New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease
Ekimova, Irina V., Plaksina, Daria V., Pastukhov, Yuri F., Lapshina, Ksenia V., Lazarev, Vladimir F., Mikhaylova, Elena R., Polonik, Sergey G., Pani, Bibhusita, Margulis, Boris A., Guzhova, Irina V., Nudler, Evgeny
Published in Experimental neurology (01.08.2018)
Published in Experimental neurology (01.08.2018)
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Journal Article
Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress
Mikeladze, Marina A, Dutysheva, Elizaveta A, Kartsev, Victor G, Margulis, Boris A, Guzhova, Irina V, Lazarev, Vladimir F
Published in International journal of molecular sciences (03.02.2021)
Published in International journal of molecular sciences (03.02.2021)
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Journal Article
Indolylazine Derivative Induces Chaperone Expression in Aged Neural Cells and Prevents the Progression of Alzheimer's Disease
Lazarev, Vladimir F, Dutysheva, Elizaveta A, Mikhaylova, Elena R, Trestsova, Maria A, Utepova, Irina A, Chupakhin, Oleg N, Margulis, Boris A, Guzhova, Irina V
Published in Molecules (Basel, Switzerland) (15.12.2022)
Published in Molecules (Basel, Switzerland) (15.12.2022)
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Journal Article
Protein Interactome of Amyloid-β as a Therapeutic Target
Lazarev, Vladimir F, Dutysheva, Elizaveta A, Kanunikov, Igor E, Guzhova, Irina V, Margulis, Boris A
Published in Pharmaceuticals (Basel, Switzerland) (01.02.2023)
Published in Pharmaceuticals (Basel, Switzerland) (01.02.2023)
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Journal Article
Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex
Sverchinsky, Dmitry V, Alhasan, Bashar A, Mikeladze, Marina A, Lazarev, Vladimir F, Kuznetcova, Liubov S, Morshneva, Alisa V, Nikotina, Alina D, Ziewanah, Amr, Koludarova, Lidia V, Starkova, Tatiana Y, Margulis, Boris A, Guzhova, Irina V
Published in Journal of experimental & clinical cancer research (25.10.2023)
Published in Journal of experimental & clinical cancer research (25.10.2023)
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Journal Article
Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3
Sverchinsky, Dmitry V, Nikotina, Alina D, Komarova, Elena Y, Mikhaylova, Elena R, Aksenov, Nikolay D, Lazarev, Vladimir F, Mitkevich, Vladimir A, Suezov, Roman, Druzhilovskiy, Dmitry S, Poroikov, Vladimir V, Margulis, Boris A, Guzhova, Irina V
Published in International journal of molecular sciences (25.08.2018)
Published in International journal of molecular sciences (25.08.2018)
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Journal Article
Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti‐cancer drugs
Sverchinsky, Dmitry V., Lazarev, Vladimir F., Semenyuk, Pavel I., Mitkevich, Vladimir A., Guzhova, Irina V., Margulis, Boris A.
Published in FEBS letters (01.12.2017)
Published in FEBS letters (01.12.2017)
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Journal Article
GAPDH binders as potential drugs for the therapy of polyglutamine diseases: Design of a new screening assay
Lazarev, Vladimir F., Benken, Konstantin A., Semenyuk, Pavel I., Sarantseva, Svetlana V., Bolshakova, Olga I., Mikhaylova, Elena R., Muronetz, Vladimir I., Guzhova, Irina V., Margulis, Boris A.
Published in FEBS letters (27.02.2015)
Published in FEBS letters (27.02.2015)
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Journal Article
Combination of a Chaperone Synthesis Inducer and an Inhibitor of GAPDH Aggregation for Rehabilitation after Traumatic Brain Injury: A Pilot Study
Dutysheva, Elizaveta A, Mikhaylova, Elena R, Trestsova, Maria A, Andreev, Alexander I, Apushkin, Danila Yu, Utepova, Irina A, Serebrennikova, Polina O, Akhremenko, Eugenia A, Aksenov, Nikolay D, Bon', Elizaveta I, Zimatkin, Sergey M, Chupakhin, Oleg N, Margulis, Boris A, Guzhova, Irina V, Lazarev, Vladimir F
Published in Pharmaceutics (20.12.2022)
Published in Pharmaceutics (20.12.2022)
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Journal Article
Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells
Meshalkina, Darya A, Shevtsov, Maxim A, Dobrodumov, Anatoliy V, Komarova, Elena Y, Voronkina, Irina V, Lazarev, Vladimir F, Margulis, Boris A, Guzhova, Irina V
Published in Oncotarget (19.04.2016)
Published in Oncotarget (19.04.2016)
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Journal Article
Dataset of NMR-spectra pyrrolyl- and indolylazines and evidence of their ability to induce heat shock genes expression in human neurons
Dutysheva, Elizaveta A., Utepova, Irina A., Trestsova, Maria A., Anisimov, Alexander S., Charushin, Valery N., Chupakhin, Oleg N., Margulis, Boris A., Guzhova, Irina V., Lazarev, Vladimir F.
Published in Data in brief (01.12.2021)
Published in Data in brief (01.12.2021)
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Journal Article
Pyrrolylquinoxaline-2-One Derivative as a Potent Therapeutic Factor for Brain Trauma Rehabilitation
Dutysheva, Elizaveta A, Mikeladze, Marina A, Trestsova, Maria A, Aksenov, Nikolay D, Utepova, Irina A, Mikhaylova, Elena R, Suezov, Roman V, Charushin, Valery N, Chupakhin, Oleg N, Guzhova, Irina V, Margulis, Boris A, Lazarev, Vladimir F
Published in Pharmaceutics (30.04.2020)
Published in Pharmaceutics (30.04.2020)
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Journal Article
Properties of substances inhibiting aggregation of oxidized GAPDH: Data on the interaction with the enzyme and the impact on its intracellular content
Lazarev, Vladimir F., Nikotina, Alina D., Semenyuk, Pavel I., Evstafyeva, Diana B., Mikhaylova, Elena R., Muronetz, Vladimir I., Shevtsov, Maxim A., Tolkacheva, Anastasia V., Dobrodumov, Anatoly V., Shavarda, Alexey L., Guzhova, Irina V., Margulis, Boris A.
Published in Data in brief (01.06.2016)
Published in Data in brief (01.06.2016)
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Synthesis and approbation of new neuroprotective chemicals of pyrrolyl- and indolylazine classes in a cell model of Alzheimer's disease
Dutysheva, Elizaveta A., Utepova, Irina A., Trestsova, Maria A., Anisimov, Alexander S., Charushin, Valery N., Chupakhin, Oleg N., Margulis, Boris A., Guzhova, Irina V., Lazarev, Vladimir F.
Published in European journal of medicinal chemistry (15.10.2021)
Published in European journal of medicinal chemistry (15.10.2021)
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Journal Article
Novel mechanism of drug resistance triggered by tumor-associated macrophages through Heat Shock Factor-1 activation
Nikotina, Alina D., Vladimirova, Snezhana A., Kokoreva, Nadezhda E., Nevdakha, Valeria A., Lazarev, Vladimir F., Kuznetcova, Liubov S., Komarova, Elena Y., Suezov, Roman V., Efremov, Sergei, Leonova, Elizaveta, Kartsev, Viktor G., Aksenov, Nikolay D., Margulis, Boris A., Guzhova, Irina V.
Published in Cancer Immunology, Immunotherapy (27.01.2024)
Published in Cancer Immunology, Immunotherapy (27.01.2024)
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Synthesis and biological evaluation of 1,2,4-triazoloazines as potent anticancer agents
Serebrennikova, Polina O, Paznikova, Julia A, Kirnos, Eva A, Utepova, Irina A, Kazakova, Elizaveta D, Lazarev, Vladimir F, Kuznetcova, Liubov S, Margulis, Boris A, Guzhova, Irina V, Chupakhin, Oleg N, Sarapultsev, Alexey P
Published in New journal of chemistry (09.10.2023)
Published in New journal of chemistry (09.10.2023)
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Journal Article
GAPDH-targeted therapy – A new approach for secondary damage after traumatic brain injury on rats
Lazarev, Vladimir F., Dutysheva, Elizaveta A., Komarova, Elena Y., Mikhaylova, Elena R., Guzhova, Irina V., Margulis, Boris A.
Published in Biochemical and biophysical research communications (02.07.2018)
Published in Biochemical and biophysical research communications (02.07.2018)
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