Isoform-specific antagonists of exchange proteins directly activated by cAMP
Tsalkova, Tamara, Mei, Fang C, Li, Sheng, Chepurny, Oleg G, Leech, Colin A, Liu, Tong, Holz, George G, Woods, Virgil L, Cheng, Xiaodong
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2012)
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Journal Article
Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation
Xie, Han, Yepuri, Natesh, Meng, Qinghe, Dhawan, Ravi, Leech, Colin A., Chepurny, Oleg G., Holz, George G., Cooney, Robert N.
Published in Reviews in endocrine & metabolic disorders (01.12.2020)
Published in Reviews in endocrine & metabolic disorders (01.12.2020)
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Journal Article
Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion
Schwede, Frank, Chepurny, Oleg G, Kaufholz, Melanie, Bertinetti, Daniela, Leech, Colin A, Cabrera, Over, Zhu, Yingmin, Mei, Fang, Cheng, Xiaodong, Manning Fox, Jocelyn E, MacDonald, Patrick E, Genieser, Hans-G, Herberg, Friedrich W, Holz, George G
Published in Molecular endocrinology (Baltimore, Md.) (01.07.2015)
Published in Molecular endocrinology (Baltimore, Md.) (01.07.2015)
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Journal Article
Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1
Leech, Colin A., Chepurny, Oleg G., Holz, George G.
Published in Incretins and Insulin Secretion (2010)
Published in Incretins and Insulin Secretion (2010)
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Book Chapter
Journal Article
Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag
Chepurny, Oleg G, Bertinetti, Daniela, Diskar, Mandy, Leech, Colin A, Afshari, Parisa, Tsalkova, Tamara, Cheng, Xiaodong, Schwede, Frank, Genieser, Hans-G, Herberg, Friedrich W, Holz, George G
Published in Molecular endocrinology (Baltimore, Md.) (01.08.2013)
Published in Molecular endocrinology (Baltimore, Md.) (01.08.2013)
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Journal Article
Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter
Lechner, Andreas, Leech, Colin A, Abraham, Elizabeth J, Nolan, Anna L, Habener, Joel F
Published in Biochemical and biophysical research communications (03.05.2002)
Published in Biochemical and biophysical research communications (03.05.2002)
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Journal Article
Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans
Dzhura, Igor, Chepurny, Oleg G., Leech, Colin A., Roe, Michael W., Dzhura, Elvira, Xu, Xin, Lu, Youming, Schwede, Frank, Genieser, Hans-G., Smrcka, Alan V., Holz, George G.
Published in Islets (01.05.2011)
Published in Islets (01.05.2011)
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Journal Article
Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon
Cabrera, Over, Ficorilli, James, Shaw, Janice, Echeverri, Felipe, Schwede, Frank, Chepurny, Oleg G., Leech, Colin A., Holz, George G.
Published in The Journal of biological chemistry (01.02.2022)
Published in The Journal of biological chemistry (01.02.2022)
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Journal Article
Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets
Veluthakal, Rajakrishnan, Chepurny, Oleg G, Leech, Colin A, Schwede, Frank, Holz, George G, Thurmond, Debbie C
Published in Diabetes (New York, N.Y.) (01.10.2018)
Published in Diabetes (New York, N.Y.) (01.10.2018)
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Journal Article
Huntington's Disease of the Endocrine Pancreas: Insulin Deficiency and Diabetes Mellitus due to Impaired Insulin Gene Expression
Andreassen, Ole A., Dedeoglu, Alpaslan, Stanojevic, Violeta, Hughes, Duncan B., Browne, Susan E., Leech, Colin A., Ferrante, Robert J., Habener, Joel F., Beal, M.Flint, Thomas, Melissa K.
Published in Neurobiology of disease (01.12.2002)
Published in Neurobiology of disease (01.12.2002)
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Journal Article
Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP
Chepurny, Oleg G., Matsoukas, Minos-Timotheos, Liapakis, George, Leech, Colin A., Milliken, Brandon T., Doyle, Robert P., Holz, George G.
Published in The Journal of biological chemistry (08.03.2019)
Published in The Journal of biological chemistry (08.03.2019)
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Journal Article
The alpha‐7 nicotinic acetylcholine receptor agonist GTS‐21 engages the glucagon‐like peptide‐1 incretin hormone axis to lower levels of blood glucose in db/db mice
Meng, Qinghe, Chepurny, Oleg G., Leech, Colin A., Pruekprasert, Napat, Molnar, Megan E., Collier, James Jason, Cooney, Robert N., Holz, George G.
Published in Diabetes, obesity & metabolism (01.07.2022)
Published in Diabetes, obesity & metabolism (01.07.2022)
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Journal Article
“A-kinase” regulator runs amok to provide a paradigm shift in cAMP signaling
Holz, George G., Chepurny, Oleg G., Leech, Colin A.
Published in The Journal of biological chemistry (15.02.2019)
Published in The Journal of biological chemistry (15.02.2019)
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Journal Article
The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells
Liew, Chong Wee, Bochenski, Jacek, Kawamori, Dan, Hu, Jiang, Leech, Colin A, Wanic, Krzysztof, Malecki, Maciej, Warram, James H, Qi, Ling, Krolewski, Andrzej S, Kulkarni, Rohit N
Published in The Journal of clinical investigation (01.08.2010)
Published in The Journal of clinical investigation (01.08.2010)
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Journal Article
Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM
Kelley, Grant G., Chepurny, Oleg G., Schwede, Frank, Genieser, Hans-G., Leech, Colin A., Roe, Michael W., Li, Xiangquan, Dzhura, Igor, Dzhura, Elvira, Afshari, Parisa, Holz, George G.
Published in Islets (01.11.2009)
Published in Islets (01.11.2009)
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Journal Article
Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors
Chepurny, Oleg G, Bonaccorso, Ron L, Leech, Colin A, Wöllert, Torsten, Langford, George M, Schwede, Frank, Roth, Christian L, Doyle, Robert P, Holz, George G
Published in Scientific reports (28.02.2018)
Published in Scientific reports (28.02.2018)
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Journal Article
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
Basile, Giorgio, Vetere, Amedeo, Hu, Jiang, Ijaduola, Oluwaseun, Zhang, Yi, Liu, Ka-Cheuk, Eltony, Amira M., De Jesus, Dario F., Fukuda, Kazuki, Doherty, Grace, Leech, Colin A., Chepurny, Oleg G., Holz, George G., Yun, Seok-Hyun, Andersson, Olov, Choudhary, Amit, Wagner, Bridget K., Kulkarni, Rohit N.
Published in Cell metabolism (11.07.2023)
Published in Cell metabolism (11.07.2023)
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Journal Article
Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 β-Cells
Leech, Colin A., Kopp, Richard F., Nelson, Heather A., Nandi, Jyotirmoy, Roe, Michael W.
Published in The Journal of biological chemistry (10.02.2017)
Published in The Journal of biological chemistry (10.02.2017)
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Journal Article
Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells
Leech, Colin A., Dzhura, Igor, Chepurny, Oleg G., Kang, Guoxin, Schwede, Frank, Genieser, Hans-G., Holz, George G.
Published in Progress in biophysics and molecular biology (01.11.2011)
Published in Progress in biophysics and molecular biology (01.11.2011)
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Journal Article
GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion
Chepurny, Oleg G, Holz, George G, Roe, Michael W, Leech, Colin A
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2016)
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2016)
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Journal Article