Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide
Milnes, James T, Witchel, Harry J, Leaney, Joanne L, Leishman, Derek J, Hancox, Jules C
Published in Journal of pharmacological and toxicological methods (01.03.2010)
Published in Journal of pharmacological and toxicological methods (01.03.2010)
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Journal Article
Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 °C: Cisapride versus dofetilide
Milnes, James T., Witchel, Harry J., Leaney, Joanne L., Leishman, Derek J., Hancox, Jules C.
Published in Journal of pharmacological and toxicological methods (01.03.2010)
Published in Journal of pharmacological and toxicological methods (01.03.2010)
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Journal Article
hERG K + channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656
Milnes, James T., Witchel, Harry J., Leaney, Joanne L., Leishman, Derek J., Hancox, Jules C.
Published in Biochemical and biophysical research communications (08.12.2006)
Published in Biochemical and biophysical research communications (08.12.2006)
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Journal Article
Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs
Perry, Matthew, Stansfeld, Phillip J, Leaney, Joanne, Wood, Claire, de Groot, Marcel J, Leishman, Derek, Sutcliffe, Michael J, Mitcheson, John S
Published in Molecular pharmacology (01.02.2006)
Published in Molecular pharmacology (01.02.2006)
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Journal Article
Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca2+-independent protein kinase C
Leaney, Joanne L., Dekker, Lodewijk V., Tinker, Andrew
Published in The Journal of physiology (15.07.2001)
Published in The Journal of physiology (15.07.2001)
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Journal Article
PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells
Brown, Sean G, Thomas, Alison, Dekker, Lodewijk V, Tinker, Andrew, Leaney, Joanne L
Published in American Journal of Physiology: Cell Physiology (01.09.2005)
Published in American Journal of Physiology: Cell Physiology (01.09.2005)
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Journal Article
Erythromycin block of the HERG K + channel: Accessibility to F656 and Y652
Duncan, Rona S., Ridley, John M., Dempsey, Christopher E., Leishman, Derek J., Leaney, Joanne L., Hancox, Jules C., Witchel, Harry J.
Published in Biochemical and biophysical research communications (10.03.2006)
Published in Biochemical and biophysical research communications (10.03.2006)
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Journal Article
Differential phosphoinositide binding to components of the G protein-gated K+ channel
Thomas, Alison M, Brown, Sean G, Leaney, Joanne L, Tinker, Andrew
Published in The Journal of membrane biology (01.05.2006)
Published in The Journal of membrane biology (01.05.2006)
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Journal Article
A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits
Leaney, Joanne L, Benians, Amy, Graves, Fiona M, Tinker, Andrew
Published in The Journal of biological chemistry (09.08.2002)
Published in The Journal of biological chemistry (09.08.2002)
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Journal Article
The Role of Members of the Pertussis Toxin-Sensitive Family of G Proteins in Coupling Receptors to the Activation of the G Protein-Gated Inwardly Rectifying Potassium Channel
Leaney, Joanne Louise, Tinker, Andrew
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2000)
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Journal Article
Aztreonam–avibactam versus meropenem for the treatment of serious infections caused by Gram-negative bacteria (REVISIT): a descriptive, multinational, open-label, phase 3, randomised trial
Carmeli, Yehuda, Cisneros, José Miguel, Paul, Mical, Daikos, George L, Wang, Minggui, Torre-Cisneros, Julian, Singer, George, Titov, Ivan, Gumenchuk, Illia, Zhao, Yongjie, Jiménez-Rodríguez, Rosa-María, Liang, Lu, Chen, Gang, Pyptiuk, Oleksandr, Aksoy, Firdevs, Rogers, Halley, Wible, Michele, Arhin, Francis F, Luckey, Alison, Leaney, Joanne L, Pypstra, Rienk, Chow, Joseph W, Bonten, Marc, Rodríguez-Baño, Jesús, Lammens, Christine, Goossens, Herman, Malhotra-Kumar, Surbhi
Published in The Lancet infectious diseases (07.10.2024)
Published in The Lancet infectious diseases (07.10.2024)
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Journal Article
2893 A. Efficacy and Safety of Aztreonam-Avibactam for the Treatment of Serious Infections Due to Gram-Negative Bacteria, Including Metallo-β-Lactamase-Producing Pathogens: Phase 3 REVISIT Study
Carmeli, Yehuda, Cisneros, Jose-Miguel, Paul, Mical, Daikos, Georgios L, Wang, Minggui, Cisneros, Julian Torre, Singer, George, Titov, Ivan, Gumenchuk, Illia, Zhao, Yongjie, Jiménez Rodríguez, Rosa-María, Liang, Lu, Chen, Gang, Pyptiuk, Oleksandr, Aksoy, Firdevs, Rogers, Halley, Wible, Michele, Arhin, Francis, Luckey, Alison, Leaney, Joanne, Pypstra, Rienk, Chow, Joseph
Published in Open forum infectious diseases (27.11.2023)
Published in Open forum infectious diseases (27.11.2023)
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Journal Article
The Molecular Assembly of ATP-sensitive Potassium Channels
Giblin, Jonathan P., Leaney, Joanne L., Tinker, Andrew
Published in The Journal of biological chemistry (06.08.1999)
Published in The Journal of biological chemistry (06.08.1999)
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Journal Article
The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues
Alexandrou, A J, Milnes, J T, Sun, S Z, Fermini, B, Kim, S C, Jenkinson, S, Leishman, D J, Witchel, H J, Hancox, J C, Leaney, J L
Published in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society (01.08.2014)
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Published in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society (01.08.2014)
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