A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening
Yan, Helen H.N., Siu, Hoi Cheong, Law, Simon, Ho, Siu Lun, Yue, Sarah S.K., Tsui, Wai Yin, Chan, Dessy, Chan, April S., Ma, Stephanie, Lam, Ka On, Bartfeld, Sina, Man, Alice H.Y., Lee, Bernard C.H., Chan, Annie S.Y., Wong, Jason W.H., Cheng, Priscilla S.W., Chan, Anthony K.W., Zhang, Jiangwen, Shi, Jue, Fan, Xiaodan, Kwong, Dora L.W., Mak, Tak W., Yuen, Siu Tsan, Clevers, Hans, Leung, Suet Yi
Published in Cell stem cell (06.12.2018)
Published in Cell stem cell (06.12.2018)
Get full text
Journal Article
RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation
Yan, Helen H N, Lai, Jeffrey C W, Ho, Siu Lun, Leung, Wai Keung, Law, Wai Lun, Lee, Janet F Y, Chan, Anthony K W, Tsui, Wai Yin, Chan, Annie S Y, Lee, Bernard C H, Yue, Sarah S K, Man, Alice H Y, Clevers, Hans, Yuen, Siu Tsan, Leung, Suet Yi
Published in Gut (01.09.2017)
Published in Gut (01.09.2017)
Get full text
Journal Article
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Robinson, Philip S., Coorens, Tim H. H., Palles, Claire, Mitchell, Emily, Abascal, Federico, Olafsson, Sigurgeir, Lee, Bernard C. H., Lawson, Andrew R. J., Lee-Six, Henry, Moore, Luiza, Sanders, Mathijs A., Hewinson, James, Martin, Lynn, Pinna, Claudia M. A., Galavotti, Sara, Rahbari, Raheleh, Campbell, Peter J., Martincorena, Iñigo, Tomlinson, Ian, Stratton, Michael R.
Published in Nature genetics (01.10.2021)
Published in Nature genetics (01.10.2021)
Get full text
Journal Article
Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles
Yan, Helen H N, Siu, Hoi Cheong, Ho, Siu Lun, Yue, Sarah S K, Gao, Yang, Tsui, Wai Yin, Chan, Dessy, Chan, April S, Wong, Jason W H, Man, Alice H Y, Lee, Bernard C H, Chan, Annie S Y, Chan, Anthony K W, Hui, Ho Sang, Cheung, Arthur K L, Law, Wai Lun, Lo, Oswens S H, Yuen, Siu Tsan, Clevers, Hans, Leung, Suet Yi
Published in Gut (01.12.2020)
Published in Gut (01.12.2020)
Get full text
Journal Article
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Robinson, Philip S., Thomas, Laura E., Abascal, Federico, Jung, Hyunchul, Harvey, Luke M. R., West, Hannah D., Olafsson, Sigurgeir, Lee, Bernard C. H., Coorens, Tim H. H., Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A., Lensing, Stefanie V., Buczacki, Simon J. A., ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J., Martincorena, Iñigo, Sampson, Julian R., Stratton, Michael R.
Published in Nature communications (08.07.2022)
Published in Nature communications (08.07.2022)
Get full text
Journal Article
Mutational landscape of normal epithelial cells in Lynch Syndrome patients
Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.
Published in Nature communications (17.05.2022)
Published in Nature communications (17.05.2022)
Get full text
Journal Article