Selective and predicable amine conjugation sites by kinetic characterization under excess reagents
Huang, Wei-Chun, Huang, Li-Juan, Hsu, Liang-Sheng, Huang, Shih-Ting, Lo, Wen-Ting, Wang, Tzu-Fan, Sun, Wei-Ting, Wei, Win-Yin, Lee, Ying-Shuan, Chuang, Shih-Hsien, Lee, Chao-Pin, Chou, Ho-Hsuan, Chen, Shu-Hui
Published in Scientific reports (27.10.2021)
Published in Scientific reports (27.10.2021)
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Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy
Chuang, Shih-Hsien, Lee, Ying-Shuan E., Huang, Lynn Y.L., Chen, Chi-Kuan, Lai, Chun-Liang, Lin, Yu-Hsiang, Yang, Ju-Ying, Yang, Sheng-Chuan, Chang, Lien-Hsiang, Chen, Ching-Hui, Liu, Chia-Wei, Lin, Her-Sheng, Lee, Yi-Ru, Huang, Kuan Pin, Fu, Kuo Chu, Jen, Hsueh-Min, Lai, Jun-Yu, Jian, Pei-Shiou, Wang, Yu-Chuan, Hsueh, Wen-Yun, Tsai, Pei-Yi, Hong, Wan-Hua, Chang, Chia-Chi, Wu, Diana ZC, Wu, Jinn, Chen, Meng-Hsin, Yu, Kuo-Ming, Chern, Ching Yuh, Chang, Jia-Ming, Lau, Johnson Y.N., Huang, Jiann-Jyh
Published in European journal of medicinal chemistry (01.04.2020)
Published in European journal of medicinal chemistry (01.04.2020)
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Copper(I)-Catalyzed Nitrile-Addition/ N -Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6 H -indolo[3,2- c ]quinolin-6-ones as Potent Topoisomerase-I Inhibitors
Hsueh, Wen-Yun, Lee, Ying-Shuan E, Huang, Min-Sian, Lai, Chin-Hung, Gao, Yu-Sheng, Lin, Jo-Chu, Chen, Yu-Fen, Chang, Chih-Lin, Chou, Shan-Yen, Chen, Shyh-Fong, Lu, Yann-Yu, Chang, Lien-Hsiang, Lin, Shu Fu, Lin, Yu-Hsiang, Hsu, Pi-Chen, Wei, Win-Yin, Huang, Ya-Chi, Kao, Yi-Feng, Teng, Li-Wei, Liu, Hung-Huang, Chen, Ying-Chou, Yuan, Ta-Tung, Chan, Ya-Wen, Huang, Po-Hsun, Chao, Yu-Ting, Huang, Shin-Yi, Jian, Bo-Han, Huang, Hsin-Yi, Yang, Sheng-Chuan, Lo, Tzu-Hao, Huang, Guan-Ru, Wang, Shao-Yun, Lin, Her-Sheng, Chuang, Shih-Hsien, Huang, Jiann-Jyh
Published in Journal of medicinal chemistry (11.02.2021)
Published in Journal of medicinal chemistry (11.02.2021)
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Discovery of 4‑Aryl‑N‑arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of in Vitro Potencies and Pharmacokinetic Properties
Lee, Ying-Shuan E, Chuang, Shih-Hsien, Huang, Lynn Y. L, Lai, Chun-Liang, Lin, Yu-Hsiang, Yang, Ju-Ying, Liu, Chia-Wei, Yang, Sheng-chuan, Lin, Her-Sheng, Chang, Chia-chi, Lai, Jun-Yu, Jian, Pei-Shiou, Lam, King, Chang, Jia-Ming, Lau, Johnson Y. N, Huang, Jiann-Jyh
Published in Journal of medicinal chemistry (22.05.2014)
Published in Journal of medicinal chemistry (22.05.2014)
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Journal Article
Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1
Huang, Lynn Y L, Lee, Ying-Shuan, Huang, Jiann-Jyh, Chang, Chia-chi, Chang, Jia-Ming, Chuang, Shih-Hsien, Kao, Kuo-Jang, Tsai, Yung-Jen, Tsai, Pei-Yi, Liu, Chia-Wei, Lin, Her-Sheng, Lau, Johnson Y N
Published in Journal of experimental & clinical cancer research (09.01.2014)
Published in Journal of experimental & clinical cancer research (09.01.2014)
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Design and synthesis of pyrrole–5-(2,6-dichlorobenzyl)sulfonylindolin-2-ones with C-3′ side chains as potent Met kinase inhibitors
Liu, Chia-Wei, Lai, Chun-Liang, Lin, Yu-Hsiang, Teng, Li-Wei, Yang, Sheng-chuan, Wei, Win-Yin, Lin, Shu Fu, Yang, Ju-Ying, Huang, Hung-Jyun, Wang, Ru-Wen, Chiang, Chao-Cheng, Lee, Mei-Hui, Wang, Yu-Chuan, Chuang, Shih-Hsien, Chang, Jia-Ming, Lee, Ying-Shuan E., Huang, Jiann-Jyh
Published in RSC advances (01.01.2014)
Published in RSC advances (01.01.2014)
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Synthesis and Antiproliferative Activities of Ottelione A Analogues
Chang, Tsai-Yuan, Tu, Yun-Peng, Wei, Win-Yin, Chen, Hsiang Yu, Chen, Chih-Shang, Lee, Ying-Shuan E, Huang, Jiann-Jyh, Sha, Chin-Kang
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
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Journal Article
Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro‑6H‑indolo[3,2‑c]quinolin-6-ones as Potent Topoisomerase‑I Inhibitors
Hsueh, Wen-Yun, Lee, Ying-Shuan E, Huang, Min-Sian, Lai, Chin-Hung, Gao, Yu-Sheng, Lin, Jo-Chu, Chen, Yu-Fen, Chang, Chih-Lin, Chou, Shan-Yen, Chen, Shyh-Fong, Lu, Yann-Yu, Chang, Lien-Hsiang, Lin, Shu Fu, Lin, Yu-Hsiang, Hsu, Pi-Chen, Wei, Win-Yin, Huang, Ya-Chi, Kao, Yi-Feng, Teng, Li-Wei, Liu, Hung-Huang, Chen, Ying-Chou, Yuan, Ta-Tung, Chan, Ya-Wen, Huang, Po-Hsun, Chao, Yu-Ting, Huang, Shin-Yi, Jian, Bo-Han, Huang, Hsin-Yi, Yang, Sheng-Chuan, Lo, Tzu-Hao, Huang, Guan-Ru, Wang, Shao-Yun, Lin, Her-Sheng, Chuang, Shih-Hsien, Huang, Jiann-Jyh
Published in Journal of medicinal chemistry (11.02.2021)
Published in Journal of medicinal chemistry (11.02.2021)
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Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability
Yu, I S, Chen, H J, Lee, Y S, Huang, P H, Lin, S R, Tsai, T W, Lin, S W
Published in Thrombosis and haemostasis (01.11.2000)
Published in Thrombosis and haemostasis (01.11.2000)
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Journal Article
Activity of a novel Hec1-targeted anticancer compound against breast cancer cell lines in vitro and in vivo
Huang, Lynn Y L, Chang, Chia-Chi, Lee, Ying-Shuan, Chang, Jia-Ming, Huang, Jiann-Jyh, Chuang, Shih-Hsien, Kao, Kuo-Jang, Lau, Gillian M G, Tsai, Pei-Yi, Liu, Chia-Wei, Lin, Her-Sheng, Lau, Johnson Y N
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
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Inhibition of Hec1 as a novel approach for treatment of primary liver cancer
Huang, Lynn YL, Chang, Chia-chi, Lee, Ying-Shuan, Huang, Jiann-Jyh, Chuang, Shih-Hsien, Chang, Jia-Ming, Kao, Kuo-Jang, Lau, Gillian MG, Tsai, Pei-Yi, Liu, Chia-wei, Lin, Her-Sheng, Gish, Robert G., Lau, Johnson YN
Published in Cancer chemotherapy and pharmacology (01.09.2014)
Published in Cancer chemotherapy and pharmacology (01.09.2014)
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Abstract C046: A Smo inhibitor DCBCO1303 with potent Hedgehog signaling pathway antagonist activity is highly active in animal tumor model of medulloblastoma and cholangiocarcinoma
Lee, Ying-Shuan E, Kuo, Mann-Yan, Tsai, Pei-Yi, Liu, Chia Wei, Wei, Win Yin
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Nicotine stimulates expression of the PNMT gene through a novel promoter sequence
Evinger, Marian J, Mathew, Elizabeth, Cikos, Stefan, Powers, James F, Lee, Ying-Shuan E, Sheikh, Sabina, Ross, Robert A, Tischler, Arthur S
Published in Journal of molecular neuroscience (01.01.2005)
Published in Journal of molecular neuroscience (01.01.2005)
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IMPROVED MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR
LEE YING SHUAN EDA, CHUANG SHIH HSIEN, HUANG YU LING, LAU JOHNSON, HUANG JIANN JYH
Year of Publication 04.12.2014
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Year of Publication 04.12.2014
Patent
Abstract 813: Development of anti-Globo H ADC against cancer
Sun, Wei-Ting, Chuang, Shih-Hsien, Lee, Chao-Pin, Chen, Yi-Jen, Wei, Win-Yin, Lee, Ying-Shuan, Hsu, Chuan-Lung, Nieh, Yu-Chin, Wu, Chia-Cheng
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 134: A dual mTOR-PI3K inhibitor DCB-HDG2-57 with Hedgehog signaling pathway antagonist activity
Lee, Ying-Shuan, Kuo, Mann-Yan, Liu, Chia Wei, Tseng, Yu-Wen, Wei, Win Yin, Chiou, Shian-Yi, Lin, Her Sheng, Lu, Y.-Y., Liao, Chu-Bin, Pen, Shao-Zheng
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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