Cathepsin-S degraded decorin are elevated in fibrotic lung disorders - development and biological validation of a new serum biomarker
Kehlet, S N, Bager, C L, Willumsen, N, Dasgupta, B, Brodmerkel, C, Curran, M, Brix, S, Leeming, D J, Karsdal, M A
Published in BMC pulmonary medicine (09.08.2017)
Published in BMC pulmonary medicine (09.08.2017)
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Estimation of serum “true collagen type III formation” (Pro-C3) levels as a marker of non-alcoholic steatohepatitis in a prospective cohort
Leeming, D.J, Grove, J.I, Kaye, P, Hoad, C, Francis, S, Nielsen, M.J, Karsdal, M.A, Guha, I.N, Aithal, G.P
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Journal Article
Should subchondral bone turnover be targeted when treating osteoarthritis?
Karsdal, M.A., M.Sc., Ph.D, Leeming, D.J., M.Sc, Dam, E.B., M.Sc., Ph.D, Henriksen, K., M.Sc., Ph.D, Alexandersen, P., M.Sc., Ph.D, Pastoureau, P., Ph.D, Altman, R.D., M.D, Christiansen, C., M.D
Published in Osteoarthritis and cartilage (01.06.2008)
Published in Osteoarthritis and cartilage (01.06.2008)
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Serum Pro-C3 combined with clinical parameters is superior to established serological fibrosis tests at identifying patients with advanced fibrosis among patients with non-alcoholic fatty liver disease
Daniels, S.J, Nielsen, M.J, Krag, A, Eslam, M, Karsdal, M.A, Leeming, D.J, George, J
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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427 A serum biomarker reflecting basement membrane degradation predicts mortality in breast cancer patients one year prior to detection of metastatic disease
Willumsen, N, Bager, C.L, Leeming, D.J, Karsdal, M.A, Bay-Jensen, A.C, Brandslund, I
Published in European journal of cancer (1990) (01.09.2015)
Published in European journal of cancer (1990) (01.09.2015)
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Journal Article
Contribution of the advanced glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar vertebrae
Viguet-Carrin, S., Roux, J.P., Arlot, M.E., Merabet, Z., Leeming, D.J, Byrjalsen, I., Delmas, P.D., Bouxsein, M.L.
Published in Bone (New York, N.Y.) (01.11.2006)
Published in Bone (New York, N.Y.) (01.11.2006)
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A novel serological type III collagen a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) degradation marker for assessment of the extracellular matrix remodeling in patients with osteoarthritis
Bay-Jensen, A.-C, Kjaer-Pedersen, K, Arendt-Nielsen, L, Simonsen, O, Zheng, Q, Leeming, D.J, Karsdal, M.A
Published in Osteoarthritis and cartilage (01.04.2016)
Published in Osteoarthritis and cartilage (01.04.2016)
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274 Development of a novel marker for detection of degradation and formation of fibronectin in cancer ex vivo models
Bager, C.L, Bay-Jensen, A.C, Leeming, D.J, Gudmann, N.S, Karsdal, M, Balslev, I, Christiansen, A.P, Høgdall, E, He, Y
Published in European journal of cancer (1990) (01.09.2015)
Published in European journal of cancer (1990) (01.09.2015)
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275 ECM degradation products are released from kidney tumor tissue and adjacent tissue
Bager, C.L, Willumsen, N, Quilez-Alvarez, A, Bay-Jensen, A.C, Leeming, D.J, Karsdal, M, Christiansen, A.P, Balslev, I, Høgdall, E
Published in European journal of cancer (1990) (01.09.2015)
Published in European journal of cancer (1990) (01.09.2015)
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Journal Article
220 Specific protein degradation products of collagen and vimentin as well as fibronectin are released from the tumor core and adjacent tissue in a human colorectal tumor ex vivo model - biomarker potential
Willumsen, N, Bager, C.L, Bay-Jensen, A.C, Quilez Alvarez, A, Harling, H, Leeming, D.J, Karsdal, M.A, Jorgensen, L. Nannestad
Published in European journal of cancer (1990) (01.09.2015)
Published in European journal of cancer (1990) (01.09.2015)
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Journal Article
Levels of circulating MMP-7 degraded elastin are elevated in pulmonary disorders
Kristensen, J.H., Larsen, L., Dasgupta, B., Brodmerkel, C., Curran, M., Karsdal, M.A., Sand, J.M.B., Willumsen, N., Knox, A.J., Bolton, C.E., Johnson, S.R., Hägglund, P., Svensson, B., Leeming, D.J.
Published in Clinical biochemistry (01.11.2015)
Published in Clinical biochemistry (01.11.2015)
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A Serological Marker of Collagen Type III Crosslinking Correlates Strongly with Severity of Liver Disease
Karsdal, M.A, Nielsen, M.J, Thiele, M, Genovese, F, Madsen, B.S, Hansen, J.F, Møller, L, Detlefsen, S, de Muckadell, O.S, Leeming, D.J, Krag, A
Published in Journal of hepatology (2016)
Published in Journal of hepatology (2016)
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Serological Biomarkers of Extracellular Matrix Remodeling Predict Transplant-Free Survival in Primary Sclerosing Cholangitis Patients
Nielsen, M.J, Thorburn, D, Leeming, D.J, Hov, J.R, Moum, B, Saffioti, F, Gilja, O.H, Boberg, K.M, Mazza, G, Pinzani, M, Karlsen, T.H, Karsdal, M.A, Vesterhus, M
Published in Journal of hepatology (2016)
Published in Journal of hepatology (2016)
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Journal Article
A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis
Leeming, D J, Willumsen, N, Sand, J M B, Holm Nielsen, S, Dasgupta, B, Brodmerkel, C, Curran, M, Bager, C L, Karsdal, M A
Published in Biochemistry and biophysics reports (01.03.2019)
Published in Biochemistry and biophysics reports (01.03.2019)
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Journal Article
Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development
Karsdal, M.A., Henriksen, K., Leeming, D.J., Mitchell, P., Duffin, K., Barascuk, N., Klickstein, L., Aggarwal, P., Nemirovskiy, O., Byrjalsen, I., Qvist, P., Bay-Jensen, A.C., Dam, E.B., Madsen, S.H., Christiansen, C.
Published in Biomarkers (01.05.2009)
Published in Biomarkers (01.05.2009)
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436 The Prospective Epidemiologic Risk Factor (PERF I) Study: A novel prognostic serum biomarker reflecting type I collagen degradation is associated with tumor burden
Kehlet, S.N, Bager, C.L, Willumsen, N, Dragsb, K, Neergaard, J.S, Hansen, H.B, Bay-Jensen, A.C, Oersnes-Leeming, D.J, Christiansen, C, Karsdal, M.A
Published in European journal of cancer (1990) (01.09.2015)
Published in European journal of cancer (1990) (01.09.2015)
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Journal Article
P1018 MARKERS OF COLLAGEN REMODELING DETECT CLINICALLY SIGNIFICANT FIBROSIS IN CHRONIC HEPATITIS C PATIENTS
Nielsen, M.J, Kazankov, K, Leeming, D.J, Karsdal, M.A, Krag, A, Barrera, F, George, J, Grønbæk, H
Published in Journal of hepatology (01.04.2014)
Published in Journal of hepatology (01.04.2014)
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