Modern Phenotypic Drug Discovery Is a Viable, Neoclassic Pharma Strategy
Lee, Jonathan A, Uhlik, Mark T, Moxham, Christopher M, Tomandl, Dirk, Sall, Daniel J
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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Journal Article
Opportunities and challenges in phenotypic drug discovery: an industry perspective
Moffat, John G., Vincent, Fabien, Lee, Jonathan A., Eder, Jörg, Prunotto, Marco
Published in Nature reviews. Drug discovery (01.08.2017)
Published in Nature reviews. Drug discovery (01.08.2017)
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Journal Article
Polymeric Cross-Linked Surface Treatments for Controlling Block Copolymer Orientation in Thin Films
Bates, Christopher M, Strahan, Jeffrey R, Santos, Logan J, Mueller, Brennen K, Bamgbade, Benjamin O, Lee, Jonathan A, Katzenstein, Joshua M, Ellison, Christopher J, Willson, C. Grant
Published in Langmuir (01.03.2011)
Published in Langmuir (01.03.2011)
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A quantitative, facile, and high-throughput image-based cell migration method is a robust alternative to the scratch assay
Gough, Wendy, Hulkower, Keren I, Lynch, Renee, McGlynn, Patrick, Uhlik, Mark, Yan, Lei, Lee, Jonathan A
Published in Journal of biomolecular screening (01.02.2011)
Published in Journal of biomolecular screening (01.02.2011)
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Journal Article
Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays
Lee, Jonathan A, Shinn, Paul, Jaken, Susan, Oliver, Sarah, Willard, Francis S, Heidler, Steven, Peery, Robert B, Oler, Jennifer, Chu, Shaoyou, Southall, Noel, Dexheimer, Thomas S, Smallwood, Jeffrey, Huang, Ruili, Guha, Rajarshi, Jadhav, Ajit, Cox, Karen, Austin, Christopher P, Simeonov, Anton, Sittampalam, G Sitta, Husain, Saba, Franklin, Natalie, Wild, David J, Yang, Jeremy J, Sutherland, Jeffrey J, Thomas, Craig J
Published in PloS one (15.07.2015)
Published in PloS one (15.07.2015)
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Journal Article
An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors
Falcon, Beverly L, Swearingen, Michelle, Gough, Wendy H, Lee, Linda, Foreman, Robert, Uhlik, Mark, Hanson, Jeff C, Lee, Jonathan A, McClure, Don B, Chintharlapalli, Sudhakar
Published in PloS one (11.09.2014)
Published in PloS one (11.09.2014)
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Journal Article
Nuisance compounds in cellular assays
Dahlin, Jayme L., Auld, Douglas S., Rothenaigner, Ina, Haney, Steve, Sexton, Jonathan Z., Nissink, J. Willem M., Walsh, Jarrod, Lee, Jonathan A., Strelow, John M., Willard, Francis S., Ferrins, Lori, Baell, Jonathan B., Walters, Michael A., Hua, Bruce K., Hadian, Kamyar, Wagner, Bridget K.
Published in Cell chemical biology (18.03.2021)
Published in Cell chemical biology (18.03.2021)
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Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data
Xu, David, Zhou, Donghui, Bum-Erdene, Khuchtumur, Bailey, Barbara J, Sishtla, Kamakshi, Liu, Sheng, Wan, Jun, Aryal, Uma K, Lee, Jonathan A, Wells, Clark D, Fishel, Melissa L, Corson, Timothy W, Pollok, Karen E, Meroueh, Samy O
Published in ACS chemical biology (19.06.2020)
Published in ACS chemical biology (19.06.2020)
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Journal Article
Empirical drug discovery: a view from the proteome
Lee, Jonathan A., Carragher, Neil O., Berg, Ellen L.
Published in Drug discovery today. Technologies (01.03.2017)
Published in Drug discovery today. Technologies (01.03.2017)
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Journal Article
Open innovation for phenotypic drug discovery: The PD2 assay panel
Lee, Jonathan A, Chu, Shaoyou, Willard, Francis S, Cox, Karen L, Sells Galvin, Rachelle J, Peery, Robert B, Oliver, Sarah E, Oler, Jennifer, Meredith, Tamika D, Heidler, Steven A, Gough, Wendy H, Husain, Saba, Palkowitz, Alan D, Moxham, Christopher M
Published in Journal of biomolecular screening (01.07.2011)
Published in Journal of biomolecular screening (01.07.2011)
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Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor
Richardson, Timothy I, Ornstein, Paul L, Briner, Karin, Fisher, Matthew J, Backer, Ryan T, Biggers, C. Kelly, Clay, Michael P, Emmerson, Paul J, Hertel, Larry W, Hsiung, Hansen M, Husain, Saba, Kahl, Steven D, Lee, Jonathan A, Lindstrom, Terry D, Martinelli, Michael J, Mayer, John P, Mullaney, Jeffery T, O'Brien, Thomas P, Pawlak, Joseph M, Revell, Kevin D, Shah, Jikesh, Zgombick, John M, Herr, R. Jason, Melekhov, Alex, Sampson, Peter B, King, Chi-Hsin R
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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Journal Article
Lysine 182 of Endothelin B Receptor Modulates Agonist Selectivity and Antagonist Affinity: Evidence for the Overlap of Peptide and Non-peptide Ligand Binding Sites
Lee, Jonathan A, Brinkmann, Joyce A, Longton, Enrique D, Peishoff, Catherine E, Lago, M. Amparo, Leber, Jack D, Cousins, Russell D, Gao, Aiming, Stadel, Jeffrey M
Published in Biochemistry (Easton) (06.12.1994)
Published in Biochemistry (Easton) (06.12.1994)
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Abstract 1612: Overexpression or inducible expression of Snail, Zeb1 or TGFβ recapitulates epithelial-mesenchymal transition (EMT) in colorectal cancer cell lines in vitro
Bhagwat, Shripad V., Hamm, Nicole E., Hsu, Yu-Chih, Qian, Yuewei, Wild, Robert, Lee, Jonathan A., Peng, Sheng-Bin
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Tyr-129 is Important to the Peptide Ligand Affinity and Selectivity of Human Endothelin Type A Receptor
Lee, Jonathan A., Elliott, John D., Sutiphong, Joyce A., Friesen, Westley J., Ohlstein, Eliot H., Stadel, Jeffrey M., Gleason, John G., Peishoff, Catherine E.
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.1994)
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Journal Article
Characterization of site-directed mutants in the lac permease of Escherichia coli. 2. Glutamate-325 replacements
Carrasco, Nancy, Puttner, Irene B, Antes, Lisa M, Lee, Jonathan A, Larigan, J. Douglas, Lolkema, Julius S, Roepe, Paul D, Kaback, H. Ronald
Published in Biochemistry (Easton) (01.03.1989)
Published in Biochemistry (Easton) (01.03.1989)
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