A Phase Ib, Dose-Finding Study of Multiple Doses of Remimazolam (CNS 7056) in Volunteers Undergoing Colonoscopy
Worthington, Mark T, Antonik, Laurie J, Goldwater, D Ronald, Lees, James P, Wilhelm-Ogunbiyi, Karin, Borkett, Keith M, Mitchell, Mack C
Published in Anesthesia and analgesia (01.11.2013)
Published in Anesthesia and analgesia (01.11.2013)
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Journal Article
Lipid regulation of hERG1 channel function
Miranda, Williams E, Guo, Jiqing, Mesa-Galloso, Haydee, Corradi, Valentina, Lees-Miller, James P, Tieleman, D Peter, Duff, Henry J, Noskov, Sergei Yu
Published in Nature communications (03.03.2021)
Published in Nature communications (03.03.2021)
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Journal Article
The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β
Bracey, Nathan A., Beck, Paul L., Muruve, Daniel A., Hirota, Simon A., Guo, Jiqing, Jabagi, Habib, Wright Jr, James R., MacDonald, Justin A., Lees‐Miller, James P., Roach, Daniel, Semeniuk, Lisa M., Duff, Henry J.
Published in Experimental physiology (01.02.2013)
Published in Experimental physiology (01.02.2013)
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Journal Article
A Phase IIa, Randomized, Double-Blind Study of Remimazolam (CNS 7056) Versus Midazolam for Sedation in Upper Gastrointestinal Endoscopy
Borkett, Keith M, Riff, Dennis S, Schwartz, Howard I, Winkle, Peter J, Pambianco, Daniel J, Lees, James P, Wilhelm-Ogunbiyi, Karin
Published in Anesthesia and analgesia (01.04.2015)
Published in Anesthesia and analgesia (01.04.2015)
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Journal Article
Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: Safety and efficacy results from a randomized placebo-controlled phase 2 study
Mangino, Julie E., Firstenberg, Michael S., Milewski, Rita K.C., Rhys-Williams, William, Lees, James P., Dane, Aaron, Love, William G., Gonzalez Moreno, Jesus
Published in Infection control and hospital epidemiology (01.07.2023)
Published in Infection control and hospital epidemiology (01.07.2023)
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Journal Article
NS1643 Interacts around L529 of hERG to Alter Voltage Sensor Movement on the Path to Activation
Guo, Jiqing, Cheng, Yen May, Lees-Miller, James P., Perissinotti, Laura L., Claydon, Tom W., Hull, Christina M., Thouta, Samrat, Roach, Daniel E., Durdagi, Serdar, Noskov, Sergei Y., Duff, Henry J.
Published in Biophysical journal (24.03.2015)
Published in Biophysical journal (24.03.2015)
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Journal Article
Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease
Lees-Miller, James P., Cobban, Alexander, Katsonis, Panagiotis, Bacolla, Albino, Tsutakawa, Susan E., Hammel, Michal, Meek, Katheryn, Anderson, Dave W., Lichtarge, Olivier, Tainer, John A., Lees-Miller, Susan P.
Published in Progress in biophysics and molecular biology (01.08.2021)
Published in Progress in biophysics and molecular biology (01.08.2021)
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Journal Article
A randomised controlled trial on the efficacy and side-effect profile (nausea/vomiting/sedation) of morphine-6-glucuronide versus morphine for post-operative pain relief after major abdominal surgery
Binning, Alexander R, Przesmycki, Krzysztof, Sowinski, Piotr, Morrison, Lachlan M M, Smith, Terry W, Marcus, Paul, Lees, James P, Dahan, Albert
Published in European journal of pain (01.04.2011)
Published in European journal of pain (01.04.2011)
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Journal Article
Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4
Lees-Miller, James P, Guo, Jiqing, Wang, Yibo, Perissinotti, Laura L, Noskov, Sergei Y, Duff, Henry J
Published in Journal of molecular and cellular cardiology (01.08.2015)
Published in Journal of molecular and cellular cardiology (01.08.2015)
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Journal Article
Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643
Durdagi, Serdar, Guo, Jiqing, Lees-Miller, James P, Noskov, Sergei Y, Duff, Henry J
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
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Journal Article
Structural insights into the role of DNA-PK as a master regulator in NHEJ
Chen, Siyu, Lees-Miller, James P., He, Yuan, Lees-Miller, Susan P.
Published in Genome instability & disease (2021)
Published in Genome instability & disease (2021)
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Journal Article
In response to Melgari et al. “hERG potassium channel inhibition by ivabradine requires channel gating”
Lees-Miller, James P, Guo, Jiqing, Wang, Yibo, Perissinotti, Laura L, Noskov, Sergei Y, Duff, Henry J
Published in Journal of molecular and cellular cardiology (01.10.2015)
Published in Journal of molecular and cellular cardiology (01.10.2015)
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Journal Article
Interactions of H562 in the S5 Helix with T618 and S621 in the Pore Helix Are Important Determinants of hERG1 Potassium Channel Structure and Function
Lees-Miller, James P., Subbotina, Julia O., Guo, Jiqing, Yarov-Yarovoy, Vladimir, Noskov, Sergei Y., Duff, Henry J.
Published in Biophysical journal (06.05.2009)
Published in Biophysical journal (06.05.2009)
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Journal Article
Role of Mutation and Pharmacologic Block of Human KCNH2 in Vasculogenesis and Fetal Mortality: Partial Rescue by Transforming Growth Factor-β
Teng, Guoqi, Zhao, Xiang, Lees-Miller, James P, Belke, Darrell, Shi, Chunhua, Chen, Yongxiang, O’Brien, Edward R, Fedak, Paul W, Bracey, Nathan, Cross, James C, Duff, Henry J
Published in Circulation. Arrhythmia and electrophysiology (01.04.2015)
Published in Circulation. Arrhythmia and electrophysiology (01.04.2015)
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Journal Article
Homozygous Missense N629D hERG (KCNH2) Potassium Channel Mutation Causes Developmental Defects in the Right Ventricle and Its Outflow Tract and Embryonic Lethality
Teng, Guo Qi, Zhao, Xian, Lees-Miller, James P, Quinn, F Russell, Li, Pin, Rancourt, Derrick E, London, Barry, Cross, James C, Duff, Henry J
Published in Circulation research (05.12.2008)
Published in Circulation research (05.12.2008)
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Journal Article
Selective Knockout of Mouse ERG1 B Potassium Channel Eliminates IKr in Adult Ventricular Myocytes and Elicits Episodes of Abrupt Sinus Bradycardia
Lees-Miller, James P., Guo, Jiqing, Somers, Julie R., Roach, Dan E., Sheldon, Robert S., Rancourt, Derrick E., Duff, Henry J.
Published in Molecular and Cellular Biology (01.03.2003)
Published in Molecular and Cellular Biology (01.03.2003)
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Journal Article
iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin
Somers, Julie R, Beck, Paul L, Lees-Miller, James P, Roach, Daniel, Li, Yan, Guo, J, Loken, Steven, Zhan, Shan, Semeniuk, Lisa, Duff, Henry J
Published in American journal of physiology. Heart and circulatory physiology (01.09.2008)
Published in American journal of physiology. Heart and circulatory physiology (01.09.2008)
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