Nilotinib in Imatinib-Resistant CML and Philadelphia Chromosome–Positive ALL
Kantarjian, Hagop, Giles, Francis, Wunderle, Lydia, Bhalla, Kapil, O'Brien, Susan, Wassmann, Barbara, Tanaka, Chiaki, Manley, Paul, Rae, Patricia, Mietlowski, William, Bochinski, Kathy, Hochhaus, Andreas, Griffin, James D, Hoelzer, Dieter, Albitar, Maher, Dugan, Margaret, Cortes, Jorge, Alland, Leila, Ottmann, Oliver G
Published in The New England journal of medicine (15.06.2006)
Published in The New England journal of medicine (15.06.2006)
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Safety of AFM11 in the treatment of patients with B-cell malignancies: findings from two phase 1 studies
Topp, Max, Dlugosz-Danecka, Monika, Skotnicki, Aleksander B, Salogub, Galina, Viardot, Andreas, Klein, Andreas K, Hess, Georg, Michel, Christian S, Grosicki, Sebastian, Gural, Alex, Schwarz, Sylvia E, Pietzko, Kerstin, Gärtner, Ulrike, Strassz, András, Alland, Leila, Mayer, Jiri
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AMN107, a Novel Aminopyrimidine Inhibitor of Bcr-Abl, Has In vitro Activity against Imatinib-Resistant Chronic Myeloid Leukemia
GOLEMOVIC, Mirna, VERSTOVSEK, Srdan, ARLINGHAUS, Ralph B, TONG SUN, KANTARJIAN, Hagop, BERAN, Miloslav, GILES, Francis, CORTES, Jorge, MANSHOURI, Taghi, MANLEY, Paul W, MESTAN, Jürgen, DUGAN, Margaret, ALLAND, Leila, GRIFFIN, James D
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Published in Clinical cancer research (01.07.2005)
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Randomized Phase III Trial of Pegylated Liposomal Doxorubicin Versus Vinorelbine or Mitomycin C Plus Vinblastine in Women With Taxane-Refractory Advanced Breast Cancer
KELLER, Alan M, MENNEL, Robert G, MELLARS, Lillian, ALLAND, Leila, TENDLER, Craig, GEORGOULIAS, Vassilis A, NABHOLTZ, Jean-Marc, ERAZO, Aura, LLUCH, Anna, VOGEL, Charles L, KAUFMANN, Manfred, VON MINCKWITZ, Gunther, HENDERSON, I. Craig
Published in Journal of clinical oncology (01.10.2004)
Published in Journal of clinical oncology (01.10.2004)
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Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein
DAVID, G, ALLAND, L, HONG, S.-H, WONG, C.-W, DEPINHO, R. A, DEJEAN, A
Published in Oncogene (14.05.1998)
Published in Oncogene (14.05.1998)
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AMN107, a novel aminopyrimidine inhibitor of p190 Bcr‐Abl activation and of in vitro proliferation of Philadelphia‐positive acute lymphoblastic leukemia cells
Verstovsek, Srdan, Golemovic, Mirna, Kantarjian, Hagop, Manshouri, Tashi, Estrov, Zeev, Manley, Paul, Sun, Tong, Arlinghaus, Ralph B., Alland, Leila, Dugan, Margaret, Cortes, Jorge, Giles, Francis, Beran, Miloslav
Published in Cancer (15.09.2005)
Published in Cancer (15.09.2005)
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Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex
Alland, Leila, David, Gregory, Shen-Li, Hong, Potes, Jason, Muhle, Rebecca, Lee, Hye-Chun, Hou, Harry, Chen, Ken, DePinho, Ronald A.
Published in Molecular and Cellular Biology (01.04.2002)
Published in Molecular and Cellular Biology (01.04.2002)
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A phase 1b study of AFM13 in combination with pembrolizumab in patients with relapsed or refractory Hodgkin lymphoma
Bartlett, Nancy L., Herrera, Alex F., Domingo-Domenech, Eva, Mehta, Amitkumar, Forero-Torres, Andres, Garcia-Sanz, Ramon, Armand, Philippe, Devata, Sumana, Izquierdo, Antonia Rodriguez, Lossos, Izidore S., Reeder, Craig, Sher, Taimur, Chen, Robert, Schwarz, Sylvia E., Alland, Leila, Strassz, Andras, Prier, Kim, Choe-Juliak, Cassandra, Ansell, Stephen M.
Published in Blood (19.11.2020)
Published in Blood (19.11.2020)
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Phase I analysis from the PYNNACLE phase I/II study of PC14586 in the subgroup of patients with advanced ovarian cancer harboring a TP53 Y220C mutation
Schram, Alison, Shapiro, Geoffrey, Thompson, John, Vandross, Andrae, Kummar, Shivaani, El-Khoueiry, Anthony, LeDuke, Kim, Fellous, Marc, Alland, Leila, Dumbrava, Ecaterina
Published in Gynecologic oncology (01.11.2024)
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Abstract 5806: Combination of the miniature drug conjugate PEN-866 with PARP inhibitors as a rational approach to overcoming limitations of PARP inhibitor monotherapy
Perino, Samantha, Quinn, James M., Callahan, Marrissa, Sharma, Gitanjali, White, Brian, Bilodeau, Mark, Alland, Leila, Whalen, Kerry, Wooster, Richard
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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First-in-human study of PC14586, a small molecule structural corrector of Y220C mutant p53, in patients with advanced solid tumors harboring a TP53 Y220C mutation
Dumbrava, Ecaterina Elena, Johnson, Melissa Lynne, Tolcher, Anthony W., Shapiro, Geoffrey, Thompson, John A., El-Khoueiry, Anthony B., Vandross, Andrae Lavon, Kummar, Shivaani, Parikh, Aparna Raj, Munster, Pamela N., Daly, Erika, De Leon, Laura, Khaddar, Megan, LeDuke, Kimberley, Robell, Kimberly, Sheehan, Lisa Iacono, St. Louis, Meagen, Wiebesiek, Amy, Alland, Leila, Schram, Alison M.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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COMBINATION THERAPIES COMPRISING TARGETED THERAPEUTICS
MARY SIMCOX, SAMANTHA PERINO, RICHARD WOOSTER, LEILA ALLAND, KERRY WHALEN, SUDHAKAR KADIYALA, MARK T BILODEAU
Year of Publication 28.07.2023
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Year of Publication 28.07.2023
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A Phase 1 Study Investigating AFM11 in Patients with Relapsed/Refractory B Cell Precursor Acute Lymphoblastic Leukemia: Preliminary Results
Salogub, Galina, Mayer, Jiri, Folber, Frantisek, Grosicki, Sebastian, Skotnicki, Aleksander B, Prochwicz, Anna, Myasnikov, Alexander, Gural, Alexander, Schoenborn-Kellenberger, Oliver, Brindley, Charlie, Knackmuss, Stefan, Schwarz, Sylvia, Schmich, Sandra, Choe-Juliak, Cassandra, Strassz, Andras, Alland, Leila, Doubek, Michael
Published in Blood (29.11.2018)
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First in human phase 1/2a study of PEN-221 somatostatin analog (SSA)-DM1 conjugate for patients (PTS) with advanced neuroendocrine tumor (NET) or small cell lung cancer (SCLC): Phase 1 results
Johnson, Melissa Lynne, Meyer, Tim, Halperin, Daniel M., Fojo, Antonio Tito, Cook, Natalie, Blaszkowsky, Lawrence Scott, Schlechter, Benjamin L., Yao, James C., Jemiai, Yannis, Kriksciukaite, Kristina, Jones, Marsha, Ezema, Nneamaka, Mei, Laura, Alland, Leila, Kulke, Matthew H.
Published in Journal of clinical oncology (20.05.2018)
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A Phase 1b Study Investigating the Combination of the Tetravalent Bispecific NK Cell Engager AFM13 and Pembrolizumab in Patients with Relapsed/Refractory Hodgkin Lymphoma after Brentuximab Vedotin Failure: Updated Safety and Efficacy Data
Bartlett, Nancy L., Chen, Robert W., Domingo-Domenech, Eva, Forero-Torres, Andres, Garcia-Sanz, Ramon, Armand, Philippe, Devata, Sumana, Rodriguez Izquierdo, Antonia, Lossos, Izidore S., Reeder, Craig B., Sher, Taimur, Choe-Juliak, Cassandra, Prier, Kim, Schwarz, Sylvia, Strassz, Andras, Alland, Leila, Ansell, Stephen M.
Published in Blood (29.11.2018)
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TSUN P AU YEUNG, CHRISTOPHER SEARS, RICHARD WOOSTER, BEATA SWERYDA-KRAWIEC, EUGENE ZHOROV, LEILA ALLAND, RAJESH R SHINDE, SUDHAKAR KADIYALA, MARK T BILODEAU
Year of Publication 03.08.2023
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Year of Publication 03.08.2023
Patent
Abstract LB_A25: Updated Phase 1 results from the PYNNACLE Phase 1/2 study of PC14586, a selective p53 reactivator, in patients with advanced solid tumors harboring a TP53 Y220C mutation
Schram, Alison M, Shapiro, Geoffrey I, Johnson, Melissa L, Tolcher, Anthony W., Thompson, John A, El-Khoueiry, Anthony B, Vandross, Andrae L, Kummar, Shivaani, Parikh, Aparna R, Shepard, Dale R, Garczarek, Ursula, LeDuke, Kim, Sheehan, Lisa, Fellous, Marc, Alland, Leila, Dumbrava, Ecaterina E
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Phase I Dose-Escalation Study of the Novel Antiandrogen BMS-641988 in Patients with Castration-Resistant Prostate Cancer
RATHKOPF, Dana, LIU, Glenn, FUNG, Nga Kit Eliza, CHENG, Shinta, JINPING GAN, GOTTARDIS, Marco, OBERMEIER, Mary T, REDDY, Jyotsna, ZHANG, Steven, VAKKALAGADDA, Blisse J, ALLAND, Leila, WILDING, George, CARDUCCI, Michael A, SCHER, Howard I, EISENBERGER, Mario A, ANAND, Aseem, MORRIS, Michael J, SLOVIN, Susan F, SASAKI, Yasutsuna, TAKAHASHI, Shunji, OZONO, Seiichiro
Published in Clinical cancer research (15.02.2011)
Published in Clinical cancer research (15.02.2011)
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Abstract B109: AZD5363, a catalytic pan-Akt inhibitor, in Akt1 E17K mutation positive advanced solid tumors
Hyman, David M., Smyth, Lillian, Bedard, Philippe L., Oza, Amit, Dean, Emma, Armstrong, Anne, Lima, Joao, Bando, Hideaki, Kabos, Peter, Perez-Fidalgo, J. Alejandro, Moore, Kathleen, Westin, Shannon N., You, Benoit, Chandarlapaty, Sarat, Alland, Leila, Ambrose, Helen, Foxley, Andrew, Lindemann, Justin, Pass, Martin, Rugman, Paul, Salim, Shaista, Schiavon, Gaia, Tamura, Kenji, Baselga, Jose, Banerji, Udai
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
Alland, Lelia, Muhle, Rebecca, Hou, Harry, Potes, Jason, Chin, Lynda, Schreiber-Agus, Nicole, DePinho, Ronald A
Published in Nature (London) (01.05.1997)
Published in Nature (London) (01.05.1997)
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