Heat Shock Protein 90: Inhibitors in Clinical Trials
Biamonte, Marco A, Van de Water, Ryan, Arndt, Joseph W, Scannevin, Robert H, Perret, Daniel, Lee, Wen-Cherng
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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Journal Article
Small Molecular Inhibitor of Transforming Growth Factor-β Protects Against Development of Radiation-Induced Lung Injury
Anscher, Mitchell S., M.D, Thrasher, Bradley, Zgonjanin, Larisa, Rabbani, Zahid N., M.D, Corbley, Michael J., Ph.D, Fu, Kai, Ph.D, Sun, Lihong, Ph.D, Lee, Wen-Cherng, Ph.D, Ling, Leona E., Ph.D, Vujaskovic, Zeljko, M.D., Ph.D
Published in International journal of radiation oncology, biology, physics (01.07.2008)
Published in International journal of radiation oncology, biology, physics (01.07.2008)
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Journal Article
Stereochemistry–activity relationship of orally active tetralin S1P agonist prodrugs
Ma, Bin, Guckian, Kevin M., Lin, Edward Yin-Shiang, Lee, Wen-Cherng, Scott, Daniel, Kumaravel, Gnanasambandam, Macdonald, Timothy L., Lynch, Kevin R., Black, Cheryl, Chollate, Sowmya, Hahm, Kyungmin, Hetu, Gregg, Jin, Ping, Luo, Yi, Rohde, Ellen, Rossomando, Anthony, Scannevin, Robert, Wang, Joy, Yang, Chunhua
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis
Garrison, Kendra, Hahn, Tobias, Lee, Wen-Cherng, Ling, Leona E., Weinberg, Andrew D., Akporiaye, Emmanuel T.
Published in Cancer Immunology, Immunotherapy (01.04.2012)
Published in Cancer Immunology, Immunotherapy (01.04.2012)
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Journal Article
Strategies for TGF-beta modulation: a review of recent patents
Bonafoux, Dominique, Lee, Wen-Cherng
Published in Expert opinion on therapeutic patents (01.12.2009)
Published in Expert opinion on therapeutic patents (01.12.2009)
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Journal Article
A Kinase-focused Compound Collection: Compilation and Screening Strategy
Sun, Dongyu, Chuaqui, Claudio, Deng, Zhan, Bowes, Scott, Chin, Donovan, Singh, Juswinder, Cullen, Patrick, Hankins, Gretchen, Lee, Wen-Cherng, Donnelly, Jason, Friedman, Jessica, Josiah, Serene
Published in Chemical biology & drug design (01.06.2006)
Published in Chemical biology & drug design (01.06.2006)
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Journal Article
An Abiotic Strategy for the Enantioselective Synthesis of Erythromycin B
Hergenrother, Paul J., Hodgson, Anne, Judd, Andrew S., Lee, Wen-Cherng, Martin, Stephen F.
Published in Angewandte Chemie International Edition (21.07.2003)
Published in Angewandte Chemie International Edition (21.07.2003)
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Journal Article
Duplexed, bead‐based competitive assay for inhibitors of protein kinases
Simons, Peter C., Young, Susan M., Gibaja, Veronica, Lee, Wen‐Cherng, Josiah, Serene, Edwards, Bruce S., Sklar, Larry A.
Published in Cytometry. Part A (01.07.2007)
Published in Cytometry. Part A (01.07.2007)
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Journal Article
Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma
Singh, Juswinder, Adams, Steve, Carter, Mary Beth, Cuervo, Hernan, Lee, Wen-Cherng, Lobb, Roy R, Pepinsky, R Blake, Petter, Russell, Scott, Daniel
Published in Current topics in medicinal chemistry (01.01.2004)
Published in Current topics in medicinal chemistry (01.01.2004)
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Journal Article
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery
Erlanson, Daniel A., Arndt, Joseph W., Cancilla, Mark T., Cao, Kathy, Elling, Robert A., English, Nicki, Friedman, Jessica, Hansen, Stig K., Hession, Cathy, Joseph, Ingrid, Kumaravel, Gnanasambandam, Lee, Wen-Cherng, Lind, Ken E., McDowell, Robert S., Miatkowski, Konrad, Nguyen, Christine, Nguyen, Thinh B., Park, Sophia, Pathan, Nuzhat, Penny, David M., Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Simmons, Robert L., Tangonan, Bradley T., Yang, Wenjin, Sun, Lihong
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Journal Article
A novel small-molecule inhibitor of transforming growth factor β type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection
SUZUKI, Eiji, KIM, Samuel, LING, Leona E, CHEUNG, H.-Kam, CORBLEY, Michael J, XIAMEI ZHANG, LIHONG SUN, FENG SHAN, SINGH, Juswinder, LEE, Wen-Cherng, ALBELDA, Steven M
Published in Cancer research (Chicago, Ill.) (01.03.2007)
Published in Cancer research (Chicago, Ill.) (01.03.2007)
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Journal Article
Intracellular TGF-β Receptor Blockade Abrogates Smad-Dependent Fibroblast Activation In Vitro and In Vivo
Ishida, Wataru, Mori, Yasuji, Lakos, Gabriella, Sun, Lihong, Shan, Feng, Bowes, Scott, Josiah, Serene, Lee, Wen-Cherng, Singh, Juswinder, Ling, Leona E., Varga, John
Published in Journal of investigative dermatology (01.08.2006)
Published in Journal of investigative dermatology (01.08.2006)
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Journal Article
SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model
Fu, Kai, Corbley, Michael J, Sun, Lihong, Friedman, Jessica E, Shan, Feng, Papadatos, James L, Costa, Donald, Lutterodt, Frank, Sweigard, Harry, Bowes, Scott, Choi, Michael, Boriack-Sjodin, P Ann, Arduini, Robert M, Sun, Dongyu, Newman, Miki N, Zhang, Xiamei, Mead, Jonathan N, Chuaqui, Claudio E, Cheung, H-Kam, Zhang, Xin, Cornebise, Mark, Carter, Mary Beth, Josiah, Serene, Singh, Juswinder, Lee, Wen-Cherng, Gill, Alan, Ling, Leona E
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2008)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2008)
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Journal Article
Pyrazolone based TGFβR1 kinase inhibitors
Guckian, Kevin, Carter, Mary Beth, Lin, Edward Yin-Shiang, Choi, Michael, Sun, Lihong, Boriack-Sjodin, P. Ann, Chuaqui, Claudio, Lane, Benjamin, Cheung, Kam, Ling, Leona, Lee, Wen-Cherng
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)
JUSWINDER SINGH, CHUAQUI, Claudio E, PAPADATOS, James L, BOWES, Scott, JOSIAH, Serene, LING, Leona E, BORIACK-SJODIN, P. Ann, LEE, Wen-Cherng, PONTZ, Timothy, CORBLEY, Michael J, CHEUNG, H.-Kam, ARDUINI, Robert M, MEAD, Jonathan N, NEWMAN, Miki N
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Journal Article
Total synthesis of erythromycin B
Breton, Philippe, Hergenrother, Paul J., Hida, Tsuneaki, Hodgson, Anne, Judd, Andrew S., Kraynack, Erica, Kym, Philip R., Lee, Wen-Cherng, Loft, Michael S., Yamashita, Masayuki, Martin, Stephen F.
Published in Tetrahedron (25.06.2007)
Published in Tetrahedron (25.06.2007)
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Journal Article
An Orally Active Small Molecule TGF-β Receptor I Antagonist Inhibits the Growth of Metastatic Murine Breast Cancer
RAUNCH, Matthew P, HAHN, Tobias, LEE, Wen-Cherng, LING, Leona E, AKPORIAYE, Emmanuel T, RAMANATHAPURAM, Lalitha, BRADLEY-DUNLOP, Deborah, MAHADEVAN, Daruka, MERCADO-PIMENTEL, Melania E, RUNYAN, Raymond B, BESSELSEN, David G, XIAMEI ZHANG, CHEUNG, H.-Kam
Published in Anticancer research (01.06.2009)
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Published in Anticancer research (01.06.2009)
Journal Article
2-Aminoimidazoles inhibitors of TGF-β receptor 1
Bonafoux, Dominique, Chuaqui, Claudio, Boriack-Sjodin, P. Ann, Fitch, Chris, Hankins, Gretchen, Josiah, Serene, Black, Cheryl, Hetu, Gregg, Ling, Leona, Lee, Wen-Cherng
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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