Establishment of two quantitative nested qPCR assays targeting the human EPO transgene
Neuberger, E W I, Perez, I, Le Guiner, C, Moser, D, Ehlert, T, Allais, M, Moullier, P, Simon, P, Snyder, R O
Published in Gene therapy (01.04.2016)
Published in Gene therapy (01.04.2016)
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Efficient central nervous system AAVrh10-mediated intrathecal gene transfer in adult and neonate rats
Hordeaux, J, Dubreil, L, Deniaud, J, Iacobelli, F, Moreau, S, Ledevin, M, Le Guiner, C, Blouin, V, Le Duff, J, Mendes-Madeira, A, Rolling, F, Cherel, Y, Moullier, P, Colle, M-A
Published in Gene therapy (01.04.2015)
Published in Gene therapy (01.04.2015)
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Exhaustive characterization of the newly developed Duchenne muscular dystrophy rat model: a unique animal model for DMD which mimics the human disease at both the muscular and the cardiac levels
Huchet, C., Toumaniantz, G., Larcher, T., Fraysse, B., Lafoux, A., Remy, S., Caudal, D., Allais, M., Amosse, E., Anegon, I., Guiner, C. Le
Published in Neuromuscular disorders : NMD (01.10.2017)
Published in Neuromuscular disorders : NMD (01.10.2017)
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P.20.11 Dystrophin rescue needed to recover a correct location of nNOS and the return to a normalized RyR1 status in treated GRMD dogs
Gentil, C, le Guiner, C, Cherel, Y, Montus, M, Moulier, P, Servais, L, Voit, T, Pietri-Rouxel, F
Published in Neuromuscular disorders : NMD (01.10.2013)
Published in Neuromuscular disorders : NMD (01.10.2013)
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Adeno-associated virus vector (AAV) microdystrophin gene therapy prolongs survival and restores muscle function in the canine model of Duchenne muscular dystrophy (DMD)
Le Guiner, C, Servais, L, Montus, M, Bodvael, F, Gjata, B, Hogrel, J.Y, Carlier, P, Moullec, S, Masurier, C, Adjali, O, Mingozzi, F, Koo, T, Athanasopoulos, T, Cherel, Y, Mavilio, F, Voit, T, Moullier, P, Dickson, G
Published in Neuromuscular disorders : NMD (2015)
Published in Neuromuscular disorders : NMD (2015)
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The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site
Del Gatto-Konczak, Fabienne, Bourgeois, Cyril F., Le Guiner, Caroline, Kister, Liliane, Gesnel, Marie-Claude, Stévenin, James, Breathnach, Richard
Published in Molecular and Cellular Biology (01.09.2000)
Published in Molecular and Cellular Biology (01.09.2000)
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P.20.13 Gene therapy of Duchenne Muscular Dystrophy using rAAV vectors: Exon skipping and microdystrophin approaches in GRMD dogs
Le Guiner, C, Montus, M, Servais, L, Cherel, Y, Hogrel, J.Y, Carlier, P, Masurier, C, Adjali, O, Mavilio, F, Dickson, G, Moullier, P, Voit, T, Consortium, AFM-Duchenne
Published in Neuromuscular disorders : NMD (01.10.2013)
Published in Neuromuscular disorders : NMD (01.10.2013)
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Journal Article
T.I.3 Perspectives on microdystrophins and delivery
Dickson, G, Le Guiner, C, Montus, M, Servais, L, Cherel, Y, Hogrel, J.Y, Carlier, P, Masurier, C, Adjali, O, Athanasopoulos, T, Koo, T, Malerba, A, Mavilio, F, Voit, T, Moullier, P
Published in Neuromuscular disorders : NMD (01.10.2013)
Published in Neuromuscular disorders : NMD (01.10.2013)
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Journal Article
G.P.92
Servais, L, Le Guiner, C, Montus, M, Cherel, Y, Francois, V, Thibaud, J.L, Wary, C, Matot, B, Larche, T, Guigand, L, Dutilleul, M, Goubin, H, Deschamps, J.Y, Domenger, C, Allais, M, Le Duff, J, Devaux, M, Jaulin, N, Guilbaud, M, Adjali, O, Latournerie, V, Veron, P, Boutin, S, Leborgne, C, Desgue, D, Moullec, S, Barnay-Toutain, F, Riviere, C, Delaunay, N, Bonne, G, Masurier, C, Hogrel, J.Y, Carlier, P, Moullier, P, Voit, T
Published in Neuromuscular disorders : NMD (01.10.2014)
Published in Neuromuscular disorders : NMD (01.10.2014)
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T.P.23 Quantitative evaluation of locoregional high venous pressure rAAV8-U7- ESE6-ESE8 exon-skipping therapy in the GRMD dog using NMR 1H imaging and 31P spectroscopy
Thibaud, J.L., Wary, C., Moullec, S., Azzabou, N., Le Guiner, C., Garcia, L., Montus, M., Cherel, Y., Fromes, Y., Servais, L., Roques, S., Moullier, P., Voit, T., Carlier, P.G.
Published in Neuromuscular disorders : NMD (01.10.2012)
Published in Neuromuscular disorders : NMD (01.10.2012)
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P.20.14 Non ambulant patients with deletion treatable by exon skipping 53 present a more severe phenotype than the general Duchenne population
Servais, L, Seferian, A, Ben Yahou, R, Leturcq, F, Zehrouni, K, Benali, M, Decostre, V, Delahais, V, Butoianu, N, Cuisset, J.M, Cances, C, Le Moing, A.G, Laugel, V, Klein, A, Sabouraud, P, Le Guiner, C, Moullier, P, Moraux, A, Hogrel, J.Y, Montus, M, Voit, T
Published in Neuromuscular disorders : NMD (01.10.2013)
Published in Neuromuscular disorders : NMD (01.10.2013)
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Journal Article
O.4 Forelimb loco-regional injection of rAAV8-U7snRNA in GRMD dogs allows dose-dependant dystrophin expression and phenotypic correction
Servais, L, Le Guiner, C, Montus, M, Garcia, L, Fromes, Y, Hogrel, J.Y, Carlier, P, Cherel, Y, Moullier, P, Voit, T
Published in Neuromuscular disorders : NMD (01.10.2011)
Published in Neuromuscular disorders : NMD (01.10.2011)
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DMD – BIOMARKERS & OUTCOME MEASURES: P.122 Translational implications of increased S100-beta and Tau5 proteins in dystrophic nerves of mdx mouse and rat models for Duchenne muscular dystrophy
Krishnan, V., Thanigaiarasu, L., Overzier, M., Aartsma-Rus, A., Bogdanik, L., Lutz, C., Larcher, T., Guiner, C. Le, Grounds, M.
Published in Neuromuscular disorders : NMD (01.10.2020)
Published in Neuromuscular disorders : NMD (01.10.2020)
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DMD – BIOMARKERS & OUTCOME MEASURES
Krishnan, V., Thanigaiarasu, L., Overzier, M., Aartsma-Rus, A., Bogdanik, L., Lutz, C., Larcher, T., Guiner, C. Le, Grounds, M.
Published in Neuromuscular disorders : NMD (01.10.2020)
Published in Neuromuscular disorders : NMD (01.10.2020)
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Serum Profiling Identifies Novel Muscle miRNA and Cardiomyopathy-Related miRNA Biomarkers in Golden Retriever Muscular Dystrophy Dogs and Duchenne Muscular Dystrophy Patients
Jeanson-Leh, Laurence, Lameth, Julie, Krimi, Soraya, Buisset, Julien, Amor, Fatima, Le Guiner, Caroline, Barthélémy, Inès, Servais, Laurent, Blot, Stéphane, Voit, Thomas, Israeli, David
Published in The American journal of pathology (01.11.2014)
Published in The American journal of pathology (01.11.2014)
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DMD – ANIMAL MODELS: EP.89 TRPC1 and TRPC3 involvement in DMD physiopathology and as potential targets for treatment in complement to rAAV-microdystrophin
Creisméas, A., Gazaille, C., Bourdon, A., Lafoux, A., Allais, M., Razavet, V. Le, Ledevin, M., Larcher, T., Toumanianz, G., Anegon, I., Adjali, O., Huchet, C., Guiner, C. Le, Fraysse, B.
Published in Neuromuscular disorders : NMD (01.10.2021)
Published in Neuromuscular disorders : NMD (01.10.2021)
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DMD – ANIMAL MODELS
Creisméas, A., Gazaille, C., Bourdon, A., Lafoux, A., Allais, M., Razavet, V. Le, Ledevin, M., Larcher, T., Toumanianz, G., Anegon, I., Adjali, O., Huchet, C., Guiner, C. Le, Fraysse, B.
Published in Neuromuscular disorders : NMD (01.10.2021)
Published in Neuromuscular disorders : NMD (01.10.2021)
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NEW THERAPEUTIC APPROACHES AND THEIR READOUT
Dumonceaux, J., Mariot, V., Le Guiner, C., Barthelemy, I., Hourdé, C., Montus, M., Blot, S., Voit, T.
Published in Neuromuscular disorders : NMD (01.10.2018)
Published in Neuromuscular disorders : NMD (01.10.2018)
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NEW THERAPEUTIC APPROACHES AND THEIR READOUT: O.16Myostatin expression is a reliable and quantifiable biomarker to monitor dose-dependent drug response in muscular dystrophy
Dumonceaux, J., Mariot, V., Le Guiner, C., Barthelemy, I., Hourdé, C., Montus, M., Blot, S., Voit, T.
Published in Neuromuscular disorders : NMD (01.10.2018)
Published in Neuromuscular disorders : NMD (01.10.2018)
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