Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Dai, Wenhao, Zhang, Bing, Jiang, Xia-Ming, Su, Haixia, Li, Jian, Zhao, Yao, Xie, Xiong, Jin, Zhenming, Peng, Jingjing, Liu, Fengjiang, Li, Chunpu, Li, You, Bai, Fang, Wang, Haofeng, Cheng, Xi, Cen, Xiaobo, Hu, Shulei, Yang, Xiuna, Wang, Jiang, Liu, Xiang, Xiao, Gengfu, Jiang, Hualiang, Rao, Zihe, Zhang, Lei-Ke, Xu, Yechun, Yang, Haitao, Liu, Hong
Published in Science (19.06.2020)
Published in Science (19.06.2020)
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Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
Su, Hai-xia, Yao, Sheng, Zhao, Wen-feng, Li, Min-jun, Liu, Jia, Shang, Wei-juan, Xie, Hang, Ke, Chang-qiang, Hu, Hang-chen, Gao, Mei-na, Yu, Kun-qian, Liu, Hong, Shen, Jing-shan, Tang, Wei, Zhang, Lei-ke, Xiao, Geng-fu, Ni, Li, Wang, Dao-wen, Zuo, Jian-ping, Jiang, Hua-liang, Bai, Fang, Wu, Yan, Ye, Yang, Xu, Ye-chun
Published in Acta pharmacologica Sinica (01.09.2020)
Published in Acta pharmacologica Sinica (01.09.2020)
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SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO
Wu, Jing, Shi, Yuheng, Pan, Xiaoyan, Wu, Shuang, Hou, Ruixia, Zhang, Yong, Zhong, Tiansheng, Tang, Hao, Du, Wei, Wang, Luying, Wo, Jing, Mu, Jingfang, Qiu, Yang, Yang, Ke, Zhang, Lei-Ke, Ye, Bang-Ce, Qi, Nan
Published in Cell reports (Cambridge) (16.02.2021)
Published in Cell reports (Cambridge) (16.02.2021)
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SARS‐CoV‐2 envelope protein‐derived extracellular vesicles act as potential media for viral spillover
Li, Shuangqu, Bu, Jiwen, Pan, Xiaoyan, Li, Qiguang, Zuo, Xiaoli, Xiao, Gengfu, Du, Jiulin, Zhang, Lei‐Ke, Xia, Bingqing, Gao, Zhaobing
Published in Journal of medical virology (01.07.2024)
Published in Journal of medical virology (01.07.2024)
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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
Xia, Bingqing, Shen, Xurui, He, Yang, Pan, Xiaoyan, Liu, Feng-Liang, Wang, Yi, Yang, Feipu, Fang, Sui, Wu, Yan, Duan, Zilei, Zuo, Xiaoli, Xie, Zhuqing, Jiang, Xiangrui, Xu, Ling, Chi, Hao, Li, Shuangqu, Meng, Qian, Zhou, Hu, Zhou, Yubo, Cheng, Xi, Xin, Xiaoming, Jin, Lin, Zhang, Hai-Lin, Yu, Dan-Dan, Li, Ming-Hua, Feng, Xiao-Li, Chen, Jiekai, Jiang, Hualiang, Xiao, Gengfu, Zheng, Yong-Tang, Zhang, Lei-Ke, Shen, Jingshan, Li, Jia, Gao, Zhaobing
Published in Cell research (01.08.2021)
Published in Cell research (01.08.2021)
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Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients
Zhou, Li-Kun, Zhou, Zhen, Jiang, Xia-Ming, Zheng, Yishan, Chen, Xi, Fu, Zheng, Xiao, Gengfu, Zhang, Chen-Yu, Zhang, Lei-Ke, Yi, Yongxiang
Published in Cell discovery (05.08.2020)
Published in Cell discovery (05.08.2020)
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Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension
Zhang, Lei-Ke, Sun, Yuan, Zeng, Haolong, Wang, Qingxing, Jiang, Xiaming, Shang, Wei-Juan, Wu, Yan, Li, Shufen, Zhang, Yu-Lan, Hao, Zhao-Nian, Chen, Hongbo, Jin, Runming, Liu, Wei, Li, Hao, Peng, Ke, Xiao, Gengfu
Published in Cell discovery (22.12.2020)
Published in Cell discovery (22.12.2020)
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Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality
Li, Hao, Zhang, Lei-Ke, Li, Shu-Fen, Zhang, Shao-Fei, Wan, Wei-Wei, Zhang, Yu-Lan, Xin, Qi-Lin, Dai, Ke, Hu, Yuan-Yuan, Wang, Zhi-Bo, Zhu, Xiang-Tao, Fang, Yu-Jie, Cui, Ning, Zhang, Pan-He, Yuan, Chun, Lu, Qing-Bin, Bai, Jie-Ying, Deng, Fei, Xiao, Geng-Fu, Liu, Wei, Peng, Ke
Published in Cell research (01.09.2019)
Published in Cell research (01.09.2019)
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A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors
Ren, Peng-xuan, Shang, Wei-juan, Yin, Wan-chao, Ge, Huan, Wang, Lin, Zhang, Xiang-lei, Li, Bing-qian, Li, Hong-lin, Xu, Ye-chun, Xu, Eric H., Jiang, Hua-liang, Zhu, Li-li, Zhang, Lei-ke, Bai, Fang
Published in Acta pharmacologica Sinica (01.02.2022)
Published in Acta pharmacologica Sinica (01.02.2022)
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Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
Wang, Lin, Wu, Yan, Yao, Sheng, Ge, Huan, Zhu, Ya, Chen, Kun, Chen, Wen-zhang, Zhang, Yi, Zhu, Wei, Wang, Hong-yang, Guo, Yu, Ma, Pei-xiang, Ren, Peng-xuan, Zhang, Xiang-lei, Li, Hui-qiong, Ali, Mohammad A., Xu, Wen-qing, Jiang, Hua-liang, Zhang, Lei-ke, Zhu, Li-li, Ye, Yang, Shang, Wei-juan, Bai, Fang
Published in Acta pharmacologica Sinica (01.04.2022)
Published in Acta pharmacologica Sinica (01.04.2022)
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Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients
Wang, Yanbo, Zhu, Xiaoju, Jiang, Xia-Ming, Guo, Jingwei, Fu, Zheng, Zhou, Zhen, Yang, Ping, Guo, Hongyuan, Guo, Xu, Liang, Gaoli, Zeng, Ping, Xiao, Gengfu, Ma, Jizheng, Yin, Xin, Zhang, Lei-Ke, Yan, Chao, Zhang, Chen-Yu
Published in Signal transduction and targeted therapy (11.08.2021)
Published in Signal transduction and targeted therapy (11.08.2021)
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Longitudinal Profile of Laboratory Parameters and Their Application in the Prediction for Fatal Outcome Among Patients Infected With SARS-CoV-2: A Retrospective Cohort Study
Zeng, Hao-Long, Lu, Qing-Bin, Yang, Qing, Wang, Xu, Yue, Dao-Yuan, Zhang, Lei-Ke, Li, Hao, Liu, Wei, Li, Hui-Jun
Published in Clinical Infectious Diseases (16.02.2021)
Published in Clinical Infectious Diseases (16.02.2021)
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Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates
Wang, Yi, Fang, Sui, Wu, Yan, Cheng, Xi, Zhang, Lei-ke, Shen, Xu-rui, Li, Shuang-qu, Xu, Jian-rong, Shang, Wei-juan, Gao, Zhao-bing, Xia, Bing-qing
Published in Acta pharmacologica Sinica (01.04.2022)
Published in Acta pharmacologica Sinica (01.04.2022)
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Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus
Wang, Qingxing, Xin, Qilin, Shang, Weijuan, Wan, Weiwei, Xiao, Gengfu, Zhang, Lei-Ke
Published in Viruses (25.05.2021)
Published in Viruses (25.05.2021)
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Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2
Xia, Bingqing, Pan, Xiaoyan, Luo, Rong-Hua, Shen, Xurui, Li, Shuangqu, Wang, Yi, Zuo, Xiaoli, Wu, Yan, Guo, Yingqi, Xiao, Gengfu, Li, Qiguang, Long, Xin-Yan, He, Xiao-Yan, Zheng, Hong-Yi, Lu, Ying, Pang, Wei, Zheng, Yong-Tang, Li, Jia, Zhang, Lei-Ke, Gao, Zhaobing
Published in Cell discovery (06.01.2023)
Published in Cell discovery (06.01.2023)
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Regulation of the WNT-CTNNB1 signaling pathway by severe fever with thrombocytopenia syndrome virus in a cap-snatching manner
Jiang, Xia-Ming, Xin, Qi-Lin, Liu, Kai, Peng, Xue-Fang, Han, Shuo, Zhang, Ling-Yu, Liu, Wei, Xiao, Geng-Fu, Li, Hao, Zhang, Lei-Ke
Published in mBio (19.12.2023)
Published in mBio (19.12.2023)
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