Challenges Facing Airway Epithelial Cell-Based Therapy for Cystic Fibrosis
Berical, Andrew, Lee, Rhianna E, Randell, Scott H, Hawkins, Finn
Published in Frontiers in pharmacology (08.02.2019)
Published in Frontiers in pharmacology (08.02.2019)
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A multimodal iPSC platform for cystic fibrosis drug testing
Berical, Andrew, Lee, Rhianna E, Lu, Junjie, Beermann, Mary Lou, Le Suer, Jake A, Mithal, Aditya, Thomas, Dylan, Ranallo, Nicole, Peasley, Megan, Stuffer, Alex, Bukis, Katherine, Seymour, Rebecca, Harrington, Jan, Coote, Kevin, Valley, Hillary, Hurley, Killian, McNally, Paul, Mostoslavsky, Gustavo, Mahoney, John, Randell, Scott H, Hawkins, Finn J
Published in Nature communications (29.07.2022)
Published in Nature communications (29.07.2022)
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Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough
Lee, Rhianna E, Lewis, Catherine A, He, Lihua, Bulik-Sullivan, Emily C, Gallant, Samuel C, Mascenik, Teresa M, Dang, Hong, Cholon, Deborah M, Gentzsch, Martina, Morton, Lisa C, Minges, John T, Theile, Jonathan W, Castle, Neil A, Knowles, Michael R, Kimple, Adam J, Randell, Scott H
Published in The Journal of clinical investigation (15.09.2022)
Published in The Journal of clinical investigation (15.09.2022)
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SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia
Meganck, Rita M., Edwards, Caitlin E., Mallory, Michael L., Lee, Rhianna E., Dang, Hong, Bailey, Alexis B., Wykoff, Jason A., Gallant, Samuel C., Zhu, Deanna R., Yount, Boyd L., Kato, Takafumi, Shaffer, Kendall M., Nakano, Satoko, Cawley, Anne Marie, Sontake, Vishwaraj, Wang, Jeremy R., Hagan, Robert S., Miller, Melissa B., Tata, Purushothama Rao, Randell, Scott H., Tse, Longping V., Ehre, Camille, Okuda, Kenichi, Boucher, Richard C., Baric, Ralph S.
Published in Cell reports (Cambridge) (23.04.2024)
Published in Cell reports (Cambridge) (23.04.2024)
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SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
Hou, Yixuan J, Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, 3rd, Kenneth H, Leist, Sarah R, Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E, Mascenik, Teresa M, Graham, Rachel, Edwards, Caitlin E, Tse, Longping V, Okuda, Kenichi, Markmann, Alena J, Bartelt, Luther, de Silva, Aravinda, Margolis, David M, Boucher, Richard C, Randell, Scott H, Suzuki, Tadaki, Gralinski, Lisa E, Kawaoka, Yoshihiro, Baric, Ralph S
Published in Science (18.12.2020)
Published in Science (18.12.2020)
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SARS-CoV-2 infection of the oral cavity and saliva
Huang, Ni, Pérez, Paola, Kato, Takafumi, Mikami, Yu, Okuda, Kenichi, Gilmore, Rodney C, Conde, Cecilia Domínguez, Gasmi, Billel, Stein, Sydney, Beach, Margaret, Pelayo, Eileen, Maldonado, Jose O, Lafont, Bernard A, Jang, Shyh-Ing, Nasir, Nadia, Padilla, Ricardo J, Murrah, Valerie A, Maile, Robert, Lovell, William, Wallet, Shannon M, Bowman, Natalie M, Meinig, Suzanne L, Wolfgang, Matthew C, Choudhury, Saibyasachi N, Novotny, Mark, Aevermann, Brian D, Scheuermann, Richard H, Cannon, Gabrielle, Anderson, Carlton W, Lee, Rhianna E, Marchesan, Julie T, Bush, Mandy, Freire, Marcelo, Kimple, Adam J, Herr, Daniel L, Rabin, Joseph, Grazioli, Alison, Das, Sanchita, French, Benjamin N, Pranzatelli, Thomas, Chiorini, John A, Kleiner, David E, Pittaluga, Stefania, Hewitt, Stephen M, Burbelo, Peter D, Chertow, Daniel, Frank, Karen, Lee, Janice, Boucher, Richard C, Teichmann, Sarah A, Warner, Blake M, Byrd, Kevin M
Published in Nature medicine (01.05.2021)
Published in Nature medicine (01.05.2021)
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Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia
Okuda, Kenichi, Dang, Hong, Kobayashi, Yoshihiko, Carraro, Gianni, Nakano, Satoko, Chen, Gang, Kato, Takafumi, Asakura, Takanori, Gilmore, Rodney C, Morton, Lisa C, Lee, Rhianna E, Mascenik, Teresa, Yin, Wei-Ning, Barbosa Cardenas, Selene Margarita, O'Neal, Yvonne K, Minnick, Caroline E, Chua, Michael, Quinney, Nancy L, Gentzsch, Martina, Anderson, Carlton W, Ghio, Andrew, Matsui, Hirotoshi, Nagase, Takahide, Ostrowski, Lawrence E, Grubb, Barbara R, Olsen, John C, Randell, Scott H, Stripp, Barry R, Tata, Purushothama Rao, O'Neal, Wanda K, Boucher, Richard C
Published in American journal of respiratory and critical care medicine (15.05.2021)
Published in American journal of respiratory and critical care medicine (15.05.2021)
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Assessing Human Airway Epithelial Progenitor Cells for Cystic Fibrosis Cell Therapy
Lee, Rhianna E, Miller, Sean M, Mascenik, Teresa M, Lewis, Catherine A, Dang, Hong, Boggs, Zachary H, Tarran, Robert, Randell, Scott H
Published in American journal of respiratory cell and molecular biology (01.09.2020)
Published in American journal of respiratory cell and molecular biology (01.09.2020)
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A MERS-CoV antibody neutralizes a pre-emerging group 2c bat coronavirus
Tse, Longping V, Hou, Yixuan J, McFadden, Elizabeth, Lee, Rhianna E, Scobey, Trevor D, Leist, Sarah R, Martinez, David R, Meganck, Rita M, Schäfer, Alexandra, Yount, Boyd L, Mascenik, Teresa, Powers, John M, Randell, Scott H, Zhang, Yi, Wang, Lingshu, Mascola, John, McLellan, Jason S, Baric, Ralph S
Published in Science translational medicine (27.09.2023)
Published in Science translational medicine (27.09.2023)
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Viral airway injury promotes cell engraftment in an in vitro model of cystic fibrosis cell therapy
Lee, Rhianna E, Mascenik, Teresa M, Major, Sidra C, Galiger, Jacob R, Bulik-Sullivan, Emily, Siesser, Priscila F, Lewis, Catherine A, Bear, James E, Le Suer, Jake A, Hawkins, Finn J, Pickles, Raymond J, Randell, Scott H
Published in American journal of physiology. Lung cellular and molecular physiology (01.03.2024)
Published in American journal of physiology. Lung cellular and molecular physiology (01.03.2024)
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Epigenome editing of the CFTR-locus for treatment of cystic fibrosis
Kabadi, Ami M., Machlin, Leah, Dalal, Nikita, Lee, Rhianna E., McDowell, Ian, Shah, Nirav N., Drowley, Lauren, Randell, Scott H., Reddy, Timothy E.
Published in Journal of cystic fibrosis (01.01.2022)
Published in Journal of cystic fibrosis (01.01.2022)
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Host range, transmissibility and antigenicity of a pangolin coronavirus
Hou, Yixuan J, Chiba, Shiho, Leist, Sarah R, Meganck, Rita M, Martinez, David R, Schäfer, Alexandra, Catanzaro, Nicholas J, Sontake, Vishwaraj, West, Ande, Edwards, Catlin E, Yount, Boyd, Lee, Rhianna E, Gallant, Samuel C, Zost, Seth J, Powers, John, Adams, Lily, Kong, Edgar F, Mattocks, Melissa, Tata, Aleksandra, Randell, Scott H, Tata, Purushothama R, Halfmann, Peter, Crowe, James E, Kawaoka, Yoshihiro, Baric, Ralph S
Published in Nature microbiology (01.10.2023)
Published in Nature microbiology (01.10.2023)
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Mometasone absorption in cultured airway epithelium
Nguyen, Tuong T., Soma, Paul S., Mascenik, Teresa, Lewis, Catherine A., Lee, Rhianna E., Thorp, Brian D., Zanation, Adam M., Ebert, Charles S., Senior, Brent A., Randell, Scott H., Ehrmann, Brandie M., Kimple, Adam J.
Published in International forum of allergy & rhinology (01.12.2019)
Published in International forum of allergy & rhinology (01.12.2019)
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Journal Article
SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo
Hou, Yixuan J, Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, 3rd, Kenneth H, Leist, Sarah R, Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E, Mascenik, Teresa M, Edwards, Caitlin E, Tse, Longping V, Boucher, Richard C, Randell, Scott H, Suzuki, Tadaki, Gralinski, Lisa E, Kawaoka, Yoshihiro, Baric, Ralph S
Published in bioRxiv (29.09.2020)
Published in bioRxiv (29.09.2020)
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Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough
Lee, Rhianna E, Lewis, Catherine A, He, Lihua, Bulik-Sullivan, Emily C, Gallant, Samuel C, Mascenik, Teresa M, Dang, Hong, Cholon, Deborah M, Gentzsch, Martina, Morton, Lisa C, Minges, John T, Theile, Jonathan W, Castle, Neil A, Knowles, Michael R, Kimple, Adam J, Randell, Scott H
Published in The Journal of clinical investigation (01.09.2022)
Published in The Journal of clinical investigation (01.09.2022)
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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
Hou, Yixuan J., Okuda, Kenichi, Edwards, Caitlin E., Martinez, David R., Asakura, Takanori, Dinnon, Kenneth H., Kato, Takafumi, Lee, Rhianna E., Yount, Boyd L., Mascenik, Teresa M., Chen, Gang, Olivier, Kenneth N., Ghio, Andrew, Tse, Longping V., Leist, Sarah R., Gralinski, Lisa E., Schäfer, Alexandra, Dang, Hong, Gilmore, Rodney, Nakano, Satoko, Sun, Ling, Fulcher, M. Leslie, Livraghi-Butrico, Alessandra, Nicely, Nathan I., Cameron, Mark, Cameron, Cheryl, Kelvin, David J., de Silva, Aravinda, Margolis, David M., Markmann, Alena, Bartelt, Luther, Zumwalt, Ross, Martinez, Fernando J., Salvatore, Steven P., Borczuk, Alain, Tata, Purushothama R., Sontake, Vishwaraj, Kimple, Adam, Jaspers, Ilona, O’Neal, Wanda K., Randell, Scott H., Boucher, Richard C., Baric, Ralph S.
Published in Cell (23.07.2020)
Published in Cell (23.07.2020)
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K978C CFTR restores essential epithelial function with greater efficiency than wildtype CFTR when expressed in CF airway cells
Woodall, Maximillian N J, Tarran, Robert, Lee, Rhianna E, Anfishi, Hafssa, Prins, Stella, Counsell, John, Vergani, Paola, Hart, Stephen L, Baines, Deborah
Published in bioRxiv (13.08.2022)
Published in bioRxiv (13.08.2022)
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Robust W1282X-CFTR rescue by a small molecule GSPT1 degrader
Lee, Rhianna E, Lewis, Catherine A, He, Lihua, Gallant, Samuel C, Mascenik, Teresa M, Dang, Hong, Morton, Lisa C, Minges, John T, Theile, Jonathan W, Castle, Neil A, Knowles, Michael R, Kimple, Adam J, Randell, Scott H
Published in bioRxiv (30.09.2021)
Published in bioRxiv (30.09.2021)
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