How we manage patients with pyruvate kinase deficiency
Grace, Rachael F., Mark Layton, D., Barcellini, Wilma
Published in British journal of haematology (01.03.2019)
Published in British journal of haematology (01.03.2019)
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Journal Article
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency
Grace, Rachael F, Rose, Christian, Layton, D. Mark, Galactéros, Frédéric, Barcellini, Wilma, Morton, D. Holmes, van Beers, Eduard J, Yaish, Hassan, Ravindranath, Yaddanapudi, Kuo, Kevin H.M, Sheth, Sujit, Kwiatkowski, Janet L, Barbier, Ann J, Bodie, Susan, Silver, Bruce, Hua, Lei, Kung, Charles, Hawkins, Peter, Jouvin, Marie-Hélène, Bowden, Chris, Glader, Bertil
Published in The New England journal of medicine (05.09.2019)
Published in The New England journal of medicine (05.09.2019)
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White matter integrity and processing speed in sickle cell anemia
Stotesbury, Hanne, Kirkham, Fenella J, Kölbel, Melanie, Balfour, Philippa, Clayden, Jonathan D, Sahota, Sati, Sakaria, Simrat, Saunders, Dawn E, Howard, Jo, Kesse-Adu, Rachel, Inusa, Baba, Pelidis, Maria, Chakravorty, Subarna, Rees, David C, Awogbade, Moji, Wilkey, Olu, Layton, Mark, Clark, Christopher A, Kawadler, Jamie M
Published in Neurology (05.06.2018)
Published in Neurology (05.06.2018)
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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
Layton, Mark E., Kern, Jeffrey C., Hartingh, Timothy J., Shipe, William D., Raheem, Izzat, Kandebo, Monika, Hayes, Robert P., Huszar, Sarah, Eddins, Donnie, Ma, Bennett, Fuerst, Joy, Wollenberg, Gordon K., Li, Jing, Fritzen, Jeff, McGaughey, Georgia B., Uslaner, Jason M., Smith, Sean M., Coleman, Paul J., Cox, Christopher D.
Published in Journal of medicinal chemistry (26.01.2023)
Published in Journal of medicinal chemistry (26.01.2023)
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Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients
Telfer, Paul, De la Fuente, Josu, Sohal, Mamta, Brown, Ralph, Eleftheriou, Perla, Roy, Noémi, Piel, Frédéric B, Chakravorty, Subarna, Gardner, Kate, Velangi, Mark, Drasar, Emma, Shah, Farrukh, Porter, John B, Trompeter, Sara, Atoyebi, Wale, Szydlo, Richard, Anie, Kofi A, Ryan, Kate, Sharif, Joseph, Wright, Josh, Astwood, Emma, Nicolle, C Sarah, Webster, Amy, Roberts, David J, Lugthart, Sanne, Kaya, Banu, Awogbade, Moji, Rees, David C, Hollingsworth, Rob, Inusa, Baba, Howard, Jo, Layton, D Mark
Published in Haematologica (Roma) (01.11.2020)
Published in Haematologica (Roma) (01.11.2020)
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Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus
Vardigan, Joshua D, Pall, Parul S, McDevitt, Dillon S, Huang, ChienJung, Clements, Michelle K, Li, Yuxing, Kraus, Richard L, Breslin, Michael J, Bungard, Christopher J, Nemenov, Mikhail I, Klukinov, Mikhail, Burgey, Chritopher S, Layton, Mark E, Stachel, Shawn J, Lange, Henry S, Savitz, Alan T, Santarelli, Vincent P, Henze, Darrell A, Uslaner, Jason M
Published in Pain (Amsterdam) (08.10.2024)
Published in Pain (Amsterdam) (08.10.2024)
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Journal Article
Bone mineral density in adult patients with pyruvate kinase deficiency on long-term mitapivat treatment
Al-Samkari, Hanny, Grace, Rachael F, Glenthøj, Andreas, Andres, Oliver, Barcellini, Wilma, Galacteros, Frédéric, Kuo, Kevin H M, Layton, D Mark, Morado, Marta, Viprakasit, Vip, Tai, Feng, Urbstonaitis, Rolandas, Morales, Jaime, McGee, Bryan, Beers, Eduard J van
Published in Haematologica (Roma) (01.03.2024)
Published in Haematologica (Roma) (01.03.2024)
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Reference and point-of-care testing for G6PD deficiency: Blood disorder interference, contrived specimens, and fingerstick equivalence and precision
Pal, Sampa, Myburgh, Jane, Bansil, Pooja, Hann, Amanda, Robertson, Lynn, Gerth-Guyette, Emily, Ambler, Gwen, Bizilj, Greg, Kahn, Maria, Zobrist, Stephanie, Manis, Michelle R, Styke, Nickolas A, Allan, Vajra, Ansbro, Richard, Akingbade, Tobi, Bryan, Andrew, Murphy, Sean C, Kublin, James G, Layton, Mark, Domingo, Gonzalo J
Published in PloS one (20.09.2021)
Published in PloS one (20.09.2021)
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Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic
Shurtleff, Valerie W., Layton, Mark E., Parish, Craig A., Perkins, James J., Schreier, John D., Wang, Yunyi, Adam, Gregory C., Alvarez, Nadine, Bahmanjah, Soheila, Bahnck-Teets, Carolyn M., Boyce, Christopher W., Burlein, Christine, Cabalu, Tamara D., Campbell, Brian T., Carroll, Steven S., Chang, Wonsuk, de Lera Ruiz, Manuel, Dolgov, Enriko, Fay, John F., Fox, Nicholas G., Goh, Shih Lin, Hartingh, Timothy J., Hurzy, Danielle M., Kelly, Michael J., Klein, Daniel J., Klingler, Franca-Maria, Krishnamurthy, Harini, Kudalkar, Shalley, Mayhood, Todd W., McKenna, Philip M., Murray, Edward M., Nahas, Debbie, Nawrat, Christopher C., Park, Steven, Qian, Dongming, Roecker, Anthony J., Sharma, Vijeta, Shipe, William D., Su, Jing, Taggart, Robert V., Truong, Quang, Wu, Yin, Zhou, Xiaoyan, Zhuang, Ningning, Perlin, David S., Olsen, David B., Howe, John A., McCauley, John A.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice
Roecker, Anthony J., Egbertson, Melissa, Jones, Kristen L.G., Gomez, Robert, Kraus, Richard L., Li, Yuxing, Koser, Amy Jo, Urban, Mark O., Klein, Rebecca, Clements, Michelle, Panigel, Jacqueline, Daley, Christopher, Wang, Jixin, Finger, Eleftheria N., Majercak, John, Santarelli, Vincent, Gregan, Irene, Cato, Matthew, Filzen, Tracey, Jovanovska, Aneta, Wang, Ying-Hong, Wang, Deping, Joyce, Leo A., Sherer, Edward C., Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Coleman, Paul J., Houghton, Andrea K., Layton, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis
Adissu, Wondimagegn, Brito, Marcelo, Garbin, Eduardo, Macedo, Marcela, Monteiro, Wuelton, Mukherjee, Sandip Kumar, Myburg, Jane, Alam, Mohammad Shafiul, Bancone, Germana, Bansil, Pooja, Pal, Sampa, Sharma, Abhijit, Zobrist, Stephanie, Bryan, Andrew, Chu, Cindy S, Das, Santasabuj, Domingo, Gonzalo J, Hann, Amanda, Kublin, James, Lacerda, Marcus V G, Layton, Mark, Ley, Benedikt, Murphy, Sean C, Nosten, Francois, Pereira, Dhélio, Price, Ric N, Talukdar, Arunansu, Yilma, Daniel, Gerth-Guyette, Emily
Published in PLoS neglected tropical diseases (01.10.2023)
Published in PLoS neglected tropical diseases (01.10.2023)
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The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design
Grace, Rachael F, van Beers, Eduard J, Vives Corrons, Joan-Lluis, Glader, Bertil, Glenthøj, Andreas, Kanno, Hitoshi, Kuo, Kevin H M, Lander, Carl, Layton, D Mark, Pospíŝilová, Dagmar, Viprakasit, Vip, Li, Junlong, Yan, Yan, Boscoe, Audra N, Bowden, Chris, Bianchi, Paola
Published in BMJ open (23.03.2023)
Published in BMJ open (23.03.2023)
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Journal Article
Individual Watershed Areas in Sickle Cell Anemia: An Arterial Spin Labeling Study
Stotesbury, Hanne, Hales, Patrick W, Hood, Anna M, Koelbel, Melanie, Kawadler, Jamie M, Saunders, Dawn E, Sahota, Sati, Rees, David C, Wilkey, Olu, Layton, Mark, Pelidis, Maria, Inusa, Baba P D, Howard, Jo, Chakravorty, Subarna, Clark, Chris A, Kirkham, Fenella J
Published in Frontiers in physiology (03.05.2022)
Published in Frontiers in physiology (03.05.2022)
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Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model
Pero, Joseph E., Rossi, Michael A., Lehman, Hannah D.G.F., Kelly, Michael J., Mulhearn, James J., Wolkenberg, Scott E., Cato, Matthew J., Clements, Michelle K., Daley, Christopher J., Filzen, Tracey, Finger, Eleftheria N., Gregan, Yun, Henze, Darrell A., Jovanovska, Aneta, Klein, Rebecca, Kraus, Richard L., Li, Yuxing, Liang, Annie, Majercak, John M., Panigel, Jacqueline, Urban, Mark O., Wang, Jixin, Wang, Ying-Hong, Houghton, Andrea K., Layton, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
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Journal Article
Na v 1.7 target modulation and efficacy can be measured in nonhuman primate assays
Kraus, Richard L, Zhao, Fuqiang, Pall, Parul S, Zhou, Dan, Vardigan, Joshua D, Danziger, Andrew, Li, Yuxing, Daley, Christopher, Ballard, Jeanine E, Clements, Michelle K, Klein, Rebecca M, Holahan, Marie A, Greshock, Thomas J, Kim, Ronald M, Layton, Mark E, Burgey, Christopher S, Serra, Jordi, Henze, Darrell A, Houghton, Andrea K
Published in Science translational medicine (19.05.2021)
Published in Science translational medicine (19.05.2021)
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Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve
Klein, Rebecca M., Layton, Mark E., Regan, Hillary, Regan, Christopher P., Li, Yuxing, Filzen, Tracey, Cato, Matt, Clements, Michelle K., Wang, Jixin, Sanoja, Raul, Greshock, Thomas J., Roecker, Anthony J., Pero, Joseph E., Kim, Ron, Burgey, Christopher, John, Christopher T., Wang, Ying-Hong, Bhandari, Neetesh, Struyk, Arie, Kraus, Richard L., Henze, Darrell A., Houghton, Andrea K.
Published in Channels (Austin, Tex.) (31.12.2022)
Published in Channels (Austin, Tex.) (31.12.2022)
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