Drugging Undruggable Molecular Cancer Targets
Lazo, John S, Sharlow, Elizabeth R
Published in Annual review of pharmacology and toxicology (06.01.2016)
Published in Annual review of pharmacology and toxicology (06.01.2016)
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Journal Article
microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells
PENG WANG, FANGDONG ZOU, XIAODONG ZHANG, HUA LI, DULAK, Austin, TOMKO, Robert J, LAZO, John S, ZHENGHE WANG, LIN ZHANG, JIAN YU
Published in Cancer research (Chicago, Ill.) (15.10.2009)
Published in Cancer research (Chicago, Ill.) (15.10.2009)
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Journal Article
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z
Gosai, Sager J, Kwak, Joon Hyeok, Luke, Cliff J, Long, Olivia S, King, Dale E, Kovatch, Kevin J, Johnston, Paul A, Shun, Tong Ying, Lazo, John S, Perlmutter, David H, Silverman, Gary A, Pak, Stephen C
Published in PloS one (12.11.2010)
Published in PloS one (12.11.2010)
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Journal Article
Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations
Sharlow, Elizabeth R, Llaneza, Danielle C, Tewari, Bhanu P, Mingledorff, Garnett A, Mendelson, Anna J, Sontheimer, Harald, Bloom, George S, Lazo, John S
Published in The FEBS journal (01.10.2023)
Published in The FEBS journal (01.10.2023)
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Journal Article
The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells
Colunga Biancatelli, Ruben M L, Solopov, Pavel A, Sharlow, Elizabeth R, Lazo, John S, Marik, Paul E, Catravas, John D
Published in American journal of physiology. Lung cellular and molecular physiology (01.08.2021)
Published in American journal of physiology. Lung cellular and molecular physiology (01.08.2021)
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Journal Article
The Substrate Recognition Domains of the N-end Rule Pathway
Tasaki, Takafumi, Zakrzewska, Adriana, Dudgeon, Drew D., Jiang, Yonghua, Lazo, John S., Kwon, Yong Tae
Published in The Journal of biological chemistry (16.01.2009)
Published in The Journal of biological chemistry (16.01.2009)
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Journal Article
Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase
Lazo, John S, Blanco, Isabella K, Tasker, Nikhil R, Rastelli, Ettore J, Burnett, James C, Garrott, Sharon R, Hart, Duncan J, McCloud, Rebecca L, Hsu, Ku-Lung, Wipf, Peter, Sharlow, Elizabeth R
Published in The Journal of pharmacology and experimental therapeutics (01.12.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2019)
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Journal Article
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization
Clausen, Dana M, Guo, Jianxia, Parise, Robert A, Beumer, Jan H, Egorin, Merrill J, Lazo, John S, Prochownik, Edward V, Eiseman, Julie L
Published in The Journal of pharmacology and experimental therapeutics (01.12.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2010)
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Journal Article
Improved low molecular weight Myc-Max inhibitors
Wang, Huabo, Hammoudeh, Dalia I, Follis, Ariele Viacava, Reese, Brian E, Lazo, John S, Metallo, Steven J, Prochownik, Edward V
Published in Molecular cancer therapeutics (01.09.2007)
Published in Molecular cancer therapeutics (01.09.2007)
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Journal Article
Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone
Sharlow, Elizabeth R., Giridhar, Karthik V., LaValle, Courtney R., Chen, Jun, Leimgruber, Stephanie, Barrett, Rebecca, Bravo-Altamirano, Karla, Wipf, Peter, Lazo, John S., Wang, Q. Jane
Published in The Journal of biological chemistry (28.11.2008)
Published in The Journal of biological chemistry (28.11.2008)
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Journal Article
Low molecular weight inhibitors of Myc-Max interaction and function
XIAOYING YIN, GIAP, Christine, LAZO, John S, PROCHOWNIK, Edward V
Published in Oncogene (18.09.2003)
Published in Oncogene (18.09.2003)
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Journal Article
Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities
Vázquez Rivera, Alondra, Donald, Heather, Alaoui-El-Azher, Mounia, Skoko, John J., Lazo, John S., Parniak, Michael A., Johnston, Paul A., Sluis-Cremer, Nicolas
Published in Biomolecules (Basel, Switzerland) (09.07.2024)
Published in Biomolecules (Basel, Switzerland) (09.07.2024)
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Journal Article
Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production
Aguilar-Sopeña, Oscar, Hernández-Pérez, Sara, Alegre-Gómez, Sergio, Castro-Sánchez, Patricia, Iglesias-Ceacero, Alba, Lazo, John S, Roda-Navarro, Pedro
Published in International journal of molecular sciences (05.04.2020)
Published in International journal of molecular sciences (05.04.2020)
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Journal Article
Diallyl trisulfide-induced G2-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C
DONG XIAO, HERMAN-ANTOSIEWICZ, Anna, ANTOSIEWICZ, Jedrzej, HUI XIAO, BRISSON, Marni, LAZO, John S, SINGH, Shivendra V
Published in Oncogene (15.09.2005)
Published in Oncogene (15.09.2005)
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Journal Article
The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1
Vogt, Andreas, Tamewitz, Aletheia, Skoko, John, Sikorski, Rachel P., Giuliano, Kenneth A., Lazo, John S.
Published in The Journal of biological chemistry (13.05.2005)
Published in The Journal of biological chemistry (13.05.2005)
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Journal Article