Mechanisms of resistance to EGFR targeted therapies
Hrustanovic, Gorjan, Lee, Bianca J., Bivona, Trever G.
Published in Cancer biology & therapy (01.04.2013)
Published in Cancer biology & therapy (01.04.2013)
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Journal Article
Efficacy of a Novel Bi-Steric mTORC1 Inhibitor in Models of B-Cell Acute Lymphoblastic Leukemia
Lee, Bianca J., Mallya, Sharmila, Dinglasan, Nuntana, Fung, Amos, Nguyen, Tram, Herzog, Lee-or, Thao, Joshua, Lorenzana, Edward G., Wildes, David, Singh, Mallika, Smith, Jacqueline A. M., Fruman, David A.
Published in Frontiers in oncology (02.08.2021)
Published in Frontiers in oncology (02.08.2021)
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Journal Article
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Holderfield, Matthew, Lee, Bianca J., Jiang, Jingjing, Tomlinson, Aidan, Seamon, Kyle J., Mira, Alessia, Patrucco, Enrico, Goodhart, Grace, Dilly, Julien, Gindin, Yevgeniy, Dinglasan, Nuntana, Wang, Yingyun, Lai, Lick Pui, Cai, Shurui, Jiang, Lingyan, Nasholm, Nicole, Shifrin, Nataliya, Blaj, Cristina, Shah, Harshit, Evans, James W., Montazer, Nilufar, Lai, Oliver, Shi, Jade, Ahler, Ethan, Quintana, Elsa, Chang, Stephanie, Salvador, Anthony, Marquez, Abby, Cregg, Jim, Liu, Yang, Milin, Anthony, Chen, Anqi, Ziv, Tamar Bar, Parsons, Dylan, Knox, John E., Klomp, Jennifer E., Roth, Jennifer, Rees, Matthew, Ronan, Melissa, Cuevas-Navarro, Antonio, Hu, Feng, Lito, Piro, Santamaria, David, Aguirre, Andrew J., Waters, Andrew M., Der, Channing J., Ambrogio, Chiara, Wang, Zhengping, Gill, Adrian L., Koltun, Elena S., Smith, Jacqueline A. M., Wildes, David, Singh, Mallika
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
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Journal Article
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
Burnett, G. Leslie, Yang, Yu C., Aggen, James B., Pitzen, Jennifer, Gliedt, Micah K., Semko, Chris M., Marquez, Abby, Evans, James W., Wang, Gang, Won, Walter S., Tomlinson, Aidan C. A., Kiss, Gert, Tzitzilonis, Christos, Thottumkara, Arun P., Cregg, James, Mellem, Kevin T., Choi, Jong S., Lee, Julie C., Zhao, Yongyuan, Lee, Bianca J., Meyerowitz, Justin G., Knox, John E., Jiang, Jingjing, Wang, Zhican, Wildes, David, Wang, Zhengping, Singh, Mallika, Smith, Jacqueline A. M., Gill, Adrian L.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Journal Article
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal
Published in Nature chemical biology (01.10.2021)
Published in Nature chemical biology (01.10.2021)
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Journal Article
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Jiang, Jingjing, Jiang, Lingyan, Maldonato, Benjamin J, Wang, Yingyun, Holderfield, Matthew, Aronchik, Ida, Winters, Ian P, Salman, Zeena, Blaj, Cristina, Menard, Marie, Brodbeck, Jens, Chen, Zhe, Wei, Xing, Rosen, Michael J, Gindin, Yevgeniy, Lee, Bianca J, Evans, James W, Chang, Stephanie, Wang, Zhican, Seamon, Kyle J, Parsons, Dylan, Cregg, James, Marquez, Abby, Tomlinson, Aidan C A, Yano, Jason K, Knox, John E, Quintana, Elsa, Aguirre, Andrew J, Arbour, Kathryn C, Reed, Abby, Gustafson, W Clay, Gill, Adrian L, Koltun, Elena S, Wildes, David, Smith, Jacqueline A M, Wang, Zhengping, Singh, Mallika
Published in Cancer discovery (09.04.2024)
Published in Cancer discovery (09.04.2024)
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Journal Article
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal
Published in Nature chemical biology (01.08.2021)
Published in Nature chemical biology (01.08.2021)
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Journal Article
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal
Published in Nature chemical biology (01.11.2021)
Published in Nature chemical biology (01.11.2021)
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Journal Article
Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
Popescu, Bogdan, Stahlhut, Carlos, Tarver, Theodore C, Wishner, Sydney, Lee, Bianca J, Peretz, Cheryl A C, Luck, Cuyler, Phojanakong, Paul, Camara Serrano, Juan Antonio, Hongo, Henry, Rivera, Jose M, Xirenayi, Simayijiang, Chukinas, John A, Steri, Veronica, Tasian, Sarah K, Stieglitz, Elliot, Smith, Catherine C
Published in Cell reports. Medicine (21.11.2023)
Published in Cell reports. Medicine (21.11.2023)
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Journal Article
Abstract B108: 4EBP3 mRNA as a biomarker of therapeutic response to treatment with mTORC1 inhibitors
Lee, Bianca J., Dinglasan, Nuntana, Nguyen, Tram, Lorenzana, Ed, Wilson, Stacy, Burnett, G. Leslie, Aggen, James B., Nichols, Robert J., Singh, Mallika, Wildes, David, Smith, Jaqueline A.M.
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Direct targeting of RAS in pancreatic ductal adenocarcinoma with RMC-6236, a first-in-class, RAS-selective, orally bioavailable, tri-complex RAS MULTI (ON) inhibitor
Gustafson, W. Clay, Wildes, David, Rice, Meghan A., Lee, Bianca J., Jiang, Jingjing, Wang, Zhengping, Chang, Stephanie, Flagella, Mike, Mu, Yunming, Dinglasan, Nuntana, Nasholm, Nicole, Evans, James W., Seamon, Kyle, Cregg, Jim, Bermingham, Alun, Freilich, Rebecca, Gill, Adrian L., Koltun, Elena, Smith, Jacqueline A, Singh, Mallika
Published in Journal of clinical oncology (01.02.2022)
Published in Journal of clinical oncology (01.02.2022)
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Journal Article
Abstract 1260: First-in-class, orally bioavailable KRASG12V(ON) tri-complex inhibitors, as single agents and in combinations, drive profound anti-tumor activity in preclinical models of KRASG12V mutant cancers
Koltun, Elena, Cregg, Jim, Rice, Meghan A., Whalen, Dan M., Freilich, Rebecca, Jiang, Jingjing, Hansen, Richard, Bermingham, Alun, Knox, John E., Dinglasan, Jay, Seamon, Kyle, Blaj, Cristina, Chang, Stephanie S., Liu, Yang, Huang, Jun, Chou, Kang-Jye, McDowell, Laura, Lee, Bianca J., Wildes, David, Wang, Zhengping, Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract IA17: Strategies to target the mTORC1/eIF4F axis in B-cell leukemia and lymphoma
Herzog, Lee-or, Lee, Bianca J., Vo, Thanh-Trang, Chiu, Honyin, Mallya, Sharmila, Fung, Amos, Singh, Mallika, Aggen, James, Tibrewal, Nidhi, Smith, Jacqueline A.M., Wildes, David, Ronai, Ze'ev, Ruggero, Davide, Fruman, David A.
Published in Molecular cancer research (01.10.2020)
Published in Molecular cancer research (01.10.2020)
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Journal Article
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth (vol 17, pg 1065, 2021)
Lee, BJ, Boyer, JA, Burnett, GL, Thottumkara, AP, Tibrewal, N, Wilson, SL, Hsieh, T, Marquez, A, Lorenzana, EG, Evans, JW
Published in NATURE CHEMICAL BIOLOGY (01.11.2021)
Published in NATURE CHEMICAL BIOLOGY (01.11.2021)
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Publication
Abstract PR04: 4EBP1 reactivation by potent and selective bi-steric inhibitors of mTORC1
Tibrewal, Nidhi, Aggen, James B., Bassan, Abraham I., Burnett, G. Leslie, Evans, Jim, Gliedt, Micah J., Hsieh, Daphne, Kiss, Gert, Lee, Bianca J., Lee, Dong, Lorenzana, Ed, Marquez, Abby, Thottumkara, Arun, Wang, Zhengping, Wilson, Stacy, Zhao, Frances, Goldsmith, Mark, Singh, Mallika, Wildes, Pete, Gill, Adrian L., Smith, Jacqueline A.M.
Published in Molecular cancer research (01.10.2020)
Published in Molecular cancer research (01.10.2020)
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Journal Article
Abstract B137: Selective inhibition of the active state of KRASG12V with the non-covalent, tri-complex inhibitor RM-048
Lee, Bianca J, Cregg, Jim, Edwards, Anne, Chen, Jerry, Eriksson, Andre, Tonogai, Emily, Tomlinson, Aidan, Seamon, Kyle, Ayala, Mariela Moreno, Shifrin, Nataliya Tovbis, Montazer, Nilufar, Sanders, Kate, Huang, Jun, Chou, Kang-Jye, Madej, Benjamin, Liu, Yang, Wang, Zhican, Wang, Zhengping, Knox, John, Koltun, Elena, Jiang, Jingjing, Gill, Adrian, Smith, Jacqueline A.M.
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract LB015: Bi-steric mTORC1-selective inhibitors activate 4EBP1, suppress MYC, restore anti-tumor immunity, and cooperate with immune checkpoint inhibition to elicit tumor regression
Mahauad-Fernandez, Wadie D., Yang, Yu Chi, Lai, Ian, Park, Jangho, Yao, Lilian, Evans, James W., Atibalentja, Danielle F., Chen, Xinyu, Zhao, Zihui, Burnett, G. Leslie, Lee, Bianca J., Dinglasan, Nuntana, Shifrin, Nataliya, Ahler, Ethan, Quintana, Elsa, Gill, Adrian, Smith, Jacqueline A., Singh, Mallika, Felsher, Dean W.
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Journal Article
Abstract 3597: Direct targeting of KRASG12X mutant cancers with RMC-6236, a first-in-class, RAS-selective, orally bioavailable, tri-complex RASMULTI(ON) inhibitor
Koltun, Elena S., Rice, Meghan A., Gustafson, W. Clay, Wilds, David, Jiang, Jingjing, Lee, Bianca J., Wang, Zhengping, Chang, Stephanie, Flagella, Mike, Mu, Yunming, Dinglasan, Nuntana, Nasholm, Nicole, Evans, James W., Wang, Yingyun, Seamon, Kyle, Liu, Yang, Blaj, Cristina, Knox, John, Freilich, Rebecca, Quintana, Elsa, Cregg, Jim, Bermingham, Alun, Gill, Adrian L., Smith, Jacqueline Am, Singh, Mallika
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Allosteric SHP2 Inhibition Increases Apoptotic Dependency on BCL2 and Synergizes with Venetoclax in FLT3- and KIT- Mutant AML
Popescu, Bogdan, Stahlhut, Carlos, Tarver, Theodore C, Wishner, Sydney, Lee, Bianca J, Peretz, Cheryl A C, Luck, Cuyler, Phojanakong, Paul, Camara Serrano, Juan Antonio, Hongo, Henry, Rivera, Jose M, Xirenayi, Simayijian, Chukinas, John A, Steri, Veronica, Tasian, Sarah K, Stieglitz, Elliot, Smith, Catherine C
Published in bioRxiv (03.12.2022)
Published in bioRxiv (03.12.2022)
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