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ATG2 transports lipids to promote autophagosome biogenesis
Valverde, Diana P., Yu, Shenliang, Boggavarapu, Venkata, Kumar, Nikit, Lees, Joshua A., Walz, Thomas, Reinisch, Karin M., Melia, Thomas J.
Published in The Journal of cell biology (03.06.2019)
Published in The Journal of cell biology (03.06.2019)
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VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites
Kumar, Nikit, Leonzino, Marianna, Hancock-Cerutti, William, Horenkamp, Florian A., Li, PeiQi, Lees, Joshua A., Wheeler, Heather, Reinisch, Karin M., De Camilli, Pietro
Published in The Journal of cell biology (01.10.2018)
Published in The Journal of cell biology (01.10.2018)
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Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion
Lees, Joshua A., Messa, Mirko, Sun, Elizabeth Wen, Wheeler, Heather, Torta, Federico, Wenk, Markus R., De Camilli, Pietro, Reinisch, Karin M.
Published in Science (American Association for the Advancement of Science) (17.02.2017)
Published in Science (American Association for the Advancement of Science) (17.02.2017)
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An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism
Lees, Joshua A., Dias, João M., Rajamohan, Francis, Fortin, Jean-Philippe, O’Connor, Rebecca, Kong, Jimmy X., Hughes, Emily A. G., Fisher, Ethan L., Tuttle, Jamison B., Lovett, Gabrielle, Kormos, Bethany L., Unwalla, Rayomand J., Zhang, Lei, Dechert Schmitt, Anne-Marie, Zhou, Dahui, Moran, Michael, Stevens, Kimberly A., Fennell, Kimberly F., Varghese, Alison E., Maxwell, Andrew, Cote, Emmaline E., Zhang, Yuan, Han, Seungil
Published in Nature communications (23.09.2023)
Published in Nature communications (23.09.2023)
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Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine
Silmon de Monerri, Natalie C., Che, Ye, Lees, Joshua A., Jasti, Jayasankar, Wu, Huixian, Griffor, Matthew C., Kodali, Srinivas, Hawkins, Julio Cesar, Lypowy, Jacqueline, Ponce, Christopher, Curley, Kieran, Esadze, Alexandre, Carcamo, Juan, McLellan, Thomas, Keeney, David, Illenberger, Arthur, Matsuka, Yury V., Shanker, Suman, Chorro, Laurent, Gribenko, Alexey V., Han, Seungil, Anderson, Annaliesa S., Donald, Robert G. K.
Published in PLoS pathogens (19.02.2025)
Published in PLoS pathogens (19.02.2025)
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Molecular organization of the COG vesicle tethering complex
Lees, Joshua A, Yip, Calvin K, Walz, Thomas, Hughson, Frederick M
Published in Nature structural & molecular biology (01.11.2010)
Published in Nature structural & molecular biology (01.11.2010)
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Applications of Cryo-EM in small molecule and biologics drug design
Lees, Joshua A, Dias, Joao M, Han, Seungil
Published in Biochemical Society transactions (17.12.2021)
Published in Biochemical Society transactions (17.12.2021)
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BNT162b vaccines protect rhesus macaques from SARS-CoV-2
Vogel, Annette B., Kanevsky, Isis, Che, Ye, Swanson, Kena A., Muik, Alexander, Vormehr, Mathias, Kranz, Lena M., Walzer, Kerstin C., Hein, Stephanie, Güler, Alptekin, Loschko, Jakob, Maddur, Mohan S., Ota-Setlik, Ayuko, Tompkins, Kristin, Cole, Journey, Lui, Bonny G., Ziegenhals, Thomas, Plaschke, Arianne, Eisel, David, Dany, Sarah C., Fesser, Stephanie, Erbar, Stephanie, Bates, Ferdia, Schneider, Diana, Jesionek, Bernadette, Sänger, Bianca, Wallisch, Ann-Kathrin, Feuchter, Yvonne, Junginger, Hanna, Krumm, Stefanie A., Heinen, André P., Adams-Quack, Petra, Schlereth, Julia, Schille, Stefan, Kröner, Christoph, de la Caridad Güimil Garcia, Ramón, Hiller, Thomas, Fischer, Leyla, Sellers, Rani S., Choudhary, Shambhunath, Gonzalez, Olga, Vascotto, Fulvia, Gutman, Matthew R., Fontenot, Jane A., Hall-Ursone, Shannan, Brasky, Kathleen, Griffor, Matthew C., Han, Seungil, Su, Andreas A. H., Lees, Joshua A., Nedoma, Nicole L., Mashalidis, Ellene H., Sahasrabudhe, Parag V., Tan, Charles Y., Pavliakova, Danka, Singh, Guy, Fontes-Garfias, Camila, Pride, Michael, Scully, Ingrid L., Ciolino, Tara, Obregon, Jennifer, Gazi, Michal, Carrion, Ricardo, Alfson, Kendra J., Kalina, Warren V., Kaushal, Deepak, Shi, Pei-Yong, Klamp, Thorsten, Rosenbaum, Corinna, Kuhn, Andreas N., Türeci, Özlem, Dormitzer, Philip R., Jansen, Kathrin U., Sahin, Ugur
Published in Nature (London) (08.04.2021)
Published in Nature (London) (08.04.2021)
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Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine
Che, Ye, Gribenko, Alexey V, Song, Xi, Handke, Luke D, Efferen, Kari S, Tompkins, Kristin, Kodali, Srinivas, Nunez, Lorna, Prasad, A Krishna, Phelan, Lynn M, Ammirati, Mark, Yu, Xiaodi, Lees, Joshua A, Chen, Wei, Martinez, Lyndsey, Roopchand, Vidia, Han, Seungil, Qiu, Xiayang, DeVincenzo, John P, Jansen, Kathrin U, Dormitzer, Philip R, Swanson, Kena A
Published in Science translational medicine (26.04.2023)
Published in Science translational medicine (26.04.2023)
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Cyclosporine A sterically inhibits statin transport by solute carrier OATP1B1
Sung, Min Woo, Hu, Kuan, Hurlimann, Lea M., Lees, Joshua A., Fennell, Kimberly F., West, Mark A., Costales, Chester, Rodrigues, Amilcar David, Zimmermann, Iwan, Dawson, Roger J.P., Liu, Shenping, Han, Seungil
Published in The Journal of biological chemistry (01.05.2025)
Published in The Journal of biological chemistry (01.05.2025)
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Architecture of the human PI4KIIIα lipid kinase complex
Lees, Joshua A., Zhang, Yixiao, Oh, Michael S., Schauder, Curtis M., Yu, Xiaoling, Baskin, Jeremy M., Dobbs, Kerry, Notarangelo, Luigi D., De Camilli, Pietro, Walz, Thomas, Reinisch, Karin M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2017)
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Biallelic PI4KA variants cause neurological, intestinal and immunological disease
Salter, Claire G, Cai, Yiying, Lo, Bernice, Helman, Guy, Taylor, Henry, McCartney, Amber, Leslie, Joseph S, Accogli, Andrea, Zara, Federico, Traverso, Monica, Fasham, James, Lees, Joshua A, Ferla, Matteo P, Chioza, Barry A, Wenger, Olivia, Scott, Ethan, Cross, Harold E, Crawford, Joanna, Warshawsky, Ilka, Keisling, Matthew, Agamanolis, Dimitris, Ward Melver, Catherine, Cox, Helen, Elawad, Mamoun, Marton, Tamas, Wakeling, Matthew N, Holzinger, Dirk, Tippelt, Stephan, Munteanu, Martin, Valcheva, Deyana, Deal, Christin, Van Meerbeke, Sara, Walsh Vockley, Catherine, Butte, Manish J, Acar, Utkucan, van der Knaap, Marjo S, Korenke, G Christoph, Kotzaeridou, Urania, Balla, Tamas, Simons, Cas, Uhlig, Holm H, Crosby, Andrew H, De Camilli, Pietro, Wolf, Nicole I, Baple, Emma L
Published in Brain (London, England : 1878) (31.12.2021)
Published in Brain (London, England : 1878) (31.12.2021)
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BNT162b vaccines are immunogenic and protect non-human primates against SARS-CoV-2
Vogel, Annette B, Kanevsky, Isis, Ye Che, Swanson, Kena A, Muik, Alexander, Vormehr, Mathias, Kranz, Lena M, Walzer, Kerstin C, Hein, Stephanie, Güler, Alptekin, Loschko, Jakob, Maddur, Mohan S, Ota-Setlik, Ayuko, Tompkins, Kristin, Cole, Journey, Lui, Bonny G, Ziegenhals, Thomas, Plaschke, Arianne, Eisel, David, Dany, Sarah C, Fesser, Stephanie, Erbar, Stephanie, Bates, Ferdia, Schneider, Diana, Jesionek, Bernadette, Sänger, Bianca, Wallisch, Ann-Kathrin, Feuchter, Yvonne, Junginger, Hanna, Krumm, Stefanie A, Heinen, André P, Adams-Quack, Petra, Schlereth, Julia, Schille, Stefan, Kröner, Christoph, Ramón De La Caridad Güimil Garcia, Hiller, Thomas, Fischer, Leyla, Sellers, Rani S, Choudhary, Shambhunath, Gonzalez, Olga, Vascotto, Fulvia, Gutman, Matthew R, Fontenot, Jane A, Hall-Ursone, Shannan, Brasky, Kathleen, Grif, Matthew C, Han, Seungil, Andreas Ah Su, Lees, Joshua A, Nedoma, Nicole L, Mashalidis, Ellene H, Sahasrabudhe, Parag V, Tan, Charles Y, Pavliakova, Danka, Singh, Guy, Fontes-Garfias, Camila, Pride, Michael, Scully, Ingrid L, Ciolino, Tara, Obregon, Jennifer, Gazi, Michal, Carrion, Ricardo, Alfson, Kendra J, Kalina, Warren V, Kaushal, Deepak, Pei-Yong, Shi, Klamp, Thorsten, Rosenbaum, Corinna, Kuhn, Andreas N, Türeci, Özlem, Dormitzer, Philip R, Jansen, Kathrin U, Sahin, Ugur
Published in bioRxiv (11.12.2020)
Published in bioRxiv (11.12.2020)
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A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates
Vogel, Annette B, Kanevsky, Isis, Ye Che, Swanson, Kena A, Muik, Alexander, Vormehr, Mathias, Kranz, Lena M, Walzer, Kerstin C, Hein, Stephanie, Güler, Alptekin, Loschko, Jakob, Maddur, Mohan S, Tompkins, Kristin, Cole, Journey, Lui, Bonny G, Ziegenhals, Thomas, Plaschke, Arianne, Eisel, David, Dany, Sarah C, Fesser, Stephanie, Erbar, Stephanie, Bates, Ferdia, Schneider, Diana, Jesionek, Bernadette, Sänger, Bianca, Wallisch, Ann-Kathrin, Feuchter, Yvonne, Junginger, Hanna, Krumm, Stefanie A, Heinen, André P, Adams-Quack, Petra, Schlereth, Julia, Kröner, Christoph, Hall-Ursone, Shannan, Brasky, Kathleen, Grif, Matthew C, Han, Seungil, Lees, Joshua A, Mashalidis, Ellene H, Sahasrabudhe, Parag V, Tan, Charles Y, Pavliakova, Danka, Singh, Guy, Fontes-Garfias, Camila, Pride, Michael, Scully, Ingrid L, Ciolino, Tara, Obregon, Jennifer, Gazi, Michal, Carrion, Ricardo, Alfson, Kendra J, Kalina, Warren V, Kaushal, Deepak, Pei-Yong, Shi, Klamp, Thorsten, Rosenbaum, Corinna, Kuhn, Andreas N, Türeci, Özlem, Dormitzer, Philip R, Jansen, Kathrin U, Sahin, Ugur
Published in bioRxiv (08.09.2020)
Published in bioRxiv (08.09.2020)
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Structure-Based Design of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine
Silmon de Monerri, Natalie C., Che, Ye, Lees, Joshua A., Jasti, Jayasankar, Wu, Huixian, Griffor, Matthew C., Kodali, Srinivas, Hawkins, Julio Caesar, Lypowy, Jacqueline, Ponce, Christopher, Curley, Kieran, Esadze, Alexandre, Carcamo, Juan, Keeney, David, Illenberger, Arthur, Matsuka, Yury V., Shanker, Suman, Chorro, Laurent, Gribenko, Alexey V., Han, Seungil, Anderson, Annaliesa S., Donald, Robert G. K.
Published in bioRxiv (10.06.2024)
Published in bioRxiv (10.06.2024)
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