LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
Bae, Eun-Jin, Kim, Dong-Kyu, Kim, Changyoun, Mante, Michael, Adame, Anthony, Rockenstein, Edward, Ulusoy, Ayse, Klinkenberg, Michael, Jeong, Ga Ram, Bae, Jae Ryul, Lee, Cheolsoon, Lee, He-Jin, Lee, Byung-Dae, Di Monte, Donato A., Masliah, Eliezer, Lee, Seung-Jae
Published in Nature communications (27.08.2018)
Published in Nature communications (27.08.2018)
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Journal Article
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation
Kim, Changyoun, Spencer, Brian, Rockenstein, Edward, Yamakado, Hodaka, Mante, Michael, Adame, Anthony, Fields, Jerel Adam, Masliah, Deborah, Iba, Michiyo, Lee, He-Jin, Rissman, Robert A, Lee, Seung-Jae, Masliah, Eliezer
Published in Molecular neurodegeneration (09.08.2018)
Published in Molecular neurodegeneration (09.08.2018)
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Journal Article
Senescence and impaired DNA damage responses in alpha-synucleinopathy models
Yoon, Ye-Seul, You, Jueng Soo, Kim, Tae-Kyung, Ahn, Woo Jung, Kim, Myoung Jun, Son, Keun Hong, Ricarte, Diadem, Ortiz, Darlene, Lee, Seung-Jae, Lee, He-Jin
Published in Experimental & molecular medicine (01.02.2022)
Published in Experimental & molecular medicine (01.02.2022)
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Journal Article
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
Desplats, Paula, Lee, He-Jin, Bae, Eun-Jin, Patrick, Christina, Rockenstein, Edward, Crews, Leslie, Spencer, Brian, Masliah, Eliezer, Lee, Seung-Jae
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
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Journal Article
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
Kim, Changyoun, Rockenstein, Edward, Spencer, Brian, Kim, Hyung-Koo, Adame, Anthony, Trejo, Margarita, Stafa, Klodjan, Lee, He-Jin, Lee, Seung-Jae, Masliah, Eliezer
Published in Cell reports (Cambridge) (27.10.2015)
Published in Cell reports (Cambridge) (27.10.2015)
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Journal Article
Models of multiple system atrophy
Lee, He-Jin, Ricarte, Diadem, Ortiz, Darlene, Lee, Seung-Jae
Published in Experimental & molecular medicine (18.11.2019)
Published in Experimental & molecular medicine (18.11.2019)
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Journal Article
Inflammation promotes synucleinopathy propagation
Kim, Tae-Kyung, Bae, Eun-Jin, Jung, Byung Chul, Choi, Minsun, Shin, Soo Jean, Park, Sung Jun, Kim, Jeong Tae, Jung, Min Kyo, Ulusoy, Ayse, Song, Mi-Young, Lee, Jun Sung, Lee, He-Jin, Di Monte, Donato A., Lee, Seung-Jae
Published in Experimental & molecular medicine (01.12.2022)
Published in Experimental & molecular medicine (01.12.2022)
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Journal Article
Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function
Kim, Dong-Kyu, Lim, Hee-Sun, Kawasaki, Ichiro, Shim, Yhong-Hee, Vaikath, Nishant N., El-Agnaf, Omar M. A., Lee, He-Jin, Lee, Seung-Jae
Published in Autophagy (02.10.2016)
Published in Autophagy (02.10.2016)
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Journal Article
Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection
Lee, He-Jin, Kim, Changyoun, Lee, Seung-Jae
Published in Oxidative medicine and cellular longevity (01.07.2010)
Published in Oxidative medicine and cellular longevity (01.07.2010)
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Journal Article
Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation
Yoon, Ye-Seul, Cho, Eun-Duk, Jung Ahn, Woo, Won Lee, Kyung, Lee, Seung-Jae, Lee, He-Jin
Published in Cell death & disease (05.10.2017)
Published in Cell death & disease (05.10.2017)
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Journal Article
Impairment of microtubule-dependent trafficking by overexpression of α-synuclein
Lee, He-Jin, Khoshaghideh, Farnaz, Lee, Stephen, Lee, Seung-Jae
Published in The European journal of neuroscience (01.12.2006)
Published in The European journal of neuroscience (01.12.2006)
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Journal Article
Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives
Lee, Seung-Jae, Lim, Hee-Sun, Masliah, Eliezer, Lee, He-Jin
Published in Neuroscience research (01.08.2011)
Published in Neuroscience research (01.08.2011)
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Journal Article
Glucocerebrosidase, a new player changing the old rules in Lewy body diseases
Yang, Na-Young, Lee, Yu-Na, Lee, He-Jin, Kim, Yoon Suk, Lee, Seung-Jae
Published in Biological chemistry (01.07.2013)
Published in Biological chemistry (01.07.2013)
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Journal Article
Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
Lee, He-Jin, Suk, Ji-Eun, Patrick, Christina, Bae, Eun-Jin, Cho, Ji-Hoon, Rho, Sangchul, Hwang, Daehee, Masliah, Eliezer, Lee, Seung-Jae
Published in The Journal of biological chemistry (19.03.2010)
Published in The Journal of biological chemistry (19.03.2010)
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Journal Article
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
Kim, Changyoun, Ho, Dong-Hwan, Suk, Ji-Eun, You, Sungyong, Michael, Sarah, Kang, Junghee, Joong Lee, Sung, Masliah, Eliezer, Hwang, Daehee, Lee, He-Jin, Lee, Seung-Jae
Published in Nature communications (2013)
Published in Nature communications (2013)
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Journal Article