Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
Lee, Edmund C, Valencia, Tania, Allerson, Charles, Schairer, Annelie, Flaten, Andrea, Yheskel, Matanel, Kersjes, Kara, Li, Jian, Gatto, Sole, Takhar, Mandeep, Lockton, Steven, Pavlicek, Adam, Kim, Michael, Chu, Tiffany, Soriano, Randy, Davis, Scott, Androsavich, John R, Sarwary, Salma, Owen, Tate, Kaplan, Julia, Liu, Kai, Jang, Graham, Neben, Steven, Bentley, Philip, Wright, Timothy, Patel, Vishal
Published in Nature communications (12.09.2019)
Published in Nature communications (12.09.2019)
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PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression
Lakhia, Ronak, Ramalingam, Harini, Chang, Chun-Mien, Cobo-Stark, Patricia, Biggers, Laurence, Flaten, Andrea, Alvarez, Jesus, Valencia, Tania, Wallace, Darren P, Lee, Edmund C, Patel, Vishal
Published in Nature communications (15.08.2022)
Published in Nature communications (15.08.2022)
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microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
Hajarnis, Sachin, Lakhia, Ronak, Yheskel, Matanel, Williams, Darren, Sorourian, Mehran, Liu, Xueqing, Aboudehen, Karam, Zhang, Shanrong, Kersjes, Kara, Galasso, Ryan, Li, Jian, Kaimal, Vivek, Lockton, Steven, Davis, Scott, Flaten, Andrea, Johnson, Joshua A, Holland, William L, Kusminski, Christine M, Scherer, Philipp E, Harris, Peter C, Trudel, Marie, Wallace, Darren P, Igarashi, Peter, Lee, Edmund C, Androsavich, John R, Patel, Vishal
Published in Nature communications (16.02.2017)
Published in Nature communications (16.02.2017)
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Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer
KUPPERMAN, Erik, LEE, Edmund C, BLANK, Jonathan, GARCIA, Khristofer, TSU, Christopher, DICK, Larry, FLEMING, Paul, LI YU, MANFREDI, Mark, ROLFE, Mark, BOLEN, Joe, YUEYING CAO, BANNERMAN, Bret, FITZGERALD, Michael, BERGER, Allison, JIE YU, YU YANG, BRUZZESE, Frank, LIU, Jane
Published in Cancer research (Chicago, Ill.) (01.03.2010)
Published in Cancer research (Chicago, Ill.) (01.03.2010)
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Antitumor Activity of the Investigational Proteasome Inhibitor MLN9708 in Mouse Models of B-cell and Plasma Cell Malignancies
LEE, Edmund C, FITZGERALD, Michael, PICKARD, Michael, ZHI LI, TAYBER, Olga, PING LI, HALES, Paul, CARSILLO, Mary, NEPPALLI, Vishala T, BERGER, Allison J, KUPPERMAN, Erik, MANFREDI, Mark, BANNERMAN, Bret, BOLEN, Joseph B, NESS, Brian Van, JANZ, Siegfried, DONELAN, Jill, BANO, Kristen, TERKELSEN, Jennifer, BRADLEY, Daniel P, SUBAKAN, Ozlem, SILVA, Matthew D, LIU, Ray
Published in Clinical cancer research (01.12.2011)
Published in Clinical cancer research (01.12.2011)
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Pharmacokinetics and Absorption, Distribution, Metabolism and Excretion of RGLS4326 in Mouse and Monkey, an Anti–miR-17 Oligonucleotide for the Treatment of Polycystic Kidney Disease
Kamel, Amin, Owen, Tate, Cole, Izaiah, Valencia, Tania, Lee, Edmund C.
Published in Drug metabolism and disposition (01.11.2023)
Published in Drug metabolism and disposition (01.11.2023)
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Lipid Nanoparticle-Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth
Huang, Xinqiang, Magnus, Jill, Kaimal, Vivek, Karmali, Priya, Li, Jian, Walls, Marlena, Prudente, Rene, Sung, Eric, Sorourian, Mehran, Lee, Robin, Davis, Scott, Yang, Xia, Estrella, Heather, Lee, Edmund C, Chau, B Nelson, Pavlicek, Adam, Zabludoff, Sonya
Published in Molecular cancer therapeutics (01.05.2017)
Published in Molecular cancer therapeutics (01.05.2017)
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Optimization of Benzodiazepinones as Selective Inhibitors of the X‑Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain
Kester, Robert F, Donnell, Andrew F, Lou, Yan, Remiszewski, Stacy W, Lombardo, Louis J, Chen, Shaoqing, Le, Nam T, Lo, Jennifer, Moliterni, John A, Han, Xiaochun, Hogg, J. Heather, Liang, Weiling, Michoud, Christophe, Rupert, Kenneth C, Mischke, Steven, Le, Kang, Weisel, Martin, Janson, Cheryl A, Lukacs, Christine M, Fretland, Adrian J, Hong, Kyoungja, Polonskaia, Ann, Gao, Lin, Li, Shirley, Solis, Dave S, Aguilar, Doug, Tardell, Christine, Dvorozniak, Mark, Tannu, Shahid, Lee, Edmund C, Schutt, Andy D, Goggin, Barry
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Abstract 1459: miR-221: A potential therapeutic target for hepatocellular carcinoma
Lee, Edmund C., Xu, Jessica, Vincent, Thomas, Chen, Jie, Nelson, Michael, Huang, Xinqiang, Marcusson, Eric, Androsavich, John, Davis, Scott, Pavlicek, Adam, Gibson, Neil, Zabludoff, Sonya
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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