Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration
Trompouki, Eirini, Bowman, Teresa V., Lawton, Lee N., Fan, Zi Peng, Wu, Dai-Chen, DiBiase, Anthony, Martin, Corey S., Cech, Jennifer N., Sessa, Anna K., Leblanc, Jocelyn L., Li, Pulin, Durand, Ellen M., Mosimann, Christian, Heffner, Garrett C., Daley, George Q., Paulson, Robert F., Young, Richard A., Zon, Leonard I.
Published in Cell (28.10.2011)
Published in Cell (28.10.2011)
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Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage
Lien, Wen-Hui, Guo, Xingyi, Polak, Lisa, Lawton, Lee N., Young, Richard A., Zheng, Deyou, Fuchs, Elaine
Published in Cell stem cell (02.09.2011)
Published in Cell stem cell (02.09.2011)
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Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1)
Kanouni, Toufike, Severin, Christophe, Cho, Robert W, Yuen, Natalie Y.-Y, Xu, Jiangchun, Shi, Lihong, Lai, Chon, Del Rosario, Joselyn R, Stansfield, Ryan K, Lawton, Lee N, Hosfield, David, O’Connell, Shawn, Kreilein, Matt M, Tavares-Greco, Paula, Nie, Zhe, Kaldor, Stephen W, Veal, James M, Stafford, Jeffrey A, Chen, Young K
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia
Sanda, Takaomi, Lawton, Lee N., Barrasa, M. Inmaculada, Fan, Zi Peng, Kohlhammer, Holger, Gutierrez, Alejandro, Ma, Wenxue, Tatarek, Jessica, Ahn, Yebin, Kelliher, Michelle A., Jamieson, Catriona H.M., Staudt, Louis M., Young, Richard A., Look, A. Thomas
Published in Cancer cell (14.08.2012)
Published in Cancer cell (14.08.2012)
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ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
Wang, Lu, Tan, Tze King, Durbin, Adam D., Zimmerman, Mark W., Abraham, Brian J., Tan, Shi Hao, Ngoc, Phuong Cao Thi, Weichert-Leahey, Nina, Akahane, Koshi, Lawton, Lee N., Rokita, Jo Lynne, Maris, John M., Young, Richard A., Look, A. Thomas, Sanda, Takaomi
Published in Nature communications (09.12.2019)
Published in Nature communications (09.12.2019)
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Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis
Novershtern, Noa, Subramanian, Aravind, Lawton, Lee N., Mak, Raymond H., Haining, W. Nicholas, McConkey, Marie E., Habib, Naomi, Yosef, Nir, Chang, Cindy Y., Shay, Tal, Frampton, Garrett M., Drake, Adam C.B., Leskov, Ilya, Nilsson, Bjorn, Preffer, Fred, Dombkowski, David, Evans, John W., Liefeld, Ted, Smutko, John S., Chen, Jianzhu, Friedman, Nir, Young, Richard A., Golub, Todd R., Regev, Aviv, Ebert, Benjamin L.
Published in Cell (21.01.2011)
Published in Cell (21.01.2011)
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CXCR4 upregulation is an indicator of sensitivity to B-cell receptor/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas
Chen, Linfeng, Ouyang, Jing, Wienand, Kirsty, Bojarczuk, Kamil, Hao, Yansheng, Chapuy, Bjoern, Neuberg, Donna, Juszczynski, Przemyslaw, Lawton, Lee N, Rodig, Scott J, Monti, Stefano, Shipp, Margaret A
Published in Haematologica (Roma) (01.05.2020)
Published in Haematologica (Roma) (01.05.2020)
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Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
Guenther, Matthew G, Lawton, Lee N, Rozovskaia, Tatiana, Frampton, Garrett M, Levine, Stuart S, Volkert, Thomas L, Croce, Carlo M, Nakamura, Tatsuya, Canaani, Eli, Young, Richard A
Published in Genes & development (15.12.2008)
Published in Genes & development (15.12.2008)
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Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion
Wienand, Kirsty, Chapuy, Bjoern, Stewart, Chip, Dunford, Andrew J., Wu, David, Kim, Jaegil, Kamburov, Atanas, Wood, Timothy R., Cader, Fathima Zumla, Ducar, Matthew D., Thorner, Aaron R., Nag, Anwesha, Heubeck, Alexander T., Buonopane, Michael J., Redd, Robert A., Bojarczuk, Kamil, Lawton, Lee N., Armand, Philippe, Rodig, Scott J., Fromm, Jonathan R., Getz, Gad, Shipp, Margaret A.
Published in Blood advances (10.12.2019)
Published in Blood advances (10.12.2019)
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A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth
Meacham, Corbin E, Lawton, Lee N, Soto-Feliciano, Yadira M, Pritchard, Justin R, Joughin, Brian A, Ehrenberger, Tobias, Fenouille, Nina, Zuber, Johannes, Williams, Richard T, Young, Richard A, Hemann, Michael T
Published in Genes & development (01.03.2015)
Published in Genes & development (01.03.2015)
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DTX3L E3 ligase targets p53 for degradation at poly ADP-ribose polymerase-associated DNA damage sites
Yan, Qingsheng, Ding, Jingyi, Khan, Sumbul Jawed, Lawton, Lee N., Shipp, Margaret A.
Published in iScience (21.04.2023)
Published in iScience (21.04.2023)
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Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL
Bojarczuk, Kamil, Wienand, Kirsty, Ryan, Jeremy A., Chen, Linfeng, Villalobos-Ortiz, Mariana, Mandato, Elisa, Stachura, Joanna, Letai, Anthony, Lawton, Lee N., Chapuy, Bjoern, Shipp, Margaret A.
Published in Blood (03.01.2019)
Published in Blood (03.01.2019)
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A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma
Cader, Fathima Zumla, Hu, Xihao, Goh, Walter L., Wienand, Kirsty, Ouyang, Jing, Mandato, Elisa, Redd, Robert, Lawton, Lee N., Chen, Pei-Hsuan, Weirather, Jason L., Schackmann, Ron C. J., Li, Bo, Ma, Wenjiang, Armand, Philippe, Rodig, Scott J., Neuberg, Donna, Liu, X. Shirley, Shipp, Margaret A.
Published in Nature medicine (01.09.2020)
Published in Nature medicine (01.09.2020)
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ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis
Leong, Wei Zhong, Tan, Shi Hao, Ngoc, Phuong Cao Thi, Amanda, Stella, Yam, Alice Wei Yee, Liau, Wei-Siang, Gong, Zhiyuan, Lawton, Lee N, Tenen, Daniel G, Sanda, Takaomi
Published in Genes & development (01.12.2017)
Published in Genes & development (01.12.2017)
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The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia
Mansour, Marc R, Sanda, Takaomi, Lawton, Lee N, Li, Xiaoyu, Kreslavsky, Taras, Novina, Carl D, Brand, Marjorie, Gutierrez, Alejandro, Kelliher, Michelle A, Jamieson, Catriona H M, von Boehmer, Harald, Young, Richard A, Look, A Thomas
Published in The Journal of experimental medicine (29.07.2013)
Published in The Journal of experimental medicine (29.07.2013)
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Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta
Lawton, Lee N, Bonaldo, Maria de Fatima, Jelenc, Pierre C, Qiu, Ling, Baumes, Susan A, Marcelino, Rudy A, de Jesus, Gracielle M, Wellington, Sandra, Knowles, James A, Warburton, Dorothy, Brown, Stephen, Soares, Marcelo Bento
Published in Gene (05.12.1997)
Published in Gene (05.12.1997)
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The role of the chromatin remodeler Mi-2β in hematopoietic stem cell self-renewal and multilineage differentiation
Yoshida, Toshimi, Hazan, Idit, Zhang, Jiangwen, Ng, Samuel Y., Naito, Taku, Snippert, Hugo J., Heller, Elizabeth J., Qi, Xiaoqing, Lawton, Lee N., Williams, Christine J., Georgopoulos, Katia
Published in Genes & development (01.05.2008)
Published in Genes & development (01.05.2008)
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Abstract 2007: Transcriptional regulatory program controlled by the oncogenic transcription factor LMO1 in neuroblastoma
Sanda, Takaomi, Akahanse, Koshi, Abraham, Brian J., Weichert, Nina, Durbin, Adam, Anders, Lars, Tan, Shi Hao, Yam, Alice Wei Yee, Lawton, Lee N., Young, Richard A., Maris, John M., Look, A Thomas
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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MYD88 L265P Augments Proximal B-Cell Receptor Signaling in Large B-Cell Lymphomas Via an Interaction with DOCK8
Mandato, Elisa, Yan, Qingsheng, Ouyang, Jing, Paczkowska, Julia, Qin, Yan, Hao, Yansheng, Bojarczuk, Kamil, Hansen, Julia, Lawton, Lee N., Shipp, Margaret A.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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DTX3L E3 ligase targets p53 for degradation at poly ADP-ribose polymerase-associated DNA damage sites
Yan, Qingsheng, Ding, Jingyi, Khan, Sumbul Jawed, Lawton, Lee N., Shipp, Margaret A.
Published in iScience (19.07.2024)
Published in iScience (19.07.2024)
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