Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)
Scott, William J., Hentemann, Martin F., Rowley, R. Bruce, Bull, Cathy O., Jenkins, Susan, Bullion, Ann M., Johnson, Jeffrey, Redman, Anikó, Robbins, Arthur H., Esler, William, Fracasso, R. Paul, Garrison, Timothy, Hamilton, Mark, Michels, Martin, Wood, Jill E., Wilkie, Dean P., Xiao, Hong, Levy, Joan, Stasik, Enrico, Liu, Ningshu, Schaefer, Martina, Brands, Michael, Lefranc, Julien
Published in ChemMedChem (19.07.2016)
Published in ChemMedChem (19.07.2016)
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Journal Article
Amines Bearing Tertiary Substituents by Tandem Enantioselective Carbolithiation–Rearrangement of Vinylureas
Tait, Michael, Donnard, Morgan, Minassi, Alberto, Lefranc, Julien, Bechi, Beatrice, Carbone, Giorgio, O’Brien, Peter, Clayden, Jonathan
Published in Organic letters (04.01.2013)
Published in Organic letters (04.01.2013)
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Journal Article
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models
Lemos, Clara, Schulze, Volker K., Baumgart, Simon J., Nevedomskaya, Ekaterina, Heinrich, Tobias, Lefranc, Julien, Bader, Benjamin, Christ, Clara D., Briem, Hans, Kuhnke, Lara P., Holton, Simon J., Bömer, Ulf, Lienau, Philip, von Nussbaum, Franz, Nising, Carl F., Bauser, Marcus, Hägebarth, Andrea, Mumberg, Dominik, Haendler, Bernard
Published in Cellular oncology (Dordrecht) (01.06.2021)
Published in Cellular oncology (Dordrecht) (01.06.2021)
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Journal Article
Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy
Kober, Christina, Roewe, Julian, Schmees, Norbert, Roese, Lars, Roehn, Ulrike, Bader, Benjamin, Stoeckigt, Detlef, Prinz, Florian, Gorjánácz, Mátyás, Roider, Helge Gottfried, Olesch, Catherine, Leder, Gabriele, Irlbacher, Horst, Lesche, Ralf, Lefranc, Julien, Oezcan-Wahlbrink, Mine, Batra, Ankita Sati, Elmadany, Nirmeen, Carretero, Rafael, Sahm, Katharina, Oezen, Iris, Cichon, Frederik, Baumann, Daniel, Sadik, Ahmed, Opitz, Christiane A, Weinmann, Hilmar, Hartung, Ingo V, Kreft, Bertolt, Offringa, Rienk, Platten, Michael, Gutcher, Ilona
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates
Lefranc, Julien, Minassi, Alberto, Clayden, Jonathan
Published in Beilstein journal of organic chemistry (28.03.2013)
Published in Beilstein journal of organic chemistry (28.03.2013)
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Journal Article
Synthetic approaches towards alkaloids bearing α-tertiary amines
Hager, Anastasia, Vrielink, Nina, Hager, Dominik, Lefranc, Julien, Trauner, Dirk
Published in Natural product reports (01.03.2016)
Published in Natural product reports (01.03.2016)
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Journal Article
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models
Wengner, Antje M, Siemeister, Gerhard, Lücking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Bömer, Ulf, Moosmayer, Dieter, Eberspächer, Uwe, Golfier, Sven, Schatz, Christoph A, Baumgart, Simon J, Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik
Published in Molecular cancer therapeutics (01.01.2020)
Published in Molecular cancer therapeutics (01.01.2020)
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Journal Article
Nickel‐Catalyzed N‐Arylation of NH‐Sulfoximines with Aryl Halides via Paired Electrolysis
Liu, Dong, Liu, Zhao‐Ran, Ma, Cong, Jiao, Ke‐Jin, Sun, Bing, Wei, Lei, Lefranc, Julien, Herbert, Simon, Mei, Tian‐Sheng
Published in Angewandte Chemie International Edition (19.04.2021)
Published in Angewandte Chemie International Edition (19.04.2021)
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Journal Article
Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models
Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor
Lefranc, Julien, Schulze, Volker Klaus, Hillig, Roman Christian, Briem, Hans, Prinz, Florian, Mengel, Anne, Heinrich, Tobias, Balint, Jozsef, Rengachari, Srinivasan, Irlbacher, Horst, Stöckigt, Detlef, Bömer, Ulf, Bader, Benjamin, Gradl, Stefan Nikolaus, Nising, Carl Friedrich, von Nussbaum, Franz, Mumberg, Dominik, Panne, Daniel, Wengner, Antje Margret
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Journal Article
Tandem β-Alkylation−α-Arylation of Amines by Carbolithiation and Rearrangement of N-Carbamoyl Enamines (Vinyl Ureas)
Clayden, Jonathan, Donnard, Morgan, Lefranc, Julien, Minassi, Alberto, Tetlow, Daniel J
Published in Journal of the American Chemical Society (19.05.2010)
Published in Journal of the American Chemical Society (19.05.2010)
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Journal Article
Back in Person: Frontiers in Medicinal Chemistry 2023
Gehringer, Matthias, Pape, Felix, Méndez, María, Barbie, Philipp, Unzue Lopez, Andrea, Lefranc, Julien, Klingler, Franca-Maria, Hessler, Gerhard, Langer, Thierry, Diamanti, Eleonora, Schiedel, Matthias
Published in ChemMedChem (04.10.2023)
Published in ChemMedChem (04.10.2023)
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Journal Article
Abstract 321: Synergistic activity of the ATR inhibitor BAY 1895344 in combination with DNA damage inducing and DNA repair compromising therapies in preclinical tumor models
Wengner, Antje Margret, Siemeister, Gerhard, Luecking, Ulrich, Lefranc, Julien, Meyer, Kirstin, Lagkadinou, Eleni, Haendler, Bernard, Lejeune, Pascale, Mumberg, Dominik
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 838: Synergistic in vivo activity of the ATR inhibitor BAY 1895344 in combination with the targeted alpha therapy radium-223 dichloride in a preclinical tumor model mimicking bone metastatic castration-resistant prostate cancer (mCRPC)
Wengner, Antje Margret, Siemeister, Gerhard, Luecking, Ulrich, Lefranc, Julien, Scholz, Arne, Suominen, Mari, Meyer, Kirstin, Lagkadinou, Eleni, Mumberg, Dominik
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Intramolecular Vinylation of Secondary and Tertiary Organolithiums
Lefranc, Julien, Fournier, Anne M, Mingat, Gaëlle, Herbert, Simon, Marcelli, Tommaso, Clayden, Jonathan
Published in Journal of the American Chemical Society (02.05.2012)
Published in Journal of the American Chemical Society (02.05.2012)
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Journal Article
Frontiers in Medicinal Chemistry 2022 Goes Virtual
Diamanti, Eleonora, Méndez, María, Ross, Tatjana, Kuttruff, Christian A., Lefranc, Julien, Klingler, Franca‐Maria, Nussbaum, Franz, Jung, Manfred, Gehringer, Matthias
Published in ChemMedChem (04.11.2022)
Published in ChemMedChem (04.11.2022)
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Journal Article
Abstract 5873: BAY-3827, a selective inhibitor of AMPK for the evaluation of the role of AMPK in Myc-dependent tumors
Lemos, Clara, Schulze, Volker K., Bader, Benjamin, Christ, Clara D., Briem, Hans, Politz, Oliver, Prinz, Florian, Holton, Simon, Heinrich, Tobias, Lefranc, Julien, Lienau, Philip, Scholz, Arne, Nussbaum, Franz von, Nising, Carl Friedrich, Mumberg, Dominik, Bauser, Marcus, Hägebarth, Andrea
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 836: ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models
Wengner, Antje Margret, Siemeister, Gerhard, Luecking, Ulrich, Lefranc, Julien, Lienau, Philip, Deeg, Gesa, Lagkadinou, Eleni, Liu, Li, Golfier, Sven, Schatz, Christoph, Scholz, Arne, Nussbaum, Franz von, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 160: High target binding affinity with long lasting cellular target engagement and high dose intermittent schedule of PI3K inhibitor copanlisib contribute to the potent anti-tumor activity and good safety profile
Fernández-Montalván, Amaury E., Georgi, Victoria, Vasta, James, Glaeske, Sarah, Puetter, Vera, Robers, Matthew B., Moenning, Ursula, Sturz, Andrea, Lefranc, Julien, Ziegelbauer, Karl, Brands, Michael, Stegmann, Christian, Scott, William J., Liu, Ningshu
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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