GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In Vivo
WALLIN, Jeffrey J, GUAN, Jane, PRIOR, Wei Wei, LEE, Leslie B, BERRY, Leanne, BELMONT, Lisa D, KOEPPEN, Hartmut, BELVIN, Marcia, FRIEDMAN, Lori S, SAMPATH, Deepak
Published in Clinical cancer research (15.07.2012)
Published in Clinical cancer research (15.07.2012)
Get full text
Journal Article
Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis
Abdollahi, Amir, Li, Minglun, Ping, Gong, Plathow, Christian, Domhan, Sophie, Kiessling, Fabian, Lee, Leslie B, McMahon, Gerald, Gröne, Hermann-Josef, Lipson, Kenneth E, Huber, Peter E
Published in The Journal of experimental medicine (21.03.2005)
Published in The Journal of experimental medicine (21.03.2005)
Get full text
Journal Article
Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1 -Deficient Tumor Models
O'Brien, Thomas, Oeh, Jason, Xiao, Yang, Liang, Xiaorong, Vanderbilt, Alexander, Qin, Ann, Yang, Lulu, Lee, Leslie B, Ly, Justin, Cosino, Ely, LaCap, Jennifer A, Ogasawara, Annie, Williams, Simon, Nannini, Michelle, Liederer, Bianca M, Jackson, Peter, Dragovich, Peter S, Sampath, Deepak
Published in Neoplasia (New York, N.Y.) (01.12.2013)
Published in Neoplasia (New York, N.Y.) (01.12.2013)
Get full text
Journal Article
Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with “standard of care” therapeutic agents for the treatment of breast cancer
Abrams, Tinya J, Murray, Lesley J, Pesenti, Enrico, Holway, Vicky Walker, Colombo, Tina, Lee, Leslie B, Cherrington, Julie M, Pryer, Nancy K
Published in Molecular cancer therapeutics (01.10.2003)
Get full text
Published in Molecular cancer therapeutics (01.10.2003)
Journal Article
Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models
JIE LIN, SAMPATH, Deepak, LEE, Leslie B, RISOM, Tyler, GROSS, Stefan, LIEDERER, Bianca M, KOEPPEN, Hartmut, SKELTON, Nicholas J, WALLIN, Jeffrey J, BELVIN, Marcia, PUNNOOSE, Elizabeth, FRIEDMAN, Lori S, NANNINI, Michelle A, KUI LIN, LEE, Brian B, DEGTYAREV, Michael, OEH, Jason, SAVAGE, Heidi, ZHENGYU GUAN, HONG, Rebecca, KASSEES, Robert
Published in Clinical cancer research (01.04.2013)
Published in Clinical cancer research (01.04.2013)
Get full text
Journal Article
Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia
Dail, Monique, Wong, Jason, Lawrence, Jessica, O'Connor, Daniel, Nakitandwe, Joy, Chen, Shann-Ching, Xu, Jin, Lee, Leslie B, Akagi, Keiko, Li, Qing, Aster, Jon C, Pear, Warren S, Downing, James R, Sampath, Deepak, Shannon, Kevin
Published in Nature (London) (25.09.2014)
Published in Nature (London) (25.09.2014)
Get full text
Journal Article
Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors
EDGAR, Kyle A, WALLIN, Jeffrey J, BERRY, Megan, LEE, Leslie B, PRIOR, Wei Wei, SAMPATH, Deepak, FRIEDMAN, Lori S, BELVIN, Marcia
Published in Cancer research (Chicago, Ill.) (01.02.2010)
Published in Cancer research (Chicago, Ill.) (01.02.2010)
Get full text
Journal Article
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Heffron, Timothy P, Ndubaku, Chudi O, Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Drobnick, Joy, Edgar, Kyle, Gould, Stephen E, Lee, Leslie B, Lesnick, John D, Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Plise, Emile G, Sideris, Steve, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin, Olivero, Alan G
Published in ACS medicinal chemistry letters (14.04.2016)
Published in ACS medicinal chemistry letters (14.04.2016)
Get full text
Journal Article
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma
Salphati, Laurent, Alicke, Bruno, Heffron, Timothy P, Shahidi-Latham, Sheerin, Nishimura, Merry, Cao, Tim, Carano, Richard A, Cheong, Jonathan, Greve, Joan, Koeppen, Hartmut, Lau, Shari, Lee, Leslie B, Nannini-Pepe, Michelle, Pang, Jodie, Plise, Emile G, Quiason, Cristine, Rangell, Linda, Zhang, Xiaolin, Gould, Stephen E, Phillips, Heidi S, Olivero, Alan G
Published in Drug metabolism and disposition (01.12.2016)
Published in Drug metabolism and disposition (01.12.2016)
Get full text
Journal Article
Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models
Tan, Nguyen, Wong, Maureen, Nannini, Michelle A, Hong, Rebecca, Lee, Leslie B, Price, Stephen, Williams, Karen, Savy, Pierre Pascal, Yue, Peng, Sampath, Deepak, Settleman, Jeffrey, Fairbrother, Wayne J, Belmont, Lisa D
Published in Molecular cancer therapeutics (01.06.2013)
Published in Molecular cancer therapeutics (01.06.2013)
Get full text
Journal Article
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
MENDEL, Dirk B, LAIRD, A. Douglas, MURRAY, Lesley J, CARVER, Jeremy, CHAN, Emily, MOSS, Katherine G, HAZNEDAR, Joshua Ö, SUKBUNTHERNG, Juthamas, BLAKE, Robert A, LI SUN, CHO TANG, MILLER, Todd, XIAOHUA XIN, SHIRAZIAN, Sheri, MCMAHON, Gerald, CHERRINGTON, Julie M, LOUIE, Sharianne G, CHRISTENSEN, James G, GUANGMIN LI, SCHRECK, Randall E, ABRAMS, Tinya J, NGAI, Theresa J, LEE, Leslie B
Published in Clinical cancer research (2003)
Get full text
Published in Clinical cancer research (2003)
Journal Article
SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
O'Farrell, Anne-Marie, Abrams, Tinya J., Yuen, Helene A., Ngai, Theresa J., Louie, Sharianne G., Yee, Kevin W.H., Wong, Lily M., Hong, Weiru, Lee, Leslie B., Town, Ajia, Smolich, Beverly D., Manning, William C., Murray, Lesley J., Heinrich, Michael C., Cherrington, Julie M.
Published in Blood (01.05.2003)
Published in Blood (01.05.2003)
Get full text
Journal Article
The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3‑Kinase α
Heffron, Timothy P, Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Dotson, Jennafer, Edgar, Kyle, Goldsmith, Richard, Gould, Stephen E, Lee, Leslie B, Lesnick, John D, Lewis, Cristina, Ndubaku, Chudi, Nonomiya, Jim, Olivero, Alan G, Pang, Jodie, Plise, Emile G, Sideris, Steve, Trapp, Sean, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin
Published in Journal of medicinal chemistry (27.09.2012)
Published in Journal of medicinal chemistry (27.09.2012)
Get full text
Journal Article
Targeting the PI3K Pathway in the Brain-Efficacy of a PI3K Inhibitor Optimized to Cross the Blood―Brain Barrier
SALPHATI, Laurent, HEFFRON, Timothy P, KOEPPEN, Hartmut, LAU, Shari, LEE, Leslie B, PANG, Jodie, PLISE, Emile G, POKORNY, Jenny L, BOU RESLAN, Hani, SARKARIA, Jann N, WALLIN, Jeffrey J, XIAOLIN ZHANG, ALICKE, Bruno, GOULD, Stephen E, OLIVERO, Alan G, PHILLIPS, Heidi S, NISHIMURA, Merry, BARCK, Kai, CARANO, Richard A, CHEONG, Jonathan, EDGAR, Kyle A, GREVE, Joan, KHARBANDA, Samir
Published in Clinical cancer research (15.11.2012)
Published in Clinical cancer research (15.11.2012)
Get full text
Journal Article
Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human
Salphati, Laurent, Pang, Jodie, Plise, Emile G, Lee, Leslie B, Olivero, Alan G, Prior, Wei Wei, Sampath, Deepak, Wong, Susan, Zhang, Xiaolin
Published in Drug metabolism and disposition (01.09.2012)
Published in Drug metabolism and disposition (01.09.2012)
Get full text
Journal Article
Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941
Salphati, Laurent, Lee, Leslie B, Pang, Jodie, Plise, Emile G, Zhang, Xiaolin
Published in Drug metabolism and disposition (01.09.2010)
Published in Drug metabolism and disposition (01.09.2010)
Get full text
Journal Article
Loss of oncogenic notchl with resistance to a PI3K inhibitor in t-cell leukaemia
Dail, Monique, Wong, Jason, Lawrence, Jessica, O'Connor, Daniel, Nakitandwe, Joy, Chen, Shann-Ching, Xu, Jin, Lee, Leslie B, Akagi, Keiko, Li, Qing, Aster, Jon C, Pear, Warren S, Downing, James R, Sampath, Deepak, Shannon, Kevin
Published in Nature (London) (25.09.2014)
Published in Nature (London) (25.09.2014)
Get full text
Journal Article
Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models1
O'Brien, Thomas, Oeh, Jason, Xiao, Yang, Liang, Xiaorong, Vanderbilt, Alexander, Qin, Ann, Yang, Lulu, Lee, Leslie B, Ly, Justin, Cosino, Ely, LaCap, Jennifer A, Ogasawara, Annie, Williams, Simon, Nannini, Michelle, Liederer, Bianca M, Jackson, Peter, Dragovich, Peter S, Sampath, Deepak
Published in Neoplasia (New York, N.Y.) (01.12.2013)
Get full text
Published in Neoplasia (New York, N.Y.) (01.12.2013)
Journal Article