ylä-Herttuala, Seppo, Freeman, Bruce A., Levonen, Anna-Liisa
Published in The Journal of biological chemistry (27.11.2009)
Published in The Journal of biological chemistry (27.11.2009)
Get full text
Journal Article
Applications of the Keap1–Nrf2 system for gene and cell therapy
Kanninen, Katja M., Pomeshchik, Yuriy, Leinonen, Hanna, Malm, Tarja, Koistinaho, Jari, Levonen, Anna-Liisa
Published in Free radical biology & medicine (01.11.2015)
Published in Free radical biology & medicine (01.11.2015)
Get full text
Journal Article
PEI- LARGE SCALE PEI-MEDIATED PLASMID TRANSFECTION
MALINEN JOONAS, LESCH HANNA, VALKAMA ANNIINA, LEINONEN HANNA, LIPPONEN EEVI
Year of Publication 27.02.2024
Get full text
Year of Publication 27.02.2024
Patent
Optimizing lentiviral vector formulation conditions for efficient ex vivo transduction of primary human T cells in chimeric antigen receptor T-cell manufacturing
Luostarinen, Annu, Kailaanmäki, Anssi, Turkki, Vesa, Köylijärvi, Marjut, Käyhty, Piia, Leinonen, Hanna, Albers-Skirdenko, Vita, Lipponen, Eevi, Ylä-Herttuala, Seppo, Kaartinen, Tanja, Lesch, Hanna P., Kekarainen, Tuija
Published in Cytotherapy (Oxford, England) (01.09.2024)
Published in Cytotherapy (Oxford, England) (01.09.2024)
Get full text
Journal Article