Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
Leenay, Ryan T., Maksimchuk, Kenneth R., Slotkowski, Rebecca A., Agrawal, Roma N., Gomaa, Ahmed A., Briner, Alexandra E., Barrangou, Rodolphe, Beisel, Chase L.
Published in Molecular cell (07.04.2016)
Published in Molecular cell (07.04.2016)
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Journal Article
Current and future prospects for CRISPR-based tools in bacteria
Luo, Michelle L., Leenay, Ryan T., Beisel, Chase L.
Published in Biotechnology and bioengineering (01.05.2016)
Published in Biotechnology and bioengineering (01.05.2016)
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Journal Article
Modular one-pot assembly of CRISPR arrays enables library generation and reveals factors influencing crRNA biogenesis
Liao, Chunyu, Ttofali, Fani, Slotkowski, Rebecca A., Denny, Steven R., Cecil, Taylor D., Leenay, Ryan T., Keung, Albert J., Beisel, Chase L.
Published in Nature communications (03.07.2019)
Published in Nature communications (03.07.2019)
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Journal Article
A functional map of HIV-host interactions in primary human T cells
Hiatt, Joseph, Hultquist, Judd F., McGregor, Michael J., Bouhaddou, Mehdi, Leenay, Ryan T., Simons, Lacy M., Young, Janet M., Haas, Paige, Roth, Theodore L., Tobin, Victoria, Wojcechowskyj, Jason A., Woo, Jonathan M., Rathore, Ujjwal, Cavero, Devin A., Shifrut, Eric, Nguyen, Thong T., Haas, Kelsey M., Malik, Harmit S., Doudna, Jennifer A., May, Andrew P., Marson, Alexander, Krogan, Nevan J.
Published in Nature communications (01.04.2022)
Published in Nature communications (01.04.2022)
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Journal Article
Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression
Luo, Michelle L, Mullis, Adam S, Leenay, Ryan T, Beisel, Chase L
Published in Nucleic acids research (01.01.2015)
Published in Nucleic acids research (01.01.2015)
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Journal Article
Genome Editing with CRISPR-Cas9 in Lactobacillus plantarum Revealed That Editing Outcomes Can Vary Across Strains and Between Methods
Leenay, Ryan T, Vento, Justin M, Shah, Malay, Martino, Maria Elena, Leulier, François, Beisel, Chase L
Published in Biotechnology journal (01.03.2019)
Published in Biotechnology journal (01.03.2019)
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Journal Article
Large dataset enables prediction of repair after CRISPR–Cas9 editing in primary T cells
Leenay, Ryan T., Aghazadeh, Amirali, Hiatt, Joseph, Tse, David, Roth, Theodore L., Apathy, Ryan, Shifrut, Eric, Hultquist, Judd F., Krogan, Nevan, Wu, Zhenqin, Cirolia, Giana, Canaj, Hera, Leonetti, Manuel D., Marson, Alexander, May, Andrew P., Zou, James
Published in Nature biotechnology (01.09.2019)
Published in Nature biotechnology (01.09.2019)
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Journal Article
Targeted In Vivo Genome Modification
Maynard, Lucy, Paulk, Nicole K, Mignardi, Marco, May, Andrew P, Tham, Eleonore, Kumar, Gagandeep Renuka, Leenay, Ryan T
Year of Publication 05.05.2022
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Year of Publication 05.05.2022
Patent
TARGETED IN VIVO GENOME MODIFICATION
MAYNARD, Lucy, PAULK, Nicole K, KUMAR, Gagandeep Renuka, LEENAY, Ryan T, MAY, Andrew P, THAM, Eleonore, MIGNARDI, Marco
Year of Publication 16.07.2020
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Year of Publication 16.07.2020
Patent
Systematic characterization of genome editing in primary T cells reveals proximal genomic insertions and enables machine learning prediction of CRISPR-Cas9 DNA repair outcomes
Leenay, Ryan T, Aghazadeh, Amirali, Hiatt, Joseph, Tse, David, Judd Hulquist, Krogan, Nevan, Wu, Zhenqin, Marson, Alexander, May, Andrew P, Zou, James
Published in bioRxiv (31.08.2018)
Published in bioRxiv (31.08.2018)
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Paper
One-step assembly of large CRISPR arrays enables multi-functional targeting and reveals constraints on array design
Liao, Chunyu, Ttofali, Fani, Slotkowski, Rebecca A, Denny, Steven R, Cecil, Taylor D, Leenay, Ryan T, Keung, Albert J, Beisel, Chase L
Published in bioRxiv (02.05.2018)
Published in bioRxiv (02.05.2018)
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Paper