1-(5-Carboxyindazol-1-yl)propan-2-ones as dual inhibitors of cytosolic phospholipase A 2 α and fatty acid amide hydrolase: bioisosteric replacement of the carboxylic acid moiety
Althaus, Jan, Hake, Theresa, Hanekamp, Walburga, Lehr, Matthias
Published in Journal of enzyme inhibition and medicinal chemistry (01.11.2016)
Published in Journal of enzyme inhibition and medicinal chemistry (01.11.2016)
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Convergent and enantioselective syntheses of cytosolic phospholipase A 2 α inhibiting N -(1-indazol-1-ylpropan-2-yl)carbamates
Sundermann, Tom, Arnsmann, Martina, Schwarzkopf, Julian, Hanekamp, Walburga, Lehr, Matthias
Published in Organic & biomolecular chemistry (21.06.2014)
Published in Organic & biomolecular chemistry (21.06.2014)
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Tu1780 - Regulated Expression of Phosphatidylserine-Specific Phospholipase A1 and Lysophosphatidylserine Receptors in Human Intestinal Inflammation
Tepasse, Phil-Robin, Heidemann, Jan, Bokemeyer, Arne, Cordes, Anna F., Brückner, Markus, Nowacki, Tobias M., Rijcken, Emile, Lehr, Matthias, Bettenworth, Dominik
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Published in Gastroenterology (New York, N.Y. 1943) (01.05.2018)
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1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A(2)alpha: Effect of Substituents in Position 3 of the Indole Scaffold on Inhibitory Potency, Metabolic Stability, Solubility, and Bioavailability
Bovens, Stefanie, Elfringhoff, Alwine Schulze, Kaptur, Martina, Reinhardt, Dirk, Schaefers, Michael, Lehr, Matthias
Published in Journal of medicinal chemistry (09.12.2010)
Published in Journal of medicinal chemistry (09.12.2010)
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Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones
Lehr, Matthias, Fabian, Jörg, Hanekamp, Walburga
Published in Biopharmaceutics & drug disposition (01.09.2015)
Published in Biopharmaceutics & drug disposition (01.09.2015)
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Convergent and enantioselective syntheses of cytosolic phospholipase A2α inhibiting N-(1-indazol-1-ylpropan-2-yl)carbamatesElectronic supplementary information (ESI) available. See DOI: 10.1039/c4ob00535j
Sundermann, Tom, Arnsmann, Martina, Schwarzkopf, Julian, Hanekamp, Walburga, Lehr, Matthias
Year of Publication 21.05.2014
Year of Publication 21.05.2014
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Synthesis, hydrolysis and stability of psilocin glucuronide
Martin, Rafaela, Schürenkamp, Jennifer, Pfeiffer, Heidi, Lehr, Matthias, Köhler, Helga
Published in Forensic science international (01.04.2014)
Published in Forensic science international (01.04.2014)
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Structure-activity relationship studies on 1-(5-carboxyindol-1-yl)-propan-2-one inhibitors of human cytosolic phospholipase A2α: variation of the activated ketone moiety
Kaptur, Martina, Elfringhoff, Alwine Schulze, Lehr, Matthias
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A2α: Effect of Substituents in Position 3 of the Indole Scaffold on Inhibitory Potency, Metabolic Stability, Solubility, and Bioavailability
Bovens, Stefanie, Schulze Elfringhoff, Alwine, Kaptur, Martina, Reinhardt, Dirk, Schäfers, Michael, Lehr, Matthias
Published in Journal of medicinal chemistry (09.12.2010)
Published in Journal of medicinal chemistry (09.12.2010)
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ω-Imidazolyl- and ω-Tetrazolylalkylcarbamates as Inhibitors of Fatty Acid Amide Hydrolase: Biological Activity and in vitro Metabolic Stability
Terwege, Tobias, Hanekamp, Walburga, Garzinsky, David, König, Simone, Koch, Oliver, Lehr, Matthias
Published in ChemMedChem (17.02.2016)
Published in ChemMedChem (17.02.2016)
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omega-Imidazolyl- and omega-Tetrazolylalkylcarbamates as Inhibitors of Fatty Acid Amide Hydrolase: Biological Activity and invitro Metabolic Stability
Terwege, Tobias, Hanekamp, Walburga, Garzinsky, David, Koenig, Simone, Koch, Oliver, Lehr, Matthias
Published in ChemMedChem (17.02.2016)
Published in ChemMedChem (17.02.2016)
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1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2α : Synthesis, biological activity, metabolic stability, and solubility
FRITSCHE, Alexandra, ELFRINGHOFF, Alwine Schulze, FABIAN, Jörg, LEHR, Matthias
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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1-(5-Carboxy-and 5 -carbamoylindol -1 -yl )propan -2 -ones as inhibitors of human cytosolic phospholipase A2α : Bioisosteric replacement of the carboxylic acid and carboxamide moiety
HESS, Mark, SCHULZE ELFRINGHOFF, Alwine, LEHR, Matthias
Published in Bioorganic & medicinal chemistry (15.04.2007)
Published in Bioorganic & medicinal chemistry (15.04.2007)
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Jubiläum 25 Jahre Tag der Zahngesundheit: VfZ-Sonderaktion: Coole „Zahnputzdrachen
Published in Oralprophylaxe & Kinderzahnheilkunde
(2015)
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