Mechanisms of cardiac ethanol toxicity and novel treatment options
Mustroph, Julian, Lebek, Simon, Maier, Lars S., Neef, Stefan
Published in Pharmacology & therapeutics (Oxford) (01.05.2019)
Published in Pharmacology & therapeutics (Oxford) (01.05.2019)
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Journal Article
A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction
Lebek, Simon, Hegner, Philipp, Schach, Christian, Reuthner, Kathrin, Tafelmeier, Maria, Maier, Lars Siegfried, Arzt, Michael, Wagner, Stefan
Published in PloS one (10.12.2020)
Published in PloS one (10.12.2020)
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Journal Article
Empagliflozin inhibits Na+/H+ exchanger activity in human atrial cardiomyocytes
Trum, Maximilian, Riechel, Johannes, Lebek, Simon, Pabel, Steffen, Sossalla, Samuel T., Hirt, Stephan, Arzt, Michael, Maier, Lars S., Wagner, Stefan
Published in ESC Heart Failure (01.12.2020)
Published in ESC Heart Failure (01.12.2020)
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Journal Article
Empagliflozin reduces Ca/calmodulin‐dependent kinase II activity in isolated ventricular cardiomyocytes
Mustroph, Julian, Wagemann, Olivia, Lücht, Charlotte M., Trum, Maximilian, Hammer, Karin P., Sag, Can Martin, Lebek, Simon, Tarnowski, Daniel, Reinders, Jörg, Perbellini, Filippo, Terracciano, Cesare, Schmid, Christof, Schopka, Simon, Hilker, Michael, Zausig, York, Pabel, Steffen, Sossalla, Samuel T., Schweda, Frank, Maier, Lars S., Wagner, Stefan
Published in ESC Heart Failure (01.08.2018)
Published in ESC Heart Failure (01.08.2018)
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Journal Article
CaMKIIδ-dependent dysregulation of atrial Na+ homeostasis promotes pro-arrhythmic activity in an obstructive sleep apnea mouse model
Hegner, Philipp, Ofner, Florian, Schaner, Benedikt, Gugg, Mathias, Trum, Maximilian, Lauerer, Anna-Maria, Maier, Lars Siegfried, Arzt, Michael, Lebek, Simon, Wagner, Stefan
Published in Frontiers in pharmacology (20.06.2024)
Published in Frontiers in pharmacology (20.06.2024)
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Journal Article
CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea
Hegner, Philipp, Lebek, Simon, Schaner, Benedikt, Ofner, Florian, Gugg, Mathias, Maier, Lars Siegfried, Arzt, Michael, Wagner, Stefan
Published in Antioxidants (29.01.2023)
Published in Antioxidants (29.01.2023)
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Journal Article
Abnormal P‐wave terminal force in lead V1 is a marker for atrial electrical dysfunction but not structural remodelling
Lebek, Simon, Wester, Michael, Pec, Jan, Poschenrieder, Florian, Tafelmeier, Maria, Fisser, Christoph, Provaznik, Zdenek, Schopka, Simon, Debl, Kurt, Schmid, Christof, Buchner, Stefan, Maier, Lars S., Arzt, Michael, Wagner, Stefan
Published in ESC Heart Failure (01.10.2021)
Published in ESC Heart Failure (01.10.2021)
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Journal Article
Female Patients With Sleep-Disordered Breathing Display More Frequently Heart Failure With Preserved Ejection Fraction
Lebek, Simon, Hegner, Philipp, Tafelmeier, Maria, Rupprecht, Leopold, Schmid, Christof, Maier, Lars Siegfried, Arzt, Michael, Wagner, Stefan
Published in Frontiers in medicine (28.05.2021)
Published in Frontiers in medicine (28.05.2021)
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Journal Article
Enhanced Heart Failure in Redox-Dead Cys17Ser PKARIα Knock-In Mice
Islam, M M Towhidul, Tarnowski, Daniel, Zhang, Min, Trum, Maximilian, Lebek, Simon, Mustroph, Julian, Daniel, Henriette, Moellencamp, Johanna, Pabel, Steffen, Sossalla, Samuel, El-Armouche, Ali, Nikolaev, Viacheslav O, Shah, Ajay M, Eaton, Philip, Maier, Lars S, Sag, Can Martin, Wagner, Stefan
Published in Journal of the American Heart Association (05.10.2021)
Published in Journal of the American Heart Association (05.10.2021)
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Journal Article
Sleep-Disordered Breathing Is Associated With Reduced Left Atrial Strain Measured by Cardiac Magnetic Resonance Imaging in Patients After Acute Myocardial Infarction
Wester, Michael, Pec, Jan, Lebek, Simon, Fisser, Christoph, Debl, Kurt, Hamer, Okka, Poschenrieder, Florian, Buchner, Stefan, Maier, Lars S, Arzt, Michael, Wagner, Stefan
Published in Frontiers in medicine (16.02.2022)
Published in Frontiers in medicine (16.02.2022)
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Journal Article
Enhanced CaMKII-Dependent Late I Na Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing
Lebek, Simon, Pichler, Konstantin, Reuthner, Kathrin, Trum, Maximillian, Tafelmeier, Maria, Mustroph, Julian, Camboni, Daniele, Rupprecht, Leopold, Schmid, Christof, Maier, Lars S, Arzt, Michael, Wagner, Stefan
Published in Circulation research (28.02.2020)
Published in Circulation research (28.02.2020)
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Journal Article
Gene editing in common cardiovascular diseases
Lauerer, Anna-Maria, Caravia, Xurde M., Maier, Lars S., Chemello, Francesco, Lebek, Simon
Published in Pharmacology & therapeutics (Oxford) (14.09.2024)
Published in Pharmacology & therapeutics (Oxford) (14.09.2024)
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Journal Article
Systemic inflammation predicts diastolic dysfunction in patients with sleep-disordered breathing
Hegner, Philipp, Wester, Michael, Tafelmeier, Maria, Provaznik, Zdenek, Klatt, Susanne, Schmid, Christof, Maier, Lars Siegfried, Arzt, Michael, Wagner, Stefan, Lebek, Simon
Published in The European respiratory journal (01.06.2024)
Published in The European respiratory journal (01.06.2024)
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Journal Article
Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor
Neef, Stefan, Steffens, Alexander, Pellicena, Patricia, Mustroph, Julian, Lebek, Simon, Ort, Katharina R., Schulman, Howard, Maier, Lars S.
Published in Journal of molecular and cellular cardiology (01.02.2018)
Published in Journal of molecular and cellular cardiology (01.02.2018)
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Journal Article
Sleep-disordered breathing is independently associated with reduced atrial connexin 43 expression
Hegner, Philipp, Lebek, Simon, Tafelmeier, Maria, Camboni, Daniele, Schopka, Simon, Schmid, Christof, Maier, Lars Siegfried, Arzt, Michael, Wagner, Stefan
Published in Heart rhythm (01.12.2021)
Published in Heart rhythm (01.12.2021)
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Journal Article
Ethanol-Induced Atrial Fibrillation Results From Late I Na and Can Be Prevented by Ranolazine
Mustroph, Julian, Baier, Maria J., Unsin, Denise, Provaznik, Zdenek, Kozakov, Kostiantyn, Lebek, Simon, Tarnowski, Daniel, Schildt, Sönke, Voigt, Niels, Wagner, Stefan, Maier, Lars S., Neef, Stefan
Published in Circulation (New York, N.Y.) (22.08.2023)
Published in Circulation (New York, N.Y.) (22.08.2023)
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Journal Article
Voltage-Gated Sodium Channel NaV1.8 Dysregulates Na and Ca, Leading to Arrhythmias in Patients with Sleep-Disordered Breathing
Lebek, Simon, Hegner, Philipp, Hultsch, Rosa, Rohde, Jonas, Rupprecht, Leopold, Schmid, Christof, Sossalla, Samuel, Maier, Lars Siegfried, Arzt, Michael, Wagner, Stefan
Published in American journal of respiratory and critical care medicine (01.12.2022)
Published in American journal of respiratory and critical care medicine (01.12.2022)
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Journal Article
Elimination of CaMKIIδ Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice
Lebek, Simon, Caravia, Xurde M, Chemello, Francesco, Tan, Wei, McAnally, John R, Chen, Kenian, Xu, Lin, Liu, Ning, Bassel-Duby, Rhonda, Olson, Eric N
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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Journal Article