Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
Ladds, Marcus J. G.W., Popova, Gergana, Pastor-Fernández, Andrés, Kannan, Srinivasaraghavan, van Leeuwen, Ingeborg M.M., Håkansson, Maria, Walse, Björn, Tholander, Fredrik, Bhatia, Ravi, Verma, Chandra S., Lane, David P., Laín, Sonia
Published in The Journal of biological chemistry (25.12.2020)
Published in The Journal of biological chemistry (25.12.2020)
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Journal Article
Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase
Costeira-Paulo, Joana, Gault, Joseph, Popova, Gergana, Ladds, Marcus J.G.W., van Leeuwen, Ingeborg M.M., Sarr, Médoune, Olsson, Anders, Lane, David P., Laín, Sonia, Marklund, Erik G., Landreh, Michael
Published in Cell chemical biology (15.03.2018)
Published in Cell chemical biology (15.03.2018)
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Journal Article
Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2
van Leeuwen, Ingeborg M M, Higgins, Maureen, Campbell, Johanna, McCarthy, Anna R, Sachweh, Marijke C C, Navarro, Ana Marín, Laín, Sonia
Published in Molecular cancer therapeutics (01.04.2013)
Published in Molecular cancer therapeutics (01.04.2013)
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Journal Article
Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner
McCarthy, Anna R, Sachweh, Marijke C C, Higgins, Maureen, Campbell, Johanna, Drummond, Catherine J, van Leeuwen, Ingeborg M M, Pirrie, Lisa, Ladds, Marcus J G W, Westwood, Nicholas J, Laín, Sonia
Published in Molecular cancer therapeutics (01.04.2013)
Published in Molecular cancer therapeutics (01.04.2013)
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Journal Article
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
Ladds, Marcus J G W, Pastor-Fernández, Andrés, Popova, Gergana, van Leeuwen, Ingeborg M M, Eng, Kai Er, Drummond, Catherine J, Johansson, Lars, Svensson, Richard, Westwood, Nicholas J, McCarthy, Anna R, Tholander, Fredrik, Popa, Mihaela, Lane, David P, McCormack, Emmet, McInerney, Gerald M, Bhatia, Ravi, Laín, Sonia
Published in PloS one (23.04.2018)
Published in PloS one (23.04.2018)
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Journal Article
Mechanism-specific signatures for small-molecule p53 activators
van Leeuwen, Ingeborg M.M., Higgins, Maureen, Campbell, Johanna, Brown, Christopher J., McCarthy, Anna R., Pirrie, Lisa, Westwood, Nicholas J., Laín, Sonia
Published in Cell cycle (Georgetown, Tex.) (15.05.2011)
Published in Cell cycle (Georgetown, Tex.) (15.05.2011)
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Journal Article
Towards a multiscale model of colorectal cancer
van Leeuwen, Ingeborg M M, Edwards, Carina M, Ilyas, Mohammad, Byrne, Helen M
Published in World journal of gastroenterology : WJG (07.03.2007)
Published in World journal of gastroenterology : WJG (07.03.2007)
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Journal Article
Correction: Modulation of p53 C-Terminal Acetylation by Mdm2, p14ARF, and Cytoplasmic SirT2
van Leeuwen, Ingeborg M.M., Higgins, Maureen, Campbell, Johanna, McCarthy, Anna R., Sachweh, Marijke C.C., Navarro, Ana Marín, Laín, Sonia
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Modelling microbial adaptation to changing availability of substrates
Brandt, Bernd W., Kelpin, Fleur D.L., van Leeuwen, Ingeborg M.M., Kooijman, Sebastiaan A.L.M.
Published in Water research (Oxford) (01.02.2004)
Published in Water research (Oxford) (01.02.2004)
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Journal Article
Chaste: A test-driven approach to software development for biological modelling
Pitt-Francis, Joe, Pathmanathan, Pras, Bernabeu, Miguel O., Bordas, Rafel, Cooper, Jonathan, Fletcher, Alexander G., Mirams, Gary R., Murray, Philip, Osborne, James M., Walter, Alex, Chapman, S. Jon, Garny, Alan, van Leeuwen, Ingeborg M.M., Maini, Philip K., Rodríguez, Blanca, Waters, Sarah L., Whiteley, Jonathan P., Byrne, Helen M., Gavaghan, David J.
Published in Computer physics communications (01.12.2009)
Published in Computer physics communications (01.12.2009)
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Journal Article
From exposure to effect: a comparison of modeling approaches to chemical carcinogenesis
van Leeuwen, Ingeborg M.M., Zonneveld, Cor
Published in Mutation Research-Reviews in Mutation Research (01.10.2001)
Published in Mutation Research-Reviews in Mutation Research (01.10.2001)
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Book Review
Journal Article
In Vitro Inhibition of Thyroid Hormone Sulfation by Hydroxylated Metabolites of Halogenated Aromatic Hydrocarbons
Schuur, A. Gerlienke, Legger, Fransje F, van Meeteren, Marieke E, Moonen, Mariëlle J. H, van Leeuwen-Bol, Ingeborg, Bergman, Åke, Visser, Theo J, Brouwer, Abraham
Published in Chemical research in toxicology (01.09.1998)
Published in Chemical research in toxicology (01.09.1998)
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Journal Article