Preclinical Characterization of ( R )-3-((3 S ,4 S )-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N -Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
Bristow, Linda J, Gulia, Jyoti, Weed, Michael R, Srikumar, Bettadapura N, Li, Yu-Wen, Graef, John D, Naidu, Pattipati S, Sanmathi, Charulatha, Aher, Jayant, Bastia, Tanmaya, Paschapur, Mahesh, Kalidindi, Narasimharaju, Kumar, Kuchibhotla Vijaya, Molski, Thaddeus, Pieschl, Rick, Fernandes, Alda, Brown, Jeffrey M, Sivarao, Digavalli V, Newberry, Kimberly, Bookbinder, Mark, Polino, Joseph, Keavy, Deborah, Newton, Amy, Shields, Eric, Simmermacher, Jean, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Kallem, Raja Reddy, Sinha, Meenakshee, Ramarao, Manjunath, Vikramadithyan, Reeba K, Thangathirupathy, Srinivasan, Warrier, Jayakumar, Islam, Imadul, Bronson, Joanne J, Olson, Richard E, Macor, John E, Albright, Charlie F, King, Dalton, Thompson, Lorin A, Marcin, Lawrence R, Sinz, Michael
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor
Gillman, Kevin W, Starrett, John E, Parker, Michael F, Xie, Kai, Bronson, Joanne J, Marcin, Lawrence R, McElhone, Kate E, Bergstrom, Carl P, Mate, Robert A, Williams, Richard, Meredith, Jere E, Burton, Catherine R, Barten, Donna M, Toyn, Jeremy H, Roberts, Susan B, Lentz, Kimberley A, Houston, John G, Zaczek, Robert, Albright, Charles F, Decicco, Carl P, Macor, John E, Olson, Richard E
Published in ACS medicinal chemistry letters (10.06.2010)
Published in ACS medicinal chemistry letters (10.06.2010)
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Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481
Boy, Kenneth M, Guernon, Jason M, Zuev, Dmitry S, Xu, Li, Zhang, Yunhui, Shi, Jianliang, Marcin, Lawrence R, Higgins, Mendi A, Wu, Yong-Jin, Krishnananthan, Subramaniam, Li, Jianqing, Trehan, Ashok, Smith, Daniel, Toyn, Jeremy H, Meredith, Jere E, Burton, Catherine R, Kimura, S. Roy, Zvyaga, Tatyana, Zhuo, Xiaoliang, Lentz, Kimberley A, Grace, James E, Denton, Rex, Morrison, John S, Mathur, Arvind, Albright, Charles F, Ahlijanian, Michael K, Olson, Richard E, Thompson, Lorin A, Macor, John E
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder
Marcin, Lawrence R, Warrier, Jayakumar, Thangathirupathy, Srinivasan, Shi, Jianliang, Karageorge, George N, Pearce, Bradley C, Ng, Alicia, Park, Hyunsoo, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Reddy, Aliphedi B, Nagaraju, G, Tonukunuru, Gopikishan, Gupta, Grandhi V. R. K. M, Kamble, Manjunatha, Mannoori, Raju, Cheruku, Srinivas, Jogi, Srinivas, Gulia, Jyoti, Bastia, Tanmaya, Sanmathi, Charulatha, Aher, Jayant, Kallem, Rajareddy, Srikumar, Bettadapura N, Vijaya, Kumar Kuchibhotla, Naidu, Pattipati S, Paschapur, Mahesh, Kalidindi, Narasimharaju, Vikramadithyan, Reeba, Ramarao, Manjunath, Denton, Rex, Molski, Thaddeus, Shields, Eric, Subramanian, Murali, Zhuo, Xiaoliang, Nophsker, Michelle, Simmermacher, Jean, Sinz, Michael, Albright, Charlie, Bristow, Linda J, Islam, Imadul, Bronson, Joanne J, Olson, Richard E, King, Dalton, Thompson, Lorin A, Macor, John E
Published in ACS medicinal chemistry letters (10.05.2018)
Published in ACS medicinal chemistry letters (10.05.2018)
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Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia
Higgins, Mendi A., Marcin, Lawrence R., Christopher Zusi, F., Gentles, Robert, Ding, Min, Pearce, Bradley C., Easton, Amy, Kostich, Walter A., Seager, Matthew A., Bourin, Clotilde, Bristow, Linda J., Johnson, Kim A., Miller, Regina, Hogan, John, Whiterock, Valerie, Gulianello, Michael, Ferrante, Meredith, Huang, Yanling, Hendricson, Adam, Alt, Andrew, Macor, John E., Bronson, Joanne J.
Published in Bioorganic & medicinal chemistry (15.01.2017)
Published in Bioorganic & medicinal chemistry (15.01.2017)
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Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1
Marcin, Lawrence R., Higgins, Mendi A., Zusi, F. Christopher, Zhang, Yunhui, Dee, Michael F., Parker, Michael F., Muckelbauer, Jodi K., Camac, Daniel M., Morin, Paul E., Ramamurthy, Vidhyashankar, Tebben, Andrew J., Lentz, Kimberley A., Grace, James E., Marcinkeviciene, Jovita A., Kopcho, Lisa M., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Meredith, Jere E., Albright, Charles F., Bronson, Joanne J., Macor, John E., Thompson, Lorin A.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780
Toyn, Jeremy H., Thompson, Lorin A., Lentz, Kimberley A., Meredith, Jere E., Burton, Catherine R., Sankaranararyanan, Sethu, Guss, Valerie, Hall, Tracey, Iben, Lawrence G., Krause, Carol M., Krause, Rudy, Lin, Xu-Alan, Pierdomenico, Maria, Polson, Craig, Robertson, Alan S., Denton, R. Rex, Grace, James E., Morrison, John, Raybon, Joseph, Zhuo, Xiaoliang, Snow, Kimberly, Padmanabha, Ramesh, Agler, Michele, Esposito, Kim, Harden, David, Prack, Margaret, Varma, Sam, Wong, Victoria, Zhu, Yingjie, Zvyaga, Tatyana, Gerritz, Samuel, Marcin, Lawrence R., Higgins, Mendi A., Shi, Jianliang, Wei, Cong, Cantone, Joseph L., Drexler, Dieter M., Macor, John E., Olson, Richard E., Ahlijanian, Michael K., Albright, Charles F.
Published in International journal of alzheimer's disease (2014)
Published in International journal of alzheimer's disease (2014)
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Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles
Marcin, Lawrence R., Mattson, Ronald J., Gao, Qi, Wu, Dedong, Molski, Thaddeus F., Mattson, Gail K., Lodge, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Conformationally Restricted Homotryptamines. 2. Indole Cyclopropylmethylamines as Selective Serotonin Reuptake Inhibitors
Mattson, Ronald J, Catt, John D, Denhart, Derek J, Deskus, Jeffrey A, Ditta, Jonathan L, Higgins, Mendi A, Marcin, Lawrence R, Sloan, Charles P, Beno, Brett R, Gao, Qi, Cunningham, Melissa A, Mattson, Gail K, Molski, Thaddeus F, Taber, Matthew T, Lodge, Nicholas J
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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Total Synthesis of (±)-Batrachotoxinin A
Kurosu, Michio, Marcin, Lawrence R, Grinsteiner, Timothy J, Kishi, Yoshito
Published in Journal of the American Chemical Society (08.07.1998)
Published in Journal of the American Chemical Society (08.07.1998)
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Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor
Dalton King, H., Denhart, Derek J., Deskus, Jeffrey A., Ditta, Jonathan L., Epperson, James R., Higgins, Mendi A., Kung, Joyce E., Marcin, Lawrence R., Sloan, Charles P., Mattson, Gail K., Molski, Thaddeus F., Krause, Rudolph G., Bertekap, Robert L., Lodge, Nicholas J., Mattson, Ronald J., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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First-in-Class Antigen-Specific Extracellular Protein Degrader, BHV-1400 for IgA Nephropathy, Selectively Targets Galactose-Deficient IgA for Rapid and Efficient Endolysosomal Degradation in the Liver: SA-PO730
Lee, Seong, Spliid, Charlotte B., Estrella, Ana, Mcgrath, Kathleen, Yousuf, Hanna, Rossi, Ann Marie, Rasile, Brett, Conroy, Scott, Spiegel, David, Dubowchik, Gene, Pirman, David, Car, Bruce D., Marcin, Lawrence R., Bunin, Anna, Coric, Vlad
Published in Journal of the American Society of Nephrology (01.10.2024)
Published in Journal of the American Society of Nephrology (01.10.2024)
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Microwave-assisted synthesis and chiral HPLC separation of 18F-labeled MaxiPost™. An agent for post-stroke neuroprotection
Dischino, Douglas D., Dulac, Heidi A., Gillman, Kevin W., Keller, Lynn S., Kozlowski, Edward S., Marcin, Lawrence R., Mongillo, James J., Starrett Jr, John E.
Published in Journal of labelled compounds & radiopharmaceuticals (31.10.2003)
Published in Journal of labelled compounds & radiopharmaceuticals (31.10.2003)
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Discovery of S3-Truncated, C‑6 Heteroaryl Substituted Aminothiazine β‑Site APP Cleaving Enzyme‑1 (BACE1) Inhibitors
Wu, Yong-Jin, Guernon, Jason, Shi, Jianliang, Marcin, Lawrence, Higgins, Mendi, Rajamani, Ramkumar, Muckelbauer, Jodi, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H, Ahlijanian, Michael K, Albright, Charles F, Macor, John E, Thompson, Lorin A
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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