Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension
Tamura, Yuichi, Phan, Carole, Tu, Ly, Le Hiress, Morane, Thuillet, Raphaël, Jutant, Etienne-Marie, Fadel, Elie, Savale, Laurent, Huertas, Alice, Humbert, Marc, Guignabert, Christophe
Published in The Journal of clinical investigation (01.05.2018)
Published in The Journal of clinical investigation (01.05.2018)
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Journal Article
Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex
Le Hiress, Morane, Tu, Ly, Ricard, Nicolas, Phan, Carole, Thuillet, Raphaël, Fadel, Elie, Dorfmüller, Peter, Montani, David, de Man, Frances, Humbert, Marc, Huertas, Alice, Guignabert, Christophe
Published in American journal of respiratory and critical care medicine (15.10.2015)
Published in American journal of respiratory and critical care medicine (15.10.2015)
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Journal Article
Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension
Guignabert, Christophe, Phan, Carole, Seferian, Andrei, Huertas, Alice, Tu, Ly, Thuillet, Raphaël, Sattler, Caroline, Le Hiress, Morane, Tamura, Yuichi, Jutant, Etienne-Marie, Chaumais, Marie-Camille, Bouchet, Stéphane, Manéglier, Benjamin, Molimard, Mathieu, Rousselot, Philippe, Sitbon, Olivier, Simonneau, Gérald, Montani, David, Humbert, Marc
Published in The Journal of clinical investigation (01.09.2016)
Published in The Journal of clinical investigation (01.09.2016)
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Journal Article
Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension
Ricard, Nicolas, Tu, Ly, Le Hiress, Morane, Huertas, Alice, Phan, Carole, Thuillet, Raphaël, Sattler, Caroline, Fadel, Elie, Seferian, Andrei, Montani, David, Dorfmüller, Peter, Humbert, Marc, Guignabert, Christophe
Published in Circulation (New York, N.Y.) (15.04.2014)
Published in Circulation (New York, N.Y.) (15.04.2014)
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Journal Article
Pathogenesis of pulmonary arterial hypertension: lessons from cancer
Guignabert, Christophe, Tu, Ly, Le Hiress, Morane, Ricard, Nicolas, Sattler, Caroline, Seferian, Andrei, Huertas, Alice, Humbert, Marc, Montani, David
Published in European respiratory review (01.12.2013)
Published in European respiratory review (01.12.2013)
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Journal Article
Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension
Huertas, Alice, Phan, Carole, Bordenave, Jennifer, Tu, Ly, Thuillet, Raphaël, Le Hiress, Morane, Avouac, Jérôme, Tamura, Yuichi, Allanore, Yannick, Jovan, Roland, Sitbon, Olivier, Guignabert, Christophe, Humbert, Marc
Published in Chest (01.06.2016)
Published in Chest (01.06.2016)
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Journal Article
Leptin signalling system as a target for pulmonary arterial hypertension therapy
Huertas, Alice, Tu, Ly, Thuillet, Raphaël, Le Hiress, Morane, Phan, Carole, Ricard, Nicolas, Nadaud, Sophie, Fadel, Elie, Humbert, Marc, Guignabert, Christophe
Published in The European respiratory journal (01.04.2015)
Published in The European respiratory journal (01.04.2015)
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Journal Article
Design, Synthesis, and Biological Activity of New ITNIT-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension
Le Hiress, Morane, Akagah, Bernardin, Bernadat, Guillaume, Tu, Ly, Thuillett, Raphael, Huertas, Alice, Phan, Carole, Fadel, Elie, Simonneau, Gerald, Humbert, Marc, Jalce, Gael, Guignabert, Christophe
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Journal Article
Design, Synthesis, and Biological Activity of New N‑(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension
Le Hiress, Morane, Akagah, Bernardin, Bernadat, Guillaume, Tu, Ly, Thuillet, Raphaël, Huertas, Alice, Phan, Carole, Fadel, Elie, Simonneau, Gérald, Humbert, Marc, Jalce, Gaël, Guignabert, Christophe
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Journal Article
Abstract 12186: Therapeutic Effects of Blockade of IL-6/gp130 Signaling in Pulmonary Arterial Hypertension
Tamura, Yuichi, Phan, Carole, Tu, Ly, Thuillet, Raphaël, Le Hiress, Morane, Huertas, Alice, Fadel, Elie, Simonneau, Gerald, Humbert, Marc, Guignabert, Christophe
Published in Circulation (New York, N.Y.) (10.11.2015)
Published in Circulation (New York, N.Y.) (10.11.2015)
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Journal Article
Abstract 12206: Endothelial-derived Mif Contributes to Pulmonary Endothelial Cell Proliferation in Human Pulmonary Arterial Hypertension
Le Hiress, Morane, Tu, Ly, Phan, Carole, Thuillet, Raphaël, Ricard, Nicolas, Seferian, Andrei, Jutant, Etienne-Marie, Fadel, Elie, Simonneau, Gerald, Huertas, Alice, Tamura, Yuichi, Humbert, Marc, Guignabert, Christophe
Published in Circulation (New York, N.Y.) (10.11.2015)
Published in Circulation (New York, N.Y.) (10.11.2015)
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Journal Article
Towards new targets for the treatment of pulmonary arterial hypertension : Importance of cell-cell communications
Tu, Ly, Ghigna, Maria-Rosa, Phan, Carole, Bordenave, Jennifer, Le Hiress, Morane, Thuillet, Raphaël, Ricard, Nicolas, Huertas, Alice, Humbert, Marc, Guignabert, Christophe
Published in Biologie aujourd'hui (2016)
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Published in Biologie aujourd'hui (2016)
Journal Article
MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
Guignabert, Christophe, Jalce, Gaël, Le Hiress, Morane, Akagah, Bernardin, Tu, Ly
Year of Publication 11.09.2018
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Year of Publication 11.09.2018
Patent
MIF INHIBITORS FOR THE ACUTE OR CHRONIC TREATMENT OF PULMONARY HYPERTENSION
JALCE, Gaël, TU, Ly, LE HIRESS, Morane, GUIGNABERT, Christophe, AKAGAH, Bernardin
Year of Publication 20.01.2021
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Year of Publication 20.01.2021
Patent
MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
JALCE, Gaël, TU, Ly, LE HIRESS, Morane, GUIGNABERT, Christophe, AKAGAH, Bernardin
Year of Publication 21.03.2018
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Year of Publication 21.03.2018
Patent
MIF INHIBITORS FOR THE ACUTE OR CHRONIC TREATMENT OF PULMONARY HYPERTENSION
GUIGNABERT Christophe, AKAGAH Bernardin, JALCE Gaël, TU Ly, LE HIRESS Morane
Year of Publication 23.03.2017
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Year of Publication 23.03.2017
Patent
MIF INHIBITORS FOR THE ACUTE OR CHRONIC TREATMENT OF PULMONARY HYPERTENSION
JALCE, Gaël, TU, Ly, LE HIRESS, Morane, GUIGNABERT, Christophe, AKAGAH, Bernardin
Year of Publication 22.03.2017
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Year of Publication 22.03.2017
Patent
MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
AKAGAH, BERNARDIN, TU, LY, JALCE, GAËL, GUIGNABERT, CHRISTOPHE, LE HIRESS, MORANE
Year of Publication 09.03.2016
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Year of Publication 09.03.2016
Patent
MIF INHIBITORS FOR THE ACUTE OR CHRONIC TREATMENT OF PULMONARY HYPERTENSION
AKAGAH, BERNARDIN, TU, LY, JALCE, GAËL, GUIGNABERT, CHRISTOPHE, LE HIRESS, MORANE
Year of Publication 19.11.2015
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Year of Publication 19.11.2015
Patent
MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
AKAGAH, BERNARDIN, TU, LY, JALCE, GAËL, GUIGNABERT, CHRISTOPHE, LE HIRESS, MORANE
Year of Publication 18.11.2015
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Year of Publication 18.11.2015
Patent