Functional Consequences of Cysteine Modification in the Ligand Binding Sites of Peroxisome Proliferator Activated Receptors by GW9662
Leesnitzer, Lisa M, Parks, Derek J, Bledsoe, Randy K, Cobb, Jeff E, Collins, Jon L, Consler, Thomas G, Davis, Roderick G, Hull-Ryde, Emily A, Lenhard, James M, Patel, Lisa, Plunket, Kelli D, Shenk, Jennifer L, Stimmel, Julie B, Therapontos, Christina, Willson, Timothy M, Blanchard, Steven G
Published in Biochemistry (Easton) (28.05.2002)
Published in Biochemistry (Easton) (28.05.2002)
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Journal Article
The 15-Lipoxygenase-1 Product 13-S-Hydroxyoctadecadienoic Acid Down-Regulates PPAR-δ to Induce Apoptosis in Colorectal Cancer Cells
Shureiqi, Imad, Jiang, Wei, Zuo, Xiangsheng, Wu, Yuanqing, Stimmel, Julie B., Leesnitzer, Lisa M., Morris, Jeffrey S., Fan, Hui-Zhen, Fischer, Susan M., Lippman, Scott M.
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2003)
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Journal Article
A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity
Rocchi, Stéphane, Picard, Frédéric, Vamecq, Joseph, Gelman, Laurent, Potier, Noelle, Zeyer, Denis, Dubuquoy, Laurent, Bac, Pierre, Champy, Marie-France, Plunket, Kelli D., Leesnitzer, Lisa M., Blanchard, Steven G., Desreumaux, Pierre, Moras, Dino, Renaud, Jean-Paul, Auwerx, Johan
Published in Molecular cell (01.10.2001)
Published in Molecular cell (01.10.2001)
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Journal Article
Oxidative metabolism of linoleic acid modulates PPAR-beta delta suppression of PPAR-gamma activity
ZUO, X, WU, Y, MORRIS, J. S, STIMMEL, J. B, LEESNITZER, L. M, FISCHER, S. M, LIPPMAN, S. M, SHUREIQI, I
Published in Oncogene (23.02.2006)
Published in Oncogene (23.02.2006)
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Journal Article
The Novel Synthetic Triterpenoid, CDDO-Imidazolide, Inhibits Inflammatory Response and Tumor Growth in Vivo
PLACE, Andrew E, NANJOO SUH, ROSEN, Evan, SPORN, Michael B, WILLIAMS, Charlotte R, RISINGSONG, Renee, HONDA, Tadashi, HONDA, Yukiko, GRIBBLE, Gordon W, LEESNITZER, Lisa M, STIMMEL, Julie B, WILLSON, Timothy M
Published in Clinical cancer research (01.07.2003)
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Published in Clinical cancer research (01.07.2003)
Journal Article
N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents
Henke, Brad R, Blanchard, Steven G, Brackeen, Marcus F, Brown, Kathleen K, Cobb, Jeff E, Collins, Jon L, Harrington, W. Wallace, Hashim, Mir A, Hull-Ryde, Emily A, Kaldor, Istvan, Kliewer, Steven A, Lake, Debra H, Leesnitzer, Lisa M, Lehmann, Jürgen M, Lenhard, James M, Orband-Miller, Lisa A, Miller, John F, Mook, Robert A, Noble, Stewart A, Oliver, William, Parks, Derek J, Plunket, Kelli D, Szewczyk, Jerzy R, Willson, Timothy M
Published in Journal of medicinal chemistry (03.12.1998)
Published in Journal of medicinal chemistry (03.12.1998)
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Journal Article
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors
Thuillier, Philippe, Brash, Alan R, Kehrer, James P, Stimmel, Julie B, Leesnitzer, Lisa M, Yang, Peiying, Newman, Robert A, Fischer, Susan M
Published in Biochemical journal (15.09.2002)
Published in Biochemical journal (15.09.2002)
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Journal Article
Conjugated linoleic acid is an activator and ligand for peroxisome proliferator-activated receptor-gamma (PPARγ)
Belury, Martha A, Moya-Camarena, Silvia Y, Lu, Ming, Shi, Lingling, Leesnitzer, Lisa M, Blanchard, Steven G
Published in Nutrition research (New York, N.Y.) (2002)
Published in Nutrition research (New York, N.Y.) (2002)
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Journal Article
N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 2. Structure−Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety
Collins, Jon L, Blanchard, Steven G, Boswell, G. Evan, Charifson, Paul S, Cobb, Jeff E, Henke, Brad R, Hull-Ryde, Emily A, Kazmierski, Wieslaw M, Lake, Debra H, Leesnitzer, Lisa M, Lehmann, Jürgen, Lenhard, James M, Orband-Miller, Lisa A, Gray-Nunez, Yolanda, Parks, Derek J, Plunkett, Kelli D, Tong, Wei-Qin
Published in Journal of medicinal chemistry (03.12.1998)
Published in Journal of medicinal chemistry (03.12.1998)
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Journal Article
Subtype Specific Effects of Peroxisome Proliferator-Activated Receptor Ligands on Corepressor Affinity
Stanley, Thomas B, Leesnitzer, Lisa M, Montana, Valerie G, Galardi, Cristin M, Lambert, Millard H, Holt, Jason A, Xu, H. Eric, Moore, Linda B, Blanchard, Steven G, Stimmel, Julie B
Published in Biochemistry (Easton) (12.08.2003)
Published in Biochemistry (Easton) (12.08.2003)
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Journal Article
Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activity on PPARα, PPARγ, and PPARδ
Liu, Kevin G, Smith, Jennifer S, Ayscue, Andrea H, Henke, Brad R, Lambert, Millard H, Leesnitzer, Lisa M, Plunket, Kelli D, Willson, Timothy M, Sternbach, Daniel D
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Journal Article
Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis
Liu, Kevin G, Lambert, Millard H, Leesnitzer, Lisa M, Oliver, William, Ott, Ronda J, Plunket, Kelli D, Stuart, Ludwig W, Brown, Peter J, Willson, Timothy M, Sternbach, Daniel D
Published in Bioorganic & medicinal chemistry letters (19.11.2001)
Published in Bioorganic & medicinal chemistry letters (19.11.2001)
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Journal Article
Synthesis and biological activity of l-tyrosine-based PPARγ agonists with reduced molecular weight
Liu, Kevin G., Lambert, Millard H., Ayscue, Andrea H., Henke, Brad R., Leesnitzer, Lisa M., Oliver, Jr, William R., Plunket, Kelli D., Xu, H.Eric, Sternbach, Daniel D., Willson, Timothy M.
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
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Journal Article
Helix 1/8 Interactions Influence the Activity of Nuclear Receptor Ligand-Binding Domains
Holt, Jason A, Consler, Thomas G, Williams, Shawn P, Ayscue, Andrea H, Leesnitzer, Lisa M, Wisely, G. Bruce, Billin, Andrew N
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2003)
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2003)
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Journal Article
Synthesis and biological activity of a novel series of indole-derived PPARγ agonists
Henke, Brad R., Adkison, Kimberley K., Blanchard, Steven G., Leesnitzer, Lisa M., Mook, Robert A., Plunket, Kelli D., Ray, John A., Roberson, Claudia, Unwalla, Rayomand, Willson, Timothy M.
Published in Bioorganic & medicinal chemistry letters (06.12.1999)
Published in Bioorganic & medicinal chemistry letters (06.12.1999)
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Journal Article
Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta
Liu, K G, Smith, J S, Ayscue, A H, Henke, B R, Lambert, M H, Leesnitzer, L M, Plunket, K D, Willson, T M, Sternbach, D D
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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