2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1
Blanchard, Stéphanie, Soh, Chang Kai, Lee, Chai Ping, Poulsen, Anders, Bonday, Zahid, Goh, Kay Lin, Goh, Kee Chuan, Goh, Miah Kiat, Pasha, Mohammed Khalid, Wang, Haishan, Williams, Meredith, Wood, Jeanette M., Ethirajulu, Kantharaj, Dymock, Brian W.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer
William, Anthony D, Lee, Angeline C.-H, Goh, Kee Chuan, Blanchard, Stéphanie, Poulsen, Anders, Teo, Ee Ling, Nagaraj, Harish, Lee, Chai Ping, Wang, Haishan, Williams, Meredith, Sun, Eric T, Hu, Changyong, Jayaraman, Ramesh, Pasha, Mohammed Khalid, Ethirajulu, Kantharaj, Wood, Jeanette M, Dymock, Brian W
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
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Discovery of the Macrocycle (9E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a Potent Inhibitor of Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) for the Treatment of Rheumatoid Arthritis
William, Anthony D, Lee, Angeline C.-H, Poulsen, Anders, Goh, Kee Chuan, Madan, Babita, Hart, Stefan, Tan, Evelyn, Wang, Haishan, Nagaraj, Harish, Chen, Dizhong, Lee, Chai Ping, Sun, Eric T, Jayaraman, Ramesh, Pasha, Mohammad Khalid, Ethirajulu, Kantharaj, Wood, Jeanette M, Dymock, Brian W
Published in Journal of medicinal chemistry (22.03.2012)
Published in Journal of medicinal chemistry (22.03.2012)
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Journal Article
Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritis
William, Anthony D, Lee, Angeline C-H, Poulsen, Anders, Goh, Kee Chuan, Madan, Babita, Hart, Stefan, Tan, Evelyn, Wang, Haishan, Nagaraj, Harish, Chen, Dizhong, Lee, Chai Ping, Sun, Eric T, Jayaraman, Ramesh, Pasha, Mohammad Khalid, Ethirajulu, Kantharaj, Wood, Jeanette M, Dymock, Brian W
Published in Journal of medicinal chemistry (22.03.2012)
Published in Journal of medicinal chemistry (22.03.2012)
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Journal Article