Deep Neural Networks Can Predict New-Onset Atrial Fibrillation From the 12-Lead ECG and Help Identify Those at Risk of Atrial Fibrillation-Related Stroke
Raghunath, Sushravya, Pfeifer, John M, Ulloa-Cerna, Alvaro E, Nemani, Arun, Carbonati, Tanner, Jing, Linyuan, vanMaanen, David P, Hartzel, Dustin N, Ruhl, Jeffery A, Lagerman, Braxton F, Rocha, Daniel B, Stoudt, Nathan J, Schneider, Gargi, Johnson, Kipp W, Zimmerman, Noah, Leader, Joseph B, Kirchner, H Lester, Griessenauer, Christoph J, Hafez, Ashraf, Good, Christopher W, Fornwalt, Brandon K, Haggerty, Christopher M
Published in Circulation (New York, N.Y.) (30.03.2021)
Published in Circulation (New York, N.Y.) (30.03.2021)
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Routinely reported ejection fraction and mortality in clinical practice: where does the nadir of risk lie?
Wehner, Gregory J, Jing, Linyuan, Haggerty, Christopher M, Suever, Jonathan D, Leader, Joseph B, Hartzel, Dustin N, Kirchner, H Lester, Manus, Joseph N A, James, Nick, Ayar, Zina, Gladding, Patrick, Good, Christopher W, Cleland, John G F, Fornwalt, Brandon K
Published in European heart journal (21.03.2020)
Published in European heart journal (21.03.2020)
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Prediction of mortality from 12-lead electrocardiogram voltage data using a deep neural network
Raghunath, Sushravya, Ulloa Cerna, Alvaro E., Jing, Linyuan, vanMaanen, David P., Stough, Joshua, Hartzel, Dustin N., Leader, Joseph B., Kirchner, H. Lester, Stumpe, Martin C., Hafez, Ashraf, Nemani, Arun, Carbonati, Tanner, Johnson, Kipp W., Young, Katelyn, Good, Christopher W., Pfeifer, John M., Patel, Aalpen A., Delisle, Brian P., Alsaid, Amro, Beer, Dominik, Haggerty, Christopher M., Fornwalt, Brandon K.
Published in Nature medicine (01.06.2020)
Published in Nature medicine (01.06.2020)
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Patient-Centered Precision Health In A Learning Health Care System: Geisinger's Genomic Medicine Experience
Williams, Marc S, Buchanan, Adam H, Davis, F Daniel, Faucett, W Andrew, Hallquist, Miranda L G, Leader, Joseph B, Martin, Christa L, McCormick, Cara Z, Meyer, Michelle N, Murray, Michael F, Rahm, Alanna K, Schwartz, Marci L B, Sturm, Amy C, Wagner, Jennifer K, Williams, Janet L, Willard, Huntington F, Ledbetter, David H
Published in Health Affairs (01.05.2018)
Published in Health Affairs (01.05.2018)
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Electronic health record analysis identifies kidney disease as the leading risk factor for hospitalization in confirmed COVID-19 patients
Oetjens, Matthew T, Luo, Jonathan Z, Chang, Alexander, Leader, Joseph B, Hartzel, Dustin N, Moore, Bryn S, Strande, Natasha T, Kirchner, H Lester, Ledbetter, David H, Justice, Anne E, Carey, David J, Mirshahi, Tooraj
Published in PloS one (12.11.2020)
Published in PloS one (12.11.2020)
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A Machine Learning Approach to Management of Heart Failure Populations
Jing, Linyuan, Ulloa Cerna, Alvaro E., Good, Christopher W., Sauers, Nathan M., Schneider, Gargi, Hartzel, Dustin N., Leader, Joseph B., Kirchner, H. Lester, Hu, Yirui, Riviello, David M., Stough, Joshua V., Gazes, Seth, Haggerty, Allyson, Raghunath, Sushravya, Carry, Brendan J., Haggerty, Christopher M., Fornwalt, Brandon K.
Published in JACC. Heart failure (01.07.2020)
Published in JACC. Heart failure (01.07.2020)
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Journal Article
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Dewey, Frederick E, Gusarova, Viktoria, Dunbar, Richard L, O’Dushlaine, Colm, Schurmann, Claudia, Gottesman, Omri, McCarthy, Shane, Van Hout, Cristopher V, Bruse, Shannon, Dansky, Hayes M, Leader, Joseph B, Murray, Michael F, Ritchie, Marylyn D, Kirchner, H. Lester, Habegger, Lukas, Lopez, Alex, Penn, John, Zhao, An, Shao, Weiping, Stahl, Neil, Murphy, Andrew J, Hamon, Sara, Bouzelmat, Aurelie, Zhang, Rick, Shumel, Brad, Pordy, Robert, Gipe, Daniel, Herman, Gary A, Sheu, Wayne H.H, Lee, I-Te, Liang, Kae-Woei, Guo, Xiuqing, Rotter, Jerome I, Chen, Yii-Der I, Kraus, William E, Shah, Svati H, Damrauer, Scott, Small, Aeron, Rader, Daniel J, Wulff, Anders Berg, Nordestgaard, Børge G, Tybjærg-Hansen, Anne, van den Hoek, Anita M, Princen, Hans M.G, Ledbetter, David H, Carey, David J, Overton, John D, Reid, Jeffrey G, Sasiela, William J, Banerjee, Poulabi, Shuldiner, Alan R, Borecki, Ingrid B, Teslovich, Tanya M, Yancopoulos, George D, Mellis, Scott J, Gromada, Jesper, Baras, Aris
Published in The New England journal of medicine (20.07.2017)
Published in The New England journal of medicine (20.07.2017)
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Journal Article
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
Dewey, Frederick E, Gusarova, Viktoria, O’Dushlaine, Colm, Gottesman, Omri, Trejos, Jesus, Hunt, Charleen, Van Hout, Cristopher V, Habegger, Lukas, Buckler, David, Lai, Ka-Man V, Leader, Joseph B, Murray, Michael F, Ritchie, Marylyn D, Kirchner, H. Lester, Ledbetter, David H, Penn, John, Lopez, Alexander, Borecki, Ingrid B, Overton, John D, Reid, Jeffrey G, Carey, David J, Murphy, Andrew J, Yancopoulos, George D, Baras, Aris, Gromada, Jesper, Shuldiner, Alan R
Published in The New England journal of medicine (24.03.2016)
Published in The New England journal of medicine (24.03.2016)
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rECHOmmend: An ECG-Based Machine Learning Approach for Identifying Patients at Increased Risk of Undiagnosed Structural Heart Disease Detectable by Echocardiography
Ulloa-Cerna, Alvaro E., Jing, Linyuan, Pfeifer, John M., Raghunath, Sushravya, Ruhl, Jeffrey A., Rocha, Daniel B., Leader, Joseph B., Zimmerman, Noah, Lee, Greg, Steinhubl, Steven R., Good, Christopher W., Haggerty, Christopher M., Fornwalt, Brandon K., Chen, Ruijun
Published in Circulation (New York, N.Y.) (05.07.2022)
Published in Circulation (New York, N.Y.) (05.07.2022)
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Clinical and Molecular Prevalence of Lipodystrophy in an Unascertained Large Clinical Care Cohort
Gonzaga-Jauregui, Claudia, Ge, Wenzhen, Staples, Jeffrey, Van Hout, Cristopher, Yadav, Ashish, Colonie, Ryan, Leader, Joseph B, Kirchner, H Lester, Murray, Michael F, Reid, Jeffrey G, Carey, David J, Overton, John D, Shuldiner, Alan R, Gottesman, Omri, Gao, Steve, Gromada, Jesper, Baras, Aris, Altarejos, Judith
Published in Diabetes (New York, N.Y.) (01.02.2020)
Published in Diabetes (New York, N.Y.) (01.02.2020)
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Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
Kosmicki, Jack A., Horowitz, Julie E., Banerjee, Nilanjana, Lanche, Rouel, Marcketta, Anthony, Maxwell, Evan, Bai, Xiaodong, Sun, Dylan, Backman, Joshua D., Sharma, Deepika, Kury, Fabricio S.P., Kang, Hyun M., O’Dushlaine, Colm, Yadav, Ashish, Mansfield, Adam J., Li, Alexander H., Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Locke, Adam E., Khalid, Shareef, O’Keeffe, Sean, Mbatchou, Joelle, Chazara, Olympe, Huang, Yunfeng, Kvikstad, Erika, O’Neill, Amanda, Nioi, Paul, Parker, Meg M., Petrovski, Slavé, Runz, Heiko, Szustakowski, Joseph D., Wang, Quanli, Wong, Emily, Cordova-Palomera, Aldo, Smith, Erin N., Szalma, Sandor, Zheng, Xiuwen, Esmaeeli, Sahar, Davis, Justin W., Lai, Yi-Pin, Chen, Xing, Justice, Anne E., Leader, Joseph B., Mirshahi, Tooraj, Carey, David J., Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Rader, Daniel J., Povysil, Gundula, Goldstein, David B., Kiryluk, Krzysztof, Pairo-Castineira, Erola, Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Meynert, Alison, Kousathanas, Athanasios, Moutsianas, Loukas, Tenesa, Albert, Caulfield, Mark, Scott, Richard, Wilson, James F., Baillie, J. Kenneth, Butler-Laporte, Guillaume, Nakanishi, Tomoko, Lathrop, Mark, Richards, J. Brent, Jones, Marcus, Balasubramanian, Suganthi, Salerno, William, Shuldiner, Alan R., Marchini, Jonathan, Overton, John D., Habegger, Lukas, Cantor, Michael N., Reid, Jeffrey G., Baras, Aris, Abecasis, Goncalo R., Ferreira, Manuel A.R.
Published in American journal of human genetics (01.07.2021)
Published in American journal of human genetics (01.07.2021)
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Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
Gusarova, Viktoria, O’Dushlaine, Colm, Teslovich, Tanya M., Benotti, Peter N., Mirshahi, Tooraj, Gottesman, Omri, Van Hout, Cristopher V., Murray, Michael F., Mahajan, Anubha, Nielsen, Jonas B., Fritsche, Lars, Wulff, Anders Berg, Gudbjartsson, Daniel F., Sjögren, Marketa, Emdin, Connor A., Scott, Robert A., Lee, Wen-Jane, Small, Aeron, Kwee, Lydia C., Dwivedi, Om Prakash, Prasad, Rashmi B., Bruse, Shannon, Lopez, Alexander E., Penn, John, Marcketta, Anthony, Leader, Joseph B., Still, Christopher D., Kirchner, H. Lester, Mirshahi, Uyenlinh L., Wardeh, Amr H., Hartle, Cassandra M., Habegger, Lukas, Fetterolf, Samantha N., Tusie-Luna, Teresa, Morris, Andrew P., Holm, Hilma, Steinthorsdottir, Valgerdur, Sulem, Patrick, Thorsteinsdottir, Unnur, Rotter, Jerome I., Chuang, Lee-Ming, Damrauer, Scott, Birtwell, David, Brummett, Chad M., Khera, Amit V., Natarajan, Pradeep, Orho-Melander, Marju, Flannick, Jason, Lotta, Luca A., Willer, Cristen J., Holmen, Oddgeir L., Ritchie, Marylyn D., Ledbetter, David H., Murphy, Andrew J., Borecki, Ingrid B., Reid, Jeffrey G., Overton, John D., Hansson, Ola, Groop, Leif, Shah, Svati H., Kraus, William E., Rader, Daniel J., Chen, Yii-Der I., Hveem, Kristian, Wareham, Nicholas J., Kathiresan, Sekar, Melander, Olle, Stefansson, Kari, Nordestgaard, Børge G., Tybjærg-Hansen, Anne, Abecasis, Goncalo R., Altshuler, David, Florez, Jose C., Boehnke, Michael, McCarthy, Mark I., Yancopoulos, George D., Carey, David J., Shuldiner, Alan R., Baras, Aris, Dewey, Frederick E., Gromada, Jesper
Published in Nature communications (13.06.2018)
Published in Nature communications (13.06.2018)
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Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants
Haggerty, Christopher M, Damrauer, Scott M, Levin, Michael G, Birtwell, David, Carey, David J, Golden, Alicia M, Hartzel, Dustin N, Hu, Yirui, Judy, Renae, Kelly, Melissa A, Kember, Rachel L, Lester Kirchner, H, Leader, Joseph B, Liang, Lusha, McDermott-Roe, Chris, Babu, Apoorva, Morley, Michael, Nealy, Zachariah, Person, Thomas N, Pulenthiran, Arichanah, Small, Aeron, Smelser, Diane T, Stahl, Richard C, Sturm, Amy C, Williams, Heather, Baras, Aris, Margulies, Kenneth B, Cappola, Thomas P, Dewey, Frederick E, Verma, Anurag, Zhang, Xinyuang, Correa, Adolfo, Hall, Michael E, Wilson, James G, Ritchie, Marylyn D, Rader, Daniel J, Murray, Michael F, Fornwalt, Brandon K, Arany, Zoltan
Published in Circulation (New York, N.Y.) (02.07.2019)
Published in Circulation (New York, N.Y.) (02.07.2019)
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Profiling and Leveraging Relatedness in a Precision Medicine Cohort of 92,455 Exomes
Staples, Jeffrey, Maxwell, Evan K., Gosalia, Nehal, Gonzaga-Jauregui, Claudia, Snyder, Christopher, Hawes, Alicia, Penn, John, Ulloa, Ricardo, Bai, Xiaodong, Lopez, Alexander E., Van Hout, Cristopher V., O’Dushlaine, Colm, Teslovich, Tanya M., McCarthy, Shane E., Balasubramanian, Suganthi, Kirchner, H. Lester, Leader, Joseph B., Murray, Michael F., Ledbetter, David H., Shuldiner, Alan R., Yancoupolos, George D., Dewey, Frederick E., Carey, David J., Overton, John D., Baras, Aris, Habegger, Lukas, Reid, Jeffrey G.
Published in American journal of human genetics (03.05.2018)
Published in American journal of human genetics (03.05.2018)
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Leveraging population‐based exome screening to impact clinical care: The evolution of variant assessment in the Geisinger MyCode research project
Kelly, Melissa A, Leader, Joseph B, Wain, Karen E, Bodian, Dale, Oetjens, Matthew T, Ledbetter, David H, Martin, Christa L, Strande, Natasha T
Published in American journal of medical genetics. Part C, Seminars in medical genetics (01.03.2021)
Published in American journal of medical genetics. Part C, Seminars in medical genetics (01.03.2021)
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First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring
Helle, Emmi I.T., Biegley, Preston, Knowles, Joshua W., Leader, Joseph B., Pendergrass, Sarah, Yang, Wei, Reaven, Gerald R., Shaw, Gary M., Ritchie, Marylyn, Priest, James R.
Published in The Journal of pediatrics (01.04.2018)
Published in The Journal of pediatrics (01.04.2018)
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Rare coding variants in CHRNB2 reduce the likelihood of smoking
Rajagopal, Veera M., Watanabe, Kyoko, Mbatchou, Joelle, Ayer, Ariane, Quon, Peter, Sharma, Deepika, Kessler, Michael D., Praveen, Kavita, Gelfman, Sahar, Parikshak, Neelroop, Otto, Jacqueline M., Bao, Suying, Chim, Shek Man, Pavlopoulos, Elias, Avbersek, Andreja, Kapoor, Manav, Chen, Esteban, Jones, Marcus B., Leblanc, Michelle, Emberson, Jonathan, Collins, Rory, Torres, Jason, Morales, Pablo Kuri, Tapia-Conyer, Roberto, Alegre, Jesus, Berumen, Jaime, Shuldiner, Alan R., Balasubramanian, Suganthi, Abecasis, Gonçalo R., Kang, Hyun M., Marchini, Jonathan, Stahl, Eli A., Jorgenson, Eric, Sanchez, Robert, Liedtke, Wolfgang, Anderson, Matthew, Cantor, Michael, Lederer, David, Baras, Aris, Coppola, Giovanni
Published in Nature genetics (01.07.2023)
Published in Nature genetics (01.07.2023)
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Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone
Dunn, Michael E., Kithcart, Aaron, Kim, Jee Hae, Ho, Andre Jo-Hao, Franklin, Matthew C., Romero Hernandez, Annabel, de Hoon, Jan, Botermans, Wouter, Meyer, Jonathan, Jin, Ximei, Zhang, Dongqin, Torello, Justin, Jasewicz, Daniel, Kamat, Vishal, Garnova, Elena, Liu, Nina, Rosconi, Michael, Pan, Hao, Karnik, Satyajit, Burczynski, Michael E., Zheng, Wenjun, Rafique, Ashique, Nielsen, Jonas B., De, Tanima, Verweij, Niek, Pandit, Anita, Locke, Adam, Chalasani, Naga, Melander, Olle, Schwantes-An, Tae-Hwi, Baras, Aris, Lotta, Luca A., Musser, Bret J., Mastaitis, Jason, Devalaraja-Narashimha, Kishor B., Rankin, Andrew J., Huang, Tammy, Herman, Gary, Olson, William, Murphy, Andrew J., Yancopoulos, George D., Olenchock, Benjamin A., Morton, Lori
Published in Nature (London) (19.09.2024)
Published in Nature (London) (19.09.2024)
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Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease
Peloso, Gina M, Nomura, Akihiro, Khera, Amit V, Chaffin, Mark, Won, Hong-Hee, Ardissino, Diego, Danesh, John, Schunkert, Heribert, Wilson, James G, Samani, Nilesh, Erdmann, Jeanette, McPherson, Ruth, Watkins, Hugh, Saleheen, Danish, McCarthy, Shane, Teslovich, Tanya M, Leader, Joseph B, Lester Kirchner, H, Marrugat, Jaume, Nohara, Atsushi, Kawashiri, Masa-Aki, Tada, Hayato, Dewey, Frederick E, Carey, David J, Baras, Aris, Kathiresan, Sekar
Published in Circulation. Cardiovascular genetics (01.05.2019)
Published in Circulation. Cardiovascular genetics (01.05.2019)
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Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease
Nomura, Akihiro, Won, Hong-Hee, Khera, Amit V, Takeuchi, Fumihiko, Ito, Kaoru, McCarthy, Shane, Emdin, Connor A, Klarin, Derek, Natarajan, Pradeep, Zekavat, Seyedeh M, Gupta, Namrata, Peloso, Gina M, Borecki, Ingrid B, Teslovich, Tanya M, Asselta, Rosanna, Duga, Stefano, Merlini, Piera A, Correa, Adolfo, Kessler, Thorsten, Wilson, James G, Bown, Matthew J, Hall, Alistair S, Braund, Peter S, Carey, David J, Murray, Michael F, Kirchner, H Lester, Leader, Joseph B, Lavage, Daniel R, Manus, J Neil, Hartze, Dustin N, Samani, Nilesh J, Schunkert, Heribert, Marrugat, Jaume, Elosua, Roberto, McPherson, Ruth, Farrall, Martin, Watkins, Hugh, Juang, Jyh-Ming J, Hsiung, Chao A, Lin, Shih-Yi, Wang, Jun-Sing, Tada, Hayato, Kawashiri, Masa-Aki, Inazu, Akihiro, Yamagishi, Masakazu, Katsuya, Tomohiro, Nakashima, Eitaro, Nakatochi, Masahiro, Yamamoto, Ken, Yokota, Mitsuhiro, Momozawa, Yukihide, Rotter, Jerome I, Lander, Eric S, Rader, Daniel J, Danesh, John, Ardissino, Diego, Gabriel, Stacey, Willer, Cristen J, Abecasis, Goncalo R, Saleheen, Danish, Kubo, Michiaki, Kato, Norihiro, Ida Chen, Yii-Der, Dewey, Frederick E, Kathiresan, Sekar
Published in Circulation research (23.06.2017)
Published in Circulation research (23.06.2017)
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