Continuous Flow Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid–Liquid Extraction and Membrane Separation Technology
Lebl, René, Murray, Trevor, Adamo, Andrea, Cantillo, David, Kappe, C. Oliver
Published in ACS sustainable chemistry & engineering (16.12.2019)
Published in ACS sustainable chemistry & engineering (16.12.2019)
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Journal Article
Catalytic Static Mixer-Enabled Hydrogenation of a Key Fenebrutinib Intermediate: Real-Time Analysis for a Stable and Scalable Process
Lebl, René, Bachmann, Stephan, Tosatti, Paolo, Sedelmeier, Joerg, Püntener, Kurt, Williams, Jason D, Kappe, C. Oliver
Published in Organic process research & development (20.08.2021)
Published in Organic process research & development (20.08.2021)
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Journal Article
Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow
Sagmeister, Peter, Lebl, René, Castillo, Ismael, Rehrl, Jakob, Kruisz, Julia, Sipek, Martin, Horn, Martin, Sacher, Stephan, Cantillo, David, Williams, Jason D., Kappe, C. Oliver
Published in Angewandte Chemie International Edition (06.04.2021)
Published in Angewandte Chemie International Edition (06.04.2021)
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Journal Article
Catalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation
Dolan, Martin A, Basa, Prem N, Zozulia, Oleksii, Lengyel, Zsófia, Lebl, René, Kohn, Eric M, Bhattacharya, Sagar, Korendovych, Ivan V
Published in ACS nano (27.08.2019)
Published in ACS nano (27.08.2019)
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Journal Article
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry
Kelly, Sean M., Lebl, René, Malig, Thomas C., Bass, Thomas M., Kummli, Dominique, Kaldre, Dainis, Orcel, Ugo, Tröndlin, Lars, Linder, David, Sedelmeier, Joerg, Bachmann, Stephan, Han, Chong, Zhang, Haiming, Gosselin, Francis
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
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Journal Article
Control of a complex multistep process for the production of mesalazine
Castillo, Ismael, Rehrl, Jakob, Sagmeister, Peter, Lebl, René, Kruisz, Julia, Celikovic, Selma, Sipek, Martin, Kirschneck, Dirk, Horn, Martin, Sacher, Stephan, Cantillo, David, Williams, Jason D., Khinast, Johannes G., Kappe, C. Oliver
Published in Journal of process control (01.02.2023)
Published in Journal of process control (01.02.2023)
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Journal Article
Automated and continuous synthesis of drug substances
Sacher, Stephan, Castillo, Ismael, Rehrl, Jakob, Sagmeister, Peter, Lebl, René, Kruisz, Julia, Celikovic, Selma, Sipek, Martin, Williams, Jason D., Kirschneck, Dirk, Kappe, C. Oliver, Horn, Martin
Published in Chemical engineering research & design (01.01.2022)
Published in Chemical engineering research & design (01.01.2022)
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Journal Article
Leveraging flow chemistry for the synthesis of trisubstituted isoxazoles
Prieschl, Michael, Sulzer, Niklas, Sedelmeier, Joerg, Kaldre, Dainis, Lebl, René, Püntener, Kurt, Hildbrand, Stefan, Williams, Jason D., Kappe, C. Oliver
Published in Journal of flow chemistry (01.12.2023)
Published in Journal of flow chemistry (01.12.2023)
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Journal Article
Development of customized 3D printed stainless steel reactors with inline oxygen sensors for aerobic oxidation of Grignard reagents in continuous flow
Maier, Manuel C., Lebl, René, Sulzer, Philipp, Lechner, Josef, Mayr, Torsten, Zadravec, Matej, Slama, Eyke, Pfanner, Stefan, Schmölzer, Christoph, Pöchlauer, Peter, Kappe, C. Oliver, Gruber-Woelfler, Heidrun
Published in Reaction chemistry & engineering (01.02.2019)
Published in Reaction chemistry & engineering (01.02.2019)
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Journal Article
Oxygen sensors for flow reactors - measuring dissolved oxygen in organic solvents
Sulzer, Philipp, Lebl, René, Kappe, C. Oliver, Mayr, Torsten
Published in Reaction chemistry & engineering (01.12.2019)
Published in Reaction chemistry & engineering (01.12.2019)
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Journal Article
A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors
Lebl, René, Thonhofer, Martin, Tysoe, Christina, Pabst, Bettina M., Schalli, Michael, Weber, Patrick, Paschke, Eduard, Stütz, Arnold E., Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G.
Published in Carbohydrate research (10.04.2017)
Published in Carbohydrate research (10.04.2017)
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Journal Article
Back Cover: Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow (Angew. Chem. Int. Ed. 15/2021)
Sagmeister, Peter, Lebl, René, Castillo, Ismael, Rehrl, Jakob, Kruisz, Julia, Sipek, Martin, Horn, Martin, Sacher, Stephan, Cantillo, David, Williams, Jason D., Kappe, C. Oliver
Published in Angewandte Chemie International Edition (06.04.2021)
Published in Angewandte Chemie International Edition (06.04.2021)
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Journal Article
Rücktitelbild: Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow (Angew. Chem. 15/2021)
Sagmeister, Peter, Lebl, René, Castillo, Ismael, Rehrl, Jakob, Kruisz, Julia, Sipek, Martin, Horn, Martin, Sacher, Stephan, Cantillo, David, Williams, Jason D., Kappe, C. Oliver
Published in Angewandte Chemie (06.04.2021)
Published in Angewandte Chemie (06.04.2021)
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Journal Article
Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow
Sagmeister, Peter, Lebl, René, Castillo, Ismael, Rehrl, Jakob, Kruisz, Julia, Sipek, Martin, Horn, Martin, Sacher, Stephan, Cantillo, David, Williams, Jason D., Kappe, C. Oliver
Published in Angewandte Chemie (06.04.2021)
Published in Angewandte Chemie (06.04.2021)
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Journal Article
Integration of Bromine and Cyanogen Bromide Generators for the Continuous‐Flow Synthesis of Cyclic Guanidines
Glotz, Gabriel, Lebl, René, Dallinger, Doris, Kappe, C. Oliver
Published in Angewandte Chemie (23.10.2017)
Published in Angewandte Chemie (23.10.2017)
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Journal Article
Rücktitelbild: Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow (Angew. Chem. 15/2021)
Sagmeister, Peter, Lebl, René, Castillo, Ismael, Rehrl, Jakob, Kruisz, Julia, Sipek, Martin, Horn, Martin, Sacher, Stephan, Cantillo, David, Williams, Jason D., Kappe, C. Oliver
Published in Angewandte Chemie (06.04.2021)
Published in Angewandte Chemie (06.04.2021)
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Journal Article