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Kemp, J. A., Foster, A. C., Lesson, P. D., Priestley, T., Tridgett, R., Iversen, L. L., Woodruff, G. N.
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.1988)
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.1988)
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Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists
Rowley, Michael, Kulagowski, Janusz J, Watt, Alan P, Rathbone, Denise, Stevenson, Graeme I, Carling, Robert W, Baker, Raymond, Marshall, George R, Kemp, John A, Foster, Alan C, Grimwood, Sarah, Hargreaves, Richard, Hurley, Catherine, Saywell, Kay L, Tricklebank, Mark D, Leeson, Paul D
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Published in Journal of medicinal chemistry (05.12.1997)
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5-(4-Chlorophenyl)-4-methyl-3-(1-(2- phenylethyl)piperidin-4-yl)isoxazole: A Potent, Selective Antagonist at Human Cloned Dopamine D4 Receptors
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Published in Journal of medicinal chemistry (10.05.1996)
Published in Journal of medicinal chemistry (10.05.1996)
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Enantiomers of HA-966 (3-Amino-1-Hydroxypyrrolid-2-One) Exhibit Distinct Central Nervous System Effects: (+)-HA-966 is a Selective Glycine/N- Methyl-D-Aspartate Receptor Antagonist, But (-)-HA-966 is a Potent γ-Butyrolactone-Like Sedative
Singh, L., Donald, A. E., Foster, A. C., Hutson, P. H., Iversen, L. L., Iversen, S. D., Kemp, J. A., Leeson, P. D., Marshall, G. R., Oles, R. J., Priestley, T., Thorn, L., Tricklebank, M. D., Vass, C. A., Williams, B. J.
Published in Proceedings of the National Academy of Sciences - PNAS (01.01.1990)
Published in Proceedings of the National Academy of Sciences - PNAS (01.01.1990)
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The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents
Bristow, L J, Flatman, K L, Hutson, P H, Kulagowski, J J, Leeson, P D, Young, L, Tricklebank, M D
Published in The Journal of pharmacology and experimental therapeutics (01.05.1996)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1996)
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4-Substituted-3-phenylquinolin-2(1H)-ones: Acidic and Nonacidic Glycine Site N-Methyl-d-aspartate Antagonists with in Vivo Activity
Carling, Robert W, Leeson, Paul D, Moore, Kevin W, Moyes, Christopher R, Duncton, Matthew, Hudson, Martin L, Baker, Raymond, Foster, Alan C, Grimwood, Sarah, Kemp, John A, Marshall, George R, Tricklebank, Mark D, Saywell, Kay L
Published in Journal of medicinal chemistry (28.02.1997)
Published in Journal of medicinal chemistry (28.02.1997)
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Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain
FOSTER, A. C, KEMP, J. A, LEESON, P. D, GRIMWOOD, S, DONALD, A. E, MARSHALL, G. R, PRIESTLEY, T, SMITH, J. D, CARLING, R. W
Published in Molecular pharmacology (01.05.1992)
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Published in Molecular pharmacology (01.05.1992)
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2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the NMDA receptor
CARLING, R. W, LEESON, P. D, MOSELY, A. M, BAKER, R, FOSTER, A. C, GRIWMOOD, S, KEMP, J. A, MARSHALL, G. R
Published in Journal of medicinal chemistry (29.05.1992)
Published in Journal of medicinal chemistry (29.05.1992)
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3-Nitro-3,4-dihydro-2(1H)quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
CARLING, R. W, LEESON, P. D, GRIMWOOD, S, KEMP, J. A, MARSHALL, G. R, TRICKLEBANK, M. D, SAYWELL, K. L, MOORE, K. W, SMITH, J. D, MOYES, C. R, MAWER, I. M, THOMAS, S, CHAN, T, BAKER, R, FOSTER, A. C
Published in Journal of medicinal chemistry (29.10.1993)
Published in Journal of medicinal chemistry (29.10.1993)
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The anticonvulsant and behavioural profile of L‐687,414, a partial agonist acting at the glycine modulatory site on the N‐methyl‐D‐aspartate (NMDA) receptor complex
Tricklebank, M.D., Bristow, L.J., Hutson, P.H., Leeson, P.D., Rowley, M., Saywell, K., Singh, L., Tattersall, F.D., Thorn, L., Williams, B.J.
Published in British journal of pharmacology (01.11.1994)
Published in British journal of pharmacology (01.11.1994)
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Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex
Bristow, L J, Hutson, P H, Kulagowski, J J, Leeson, P D, Matheson, S, Murray, F, Rathbone, D, Saywell, K L, Thorn, L, Watt, A P, Tricklebank, M D
Published in The Journal of pharmacology and experimental therapeutics (01.11.1996)
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Published in The Journal of pharmacology and experimental therapeutics (01.11.1996)
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Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor
Leeson, Paul D, Baker, Raymond, Carling, Robert W, Curtis, Neil R, Moore, Kevin W, Williams, Brian J, Foster, Alan C, Donald, Angus E, Kemp, John A, Marshall, George R
Published in Journal of medicinal chemistry (01.04.1991)
Published in Journal of medicinal chemistry (01.04.1991)
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4-Heterocyclylpiperidines as Selective High-Affinity Ligands at the Human Dopamine D4 Receptor
Rowley, Michael, Collins, Ian, Broughton, Howard B, Davey, William B, Baker, Raymond, Emms, Frances, Marwood, Rosemarie, Patel, Shil, Patel, Smita, Ragan, C. Ian, Freedman, Stephen B, Ball, Richard, Leeson, Paul D
Published in Journal of medicinal chemistry (18.07.1997)
Published in Journal of medicinal chemistry (18.07.1997)
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4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor
Leeson, Paul D, Carling, Robert W, Moore, Kevin W, Moseley, Angela M, Smith, Julian D, Stevenson, Graeme, Chan, Tony, Baker, Raymond, Foster, Alan C
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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A thyromimetic that decreases plasma cholesterol levels without increasing cardiac activity
Underwood, A H, Emmett, J C, Ellis, D, Flynn, S B, Leeson, P D, Benson, G M, Novelli, R, Pearce, N J, Shah, V P
Published in Nature (London) (04.12.1986)
Published in Nature (London) (04.12.1986)
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Is There a Difference between Leads and Drugs? A Historical Perspective
Oprea, Tudor I, Davis, Andrew M, Teague, Simon J, Leeson, Paul D
Published in Journal of Chemical Information and Computer Sciences (01.09.2001)
Published in Journal of Chemical Information and Computer Sciences (01.09.2001)
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The Design of Leadlike Combinatorial Libraries
Teague, Simon J., Davis, Andrew M., Leeson, Paul D., Oprea, Tudor
Published in Angewandte Chemie (International ed.) (16.12.1999)
Published in Angewandte Chemie (International ed.) (16.12.1999)
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