Somatic mutation landscapes at single-molecule resolution
Abascal, Federico, Harvey, Luke M R, Mitchell, Emily, Lawson, Andrew R J, Lensing, Stefanie V, Ellis, Peter, Russell, Andrew J C, Alcantara, Raul E, Baez-Ortega, Adrian, Wang, Yichen, Kwa, Eugene Jing, Lee-Six, Henry, Cagan, Alex, Coorens, Tim H H, Chapman, Michael Spencer, Olafsson, Sigurgeir, Leonard, Steven, Jones, David, Machado, Heather E, Davies, Megan, Øbro, Nina F, Mahubani, Krishnaa T, Allinson, Kieren, Gerstung, Moritz, Saeb-Parsy, Kourosh, Kent, David G, Laurenti, Elisa, Stratton, Michael R, Rahbari, Raheleh, Campbell, Peter J, Osborne, Robert J, Martincorena, Iñigo
Published in Nature (London) (20.05.2021)
Published in Nature (London) (20.05.2021)
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Journal Article
Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas
Forshew, Tim, Tatevossian, Ruth G, Lawson, Andrew RJ, Ma, Jing, Neale, Geoff, Ogunkolade, Babatunji W, Jones, Tania A, Aarum, Johan, Dalton, James, Bailey, Simon, Chaplin, Tracy, Carter, Rowena L, Gajjar, Amar, Broniscer, Alberto, Young, Bryan D, Ellison, David W, Sheer, Denise
Published in The Journal of pathology (01.06.2009)
Published in The Journal of pathology (01.06.2009)
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Journal Article
Extensive heterogeneity in somatic mutation and selection in the human bladder
Lawson, Andrew R J, Abascal, Federico, Coorens, Tim H H, Hooks, Yvette, O'Neill, Laura, Latimer, Calli, Raine, Keiran, Sanders, Mathijs A, Warren, Anne Y, Mahbubani, Krishnaa T A, Bareham, Bethany, Butler, Timothy M, Harvey, Luke M R, Cagan, Alex, Menzies, Andrew, Moore, Luiza, Colquhoun, Alexandra J, Turner, William, Thomas, Benjamin, Gnanapragasam, Vincent, Williams, Nicholas, Rassl, Doris M, Vöhringer, Harald, Zumalave, Sonia, Nangalia, Jyoti, Tubío, José M C, Gerstung, Moritz, Saeb-Parsy, Kourosh, Stratton, Michael R, Campbell, Peter J, Mitchell, Thomas J, Martincorena, Iñigo
Published in Science (American Association for the Advancement of Science) (02.10.2020)
Published in Science (American Association for the Advancement of Science) (02.10.2020)
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Journal Article
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Robinson, Philip S, Coorens, Tim H H, Palles, Claire, Mitchell, Emily, Abascal, Federico, Olafsson, Sigurgeir, Lee, Bernard C H, Lawson, Andrew R J, Lee-Six, Henry, Moore, Luiza, Sanders, Mathijs A, Hewinson, James, Martin, Lynn, Pinna, Claudia M A, Galavotti, Sara, Rahbari, Raheleh, Campbell, Peter J, Martincorena, Iñigo, Tomlinson, Ian, Stratton, Michael R
Published in Nature genetics (01.10.2021)
Published in Nature genetics (01.10.2021)
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Journal Article
Somatic mutant clones colonize the human esophagus with age
Martincorena, Iñigo, Fowler, Joanna C, Wabik, Agnieszka, Lawson, Andrew R J, Abascal, Federico, Hall, Michael W J, Cagan, Alex, Murai, Kasumi, Mahbubani, Krishnaa, Stratton, Michael R, Fitzgerald, Rebecca C, Handford, Penny A, Campbell, Peter J, Saeb-Parsy, Kourosh, Jones, Philip H
Published in Science (American Association for the Advancement of Science) (23.11.2018)
Published in Science (American Association for the Advancement of Science) (23.11.2018)
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Journal Article
Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA
Gale, Davina, Lawson, Andrew R J, Howarth, Karen, Madi, Mikidache, Durham, Bradley, Smalley, Sarah, Calaway, John, Blais, Shannon, Jones, Greg, Clark, James, Dimitrov, Peter, Pugh, Michelle, Woodhouse, Samuel, Epstein, Michael, Fernandez-Gonzalez, Ana, Whale, Alexandra S, Huggett, Jim F, Foy, Carole A, Jones, Gerwyn M, Raveh-Amit, Hadas, Schmitt, Karin, Devonshire, Alison, Green, Emma, Forshew, Tim, Plagnol, Vincent, Rosenfeld, Nitzan
Published in PloS one (16.03.2018)
Published in PloS one (16.03.2018)
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Journal Article
Patterns of within-host genetic diversity in SARS-CoV-2
Tonkin-Hill, Gerry, Martincorena, Inigo, Amato, Roberto, Lawson, Andrew R J, Gerstung, Moritz, Johnston, Ian, Jackson, David K, Park, Naomi, Lensing, Stefanie V, Quail, Michael A, Gonçalves, Sónia, Ariani, Cristina, Spencer Chapman, Michael, Hamilton, William L, Meredith, Luke W, Hall, Grant, Jahun, Aminu S, Chaudhry, Yasmin, Hosmillo, Myra, Pinckert, Malte L, Georgana, Iliana, Yakovleva, Anna, Caller, Laura G, Caddy, Sarah L, Feltwell, Theresa, Khokhar, Fahad A, Houldcroft, Charlotte J, Curran, Martin D, Parmar, Surendra, Alderton, Alex, Nelson, Rachel, Harrison, Ewan M, Sillitoe, John, Bentley, Stephen D, Barrett, Jeffrey C, Torok, M Estee, Goodfellow, Ian G, Langford, Cordelia, Kwiatkowski, Dominic
Published in eLife (13.08.2021)
Published in eLife (13.08.2021)
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Journal Article
Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing
Ellis, Peter, Moore, Luiza, Sanders, Mathijs A, Butler, Timothy M, Brunner, Simon F, Lee-Six, Henry, Osborne, Robert, Farr, Ben, Coorens, Tim H H, Lawson, Andrew R J, Cagan, Alex, Stratton, Mike R, Martincorena, Inigo, Campbell, Peter J
Published in Nature protocols (01.02.2021)
Published in Nature protocols (01.02.2021)
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Journal Article
Author Correction: Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing
Ellis, Peter, Moore, Luiza, Sanders, Mathijs A, Butler, Timothy M, Brunner, Simon F, Lee-Six, Henry, Osborne, Robert, Farr, Ben, Coorens, Tim H H, Lawson, Andrew R J, Cagan, Alex, Stratton, Mike R, Martincorena, Inigo, Campbell, Peter J
Published in Nature protocols (01.06.2023)
Published in Nature protocols (01.06.2023)
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Journal Article
Biodiversity of cytochrome P450 redox systems
McLean, K J, Sabri, M, Marshall, K R, Lawson, R J, Lewis, D G, Clift, D, Balding, P R, Dunford, A J, Warman, A J, McVey, J P, Quinn, A-M, Sutcliffe, M J, Scrutton, N S, Munro, A W
Published in Biochemical Society transactions (01.08.2005)
Published in Biochemical Society transactions (01.08.2005)
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Journal Article
Cardiovascular consequences of life-long exposure to dietary isoflavones in the rat
Douglas, G., Armitage, J. A., Taylor, P. D., Lawson, J. R., Mann, G. E., Poston, L.
Published in The Journal of physiology (01.03.2006)
Published in The Journal of physiology (01.03.2006)
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Journal Article
RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort
Lawson, Andrew R. J., Tatevossian, Ruth G., Phipps, Kim P., Picker, Simon R., Michalski, Antony, Sheer, Denise, Jacques, Thomas S., Forshew, Tim
Published in Acta neuropathologica (01.08.2010)
Published in Acta neuropathologica (01.08.2010)
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Journal Article
RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology
Lawson, Andrew R J, Hindley, Guy F L, Forshew, Tim, Tatevossian, Ruth G, Jamie, Gabriel A, Kelly, Gavin P, Neale, Geoffrey A, Ma, Jing, Jones, Tania A, Ellison, David W, Sheer, Denise
Published in Genome research (01.04.2011)
Published in Genome research (01.04.2011)
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Journal Article
Somatic mutation rates scale with lifespan across mammals
Cagan, Alex, Baez-Ortega, Adrian, Brzozowska, Natalia, Abascal, Federico, Coorens, Tim H H, Sanders, Mathijs A, Lawson, Andrew R J, Harvey, Luke M R, Bhosle, Shriram, Jones, David, Alcantara, Raul E, Butler, Timothy M, Hooks, Yvette, Roberts, Kirsty, Anderson, Elizabeth, Lunn, Sharna, Flach, Edmund, Spiro, Simon, Januszczak, Inez, Wrigglesworth, Ethan, Jenkins, Hannah, Dallas, Tilly, Masters, Nic, Perkins, Matthew W, Deaville, Robert, Druce, Megan, Bogeska, Ruzhica, Milsom, Michael D, Neumann, Björn, Gorman, Frank, Constantino-Casas, Fernando, Peachey, Laura, Bochynska, Diana, Smith, Ewan St John, Gerstung, Moritz, Campbell, Peter J, Murchison, Elizabeth P, Stratton, Michael R, Martincorena, Iñigo
Published in Nature (London) (21.04.2022)
Published in Nature (London) (21.04.2022)
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Journal Article
Extensive phylogenies of human development inferred from somatic mutations
Coorens, Tim H H, Moore, Luiza, Robinson, Philip S, Sanghvi, Rashesh, Christopher, Joseph, Hewinson, James, Przybilla, Moritz J, Lawson, Andrew R J, Spencer Chapman, Michael, Cagan, Alex, Oliver, Thomas R W, Neville, Matthew D C, Hooks, Yvette, Noorani, Ayesha, Mitchell, Thomas J, Fitzgerald, Rebecca C, Campbell, Peter J, Martincorena, Iñigo, Rahbari, Raheleh, Stratton, Michael R
Published in Nature (London) (16.09.2021)
Published in Nature (London) (16.09.2021)
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Journal Article
Business continuity in blood services: two case studies from events with potentially catastrophic effect on the national provision of blood components
Morgan, S. J., Rackham, R. A., Penny, S., Lawson, J. R., Walsh, R. J., Ismay, S. L.
Published in Vox sanguinis (01.02.2015)
Published in Vox sanguinis (01.02.2015)
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Journal Article
Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer
Li, Ruoyan, Ferdinand, John R., Loudon, Kevin W., Bowyer, Georgina S., Laidlaw, Sean, Muyas, Francesc, Mamanova, Lira, Neves, Joana B., Bolt, Liam, Fasouli, Eirini S., Lawson, Andrew R.J., Young, Matthew D., Hooks, Yvette, Oliver, Thomas R.W., Butler, Timothy M., Armitage, James N., Aho, Tev, Riddick, Antony C.P., Gnanapragasam, Vincent, Welsh, Sarah J., Meyer, Kerstin B., Warren, Anne Y., Tran, Maxine G.B., Stewart, Grant D., Cortés-Ciriano, Isidro, Behjati, Sam, Clatworthy, Menna R., Campbell, Peter J., Teichmann, Sarah A., Mitchell, Thomas J.
Published in Cancer cell (12.12.2022)
Published in Cancer cell (12.12.2022)
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Journal Article
The human placenta exhibits a unique transcriptomic void
Gong, Sungsam, Gaccioli, Francesca, Aye, Irving L.M.H., Avellino, Giulia, Cook, Emma, Lawson, Andrew R.J., Harvey, Luke M.R., Smith, Gordon C.S., Charnock-Jones, D. Stephen
Published in Cell reports (Cambridge) (25.07.2023)
Published in Cell reports (Cambridge) (25.07.2023)
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Journal Article
Expression and Characterization of the Two Flavodoxin Proteins of Bacillus subtilis, YkuN and YkuP: Biophysical Properties and Interactions with Cytochrome P450 BioI
Lawson, Rachel J, von Wachenfeldt, Claes, Haq, Ihtshamul, Perkins, John, Munro, Andrew W
Published in Biochemistry (Easton) (05.10.2004)
Published in Biochemistry (Easton) (05.10.2004)
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